Spectral Migration of Fluorescence in Graphene Oxide Aqueous Dispersions: Evidence for Excited-State Proton Transfer

Konkena, Bharathi; Vasudevan, S.

doi:10.1021/jz4024755

Cited by 32 publications

(37 citation statements)

References 29 publications

(72 reference statements)

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“…Published work largely examined the pH effect on PL. A small number of investigations have focused on the UV‐visible light absorption, reporting contradictory results: some suggested significant pH dependence on the absorption while others observing virtually no pH dependence . Our data suggest a consistent blueshift of the absorption maximum with increasing pH (Figure S8), similar to recently reported results .…”

Section: Resultssupporting

confidence: 85%

Linear versus Branched Peptide with Same Amino Acid Sequence for Legumain‐Targeting in Macrophages: Targeting Efficiency and Bioimaging Potential

et al. 2020

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The relative legumain‐targeting efficiency of a Y‐shaped peptide and a linear peptide with the same amino acid sequence was investigated using in vitro experiments and computer simulations. Flow cytometry and fluorescence microscopy of cell types with varying levels of legumain expression (RAW 264.7, 4T1, MCF 10 A, MCF 7 and MDA MB 231) revealed that the linear peptide has a higher legumain binding efficiency in legumain‐active cells compared to the Y‐shaped peptide. Peptide‐protein docking simulations showed that the more stable linear peptide binds at the active site of legumain, whereas the Y‐shaped peptide binds at a different site. The Y‐shaped peptide has its asparaginyl binding site (‐Asn‐) coiled into an α‐helix form, and this reduces access to legumain binding. The linear peptide conjugated to fluorescent carbon dots (CDs) displayed enhanced binding efficiency towards legumain. The peptide‐CDs conjugate nanoparticles are stable under pH, temperature, and medium composition conditions similar to that may be expected in tumor environments, suggesting their high potential as a bioimaging agent.

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Section: Resultssupporting

confidence: 85%

Linear versus Branched Peptide with Same Amino Acid Sequence for Legumain‐Targeting in Macrophages: Targeting Efficiency and Bioimaging Potential

et al. 2020

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“…Particularly, decay associated spectroscopy (DAS) and time-resolved area normalized emission spectroscopy (TRANES) methods, that have been so far applied only to few other systems 22,23,24 , substantially contribute to reveal the nature of the luminescence of SiC NCs. We applied time resolved emission spectroscopy (TRES) going beyond the conventional time-correlated single photon counting 25-28 that represents a collection of measurements using two independent variables: wavelength and the time after excitation.…”

Section: Introductionmentioning

confidence: 99%

Identification of Luminescence Centers in Molecular-Sized Silicon Carbide Nanocrystals

et al. 2015

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Understanding the fluorescence of complex systems such as small nanocrystals with various surface terminations in solution is still a scientific challenge. Here we show that the combination of advanced time-resolved spectroscopy and ab initio simulations, aided by surface engineering, is able to 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 2 identify the luminescence centers of such complex systems. Fluorescent water soluble silicon carbide (SiC) nanocrystals have been previously identified as complex molecular systems of silicon, carbon, oxygen and hydrogen held together by covalent bonds that made the identification of their luminescence centers unambiguous. The aqueous solutions of molecular-sized SiC nanocrystals are exceedingly promising candidates to realize bioinert non-perturbative fluorescent nanoparticles for in vivo bioimaging, thus the identification of their luminescent centers is of immediate interest. Here we present identification of two emission centers of this complex system: surface groups involving carbon -oxygen bonds and a defect consisting of silicon -oxygen bonds which becomes the dominant pathway for radiative decay after total reduction of the surface. The identification of these luminescent centers reconciles previous experimental results on the surface and pH dependent emission of SiC nanocrystals and helps design optimized fluorophores and nanosensors for in vivo bioimaging.

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“…We surmise that the carboxy and amino groups on the CND surfaces are sensitive to pH value and may change subtly in different acid or alkaline conditions, thereby affecting the optical properties of the CNDs. 33 , 39 Understanding the origin of complex fluorescence definitely relies strongly on detailed physicochemical characterizations and the discovery of exact molecular structures.…”

Section: Resultsmentioning

confidence: 99%

Carbogenic nanodots derived from organo-templated zeolites with modulated full-color luminescence

et al. 2016

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Spectral Migration of Fluorescence in Graphene Oxide Aqueous Dispersions: Evidence for Excited-State Proton Transfer

Cited by 32 publications

References 29 publications

Linear versus Branched Peptide with Same Amino Acid Sequence for Legumain‐Targeting in Macrophages: Targeting Efficiency and Bioimaging Potential

Linear versus Branched Peptide with Same Amino Acid Sequence for Legumain‐Targeting in Macrophages: Targeting Efficiency and Bioimaging Potential

Identification of Luminescence Centers in Molecular-Sized Silicon Carbide Nanocrystals

Carbogenic nanodots derived from organo-templated zeolites with modulated full-color luminescence

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