Spectral, magnetic and biological studies of 1,4-dibenzoyl-3-thiosemicarbazide complexes with some first row transition metal ions

Abstract

The ligand 1,4-dibenzoyl-3-thiosemicarbazide (DBtsc) forms complexes [M(DBtsc-H)(SCN)] [M = Mn(II), Co(II) or Zn(II)], [M(DBtsc-H)(SCN)(H 2 O)] [M = Ni(II) or Cu(II)], [M(DBtsc-H)Cl] [M = Co(II), Ni(II), Cu(II) or Zn(II)] and [Mn(DBtsc)Cl 2 ], which have been characterized by elemental analyses, magnetic susceptibility measurements, UV/Vis, IR, 1 H and 13 C NMR and FAB mass spectral data. Room temperature ESR spectra of the Mn(II) and Cu(II) complexes yield <g> values, characteristic of tetrahedral and square planar complexes respectively. DBtsc and its soluble complexes have been screened against several bacteria, fungi and tumour cell lines.

Thiosemicarbazones Synthesized from Acetophenones: Tautomerism, Spectrometric Data, Reactivity and Theoretical Calculations

“…Semicarbazones and thiosemicarbazones can form complexes with metals and several of them have exhibit biological activity (particularly antimicrobial and antitumor activity have been reported) [5] [6] [7]. Additionally, they have been used as corrosion inhibitors of certain alloys [8].…”

Crystal structure of [(E)-({2-[3-(2-{(1E)-[(carbamothioylamino)imino]methyl}phenoxy)propoxy]phenyl}methylidene)amino]thiourea with an unknown solvate

“…For the various biological activities of bis-thiosemicarbazones, see: Singh et al (2001); Offiong & Martelli (1997). For general synthesis and assessment of the pharmaceutical properties of thiosemicarbazone scaffold compounds, see: Greenbaum et al (2004); Finch et al (1999); Wilson et al (1974); Du et al (2002) Marzano et al (2009).…”

A Facile Synthesis of Oxoindenothiazine and Dioxospiro(indene‐2,4′‐thiazine) Derivatives from (Substituted ethylidene)hydrazinecarbothioamides

“…Because of variable bonding modes, biological implications, and structural diversity of thiosemicarbazones [14][15][16], they have been used as drugs and are reported to possess a wide variety of biological activities against bacteria, fungi, and certain types of tumor [17,18]. It has been reported that the presence of bulky groups at N4 of the thiosemicarbazone moiety greatly enhances biological activity [19].…”