Spectral-Domain Optical Coherence Tomography Is More Sensitive for Hydroxychloroquine-Related Structural Abnormalities Than Short-Wavelength and Near-Infrared Autofluorescence

Jauregui, Ruben; Parmann, Rait; Nuzbrokh, Yan; Tsang, Stephen H.; Sparrow, Janet R.

doi:10.1167/tvst.9.9.8

Cited by 5 publications

(8 citation statements)

References 34 publications

(55 reference statements)

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“…Jauregui et al similarly reported in a study of 30 patients that SD-OCT was more sensitive in detecting HCQ retinopathy compared with SW-AF and near-infrared autofluorescence (NIR-AF) [58]. They described 10 patients who presented with early changes in the outer retinal layers (EZ attenuation and/or IZ continuity loss) in SD-OCT scans, yet with qualitatively normal SW-AF and NIR-AF scans [58]. Conversely, four patients presented with bull's-eye maculopathy in SW-AF and NIR-AF scans with corresponding parafoveal outer retina disruption on SD-OCT scans [58].…”

Section: Comparison Of Oct and Fafmentioning

confidence: 99%

“…They described 10 patients who presented with early changes in the outer retinal layers (EZ attenuation and/or IZ continuity loss) in SD-OCT scans, yet with qualitatively normal SW-AF and NIR-AF scans [58]. Conversely, four patients presented with bull's-eye maculopathy in SW-AF and NIR-AF scans with corresponding parafoveal outer retina disruption on SD-OCT scans [58]. There were no patients with SW-AF or NIR-AF abnormalities who had normal SD-OCT scans [58].…”

Section: Comparison Of Oct and Fafmentioning

confidence: 99%

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Review of Retinal Imaging Modalities for Hydroxychloroquine Retinopathy

et al. 2023

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This review provides an overview of conventional and novel retinal imaging modalities for hydroxychloroquine (HCQ) retinopathy. HCQ retinopathy is a form of toxic retinopathy resulting from HCQ use for a variety of autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. Each imaging modality detects a different aspect of HCQ retinopathy and shows a unique complement of structural changes. Conventionally, spectral-domain optical coherence tomography (SD-OCT), which shows loss or attenuation of the outer retina and/or retinal pigment epithelium–Bruch’s membrane complex, and fundus autofluorescence (FAF), which shows parafoveal or pericentral abnormalities, are used to assess HCQ retinopathy. Additionally, several variations of OCT (retinal and choroidal thickness measurements, choroidal vascularity index, widefield OCT, en face imaging, minimum intensity analysis, and artificial intelligence techniques) and FAF techniques (quantitative FAF, near-infrared FAF, fluorescence lifetime imaging ophthalmoscopy, and widefield FAF) have been applied to assess HCQ retinopathy. Other novel retinal imaging techniques that are being studied for early detection of HCQ retinopathy include OCT angiography, multicolour imaging, adaptive optics, and retromode imaging, although further testing is required for validation.

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Section: Comparison Of Oct and Fafmentioning

confidence: 99%

Section: Comparison Of Oct and Fafmentioning

confidence: 99%

Review of Retinal Imaging Modalities for Hydroxychloroquine Retinopathy

et al. 2023

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“…Als mögliche Screening-Verfahren stehen hochauflösende Perimetrie, multifokales ERG (mfERG), OCT, NIA und FAF zur Verfügung. Dabei ist die Diskussion, ob eines dieser Verfahren überlegen ist, offen, da die Studien Patienten mit unterschiedlicher Therapiedauer, ohne und mit Retinopathien, oder Retinopathien unterschiedlicher Stadien einschlossen und nur selten alle Untersuchungstechniken eingesetzt wurden 30 , 31 . Darüber hinaus sind mehrere Einzelfälle beschrieben, die nur in jeweils einem diagnostischen Verfahren Veränderungen zeigen.…”

Section: Klinische Anwendungen Und Einsatzmöglichkeitenunclassified

Nahinfrarot-Autofluoreszenz: klinische Anwendung und diagnostische Relevanz

Kellner¹,

Weinitz²,

Farmand³

et al. 2022

Augenheilkunde up2date

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ZusammenfassungDie Nahinfrarot-Autofluoreszenz (NIA) ist ein nicht-invasives Verfahren zur Untersuchung des retinalen Pigmentepithels (RPE) basierend auf der Darstellung des antioxidativen Schutzfaktors Melanin in den RPE-Zellen. Die NIA verbessert die Früherkennung chorioretinaler Erkrankungen, da bei vielen dieser Erkrankungen mit der NIA Strukturveränderungen des RPE nachweisbar sind, bevor sich in anderen Untersuchungen Krankheitszeichen erkennen lassen.

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“…[204] Prolonged FLIO lifetimes have been noted in a parafoveal distribution corresponding to regions of toxicity. [205] Despite this, HD-OCT has been reported as more sensitive for detecting HCQ-related structural damage than either SW-AF or NIR-AF, [206] and current guidelines still recommend HD-OCT and VF as primary screening modalities.…”

Section: Hydroxychloroquine (Hcq)mentioning

confidence: 99%

Fundus Autofluorescence and Clinical Applications

Pole

Ameri

2021

JOVR

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Fundus autofluorescence (FAF) has allowed in vivo mapping of retinal metabolic derangements and structural changes not possible with conventional color imaging. Incident light is absorbed by molecules in the fundus, which are excited and in turn emit photons of specific wavelengths that are captured and processed by a sensor to create a metabolic map of the fundus. Studies on the growing number of FAF platforms has shown each may be suited to certain clinical scenarios. Scanning laser ophthalmoscopes, fundus cameras, and modifications of these each have benefits and drawbacks that must be considered before and after imaging to properly interpret the images. Emerging clinical evidence has demonstrated the usefulness of FAF in diagnosis and management of an increasing number of chorioretinal conditions, such as agerelated macular degeneration, central serous chorioretinopathy, retinal drug toxicities, and inherited retinal degenerations such as retinitis pigmentosa and Stargardt disease. This article reviews commercial imaging platforms, imaging techniques, and clinical applications of FAF.

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Spectral-Domain Optical Coherence Tomography Is More Sensitive for Hydroxychloroquine-Related Structural Abnormalities Than Short-Wavelength and Near-Infrared Autofluorescence

Abstract: Spectral-domain optical coherence tomography is more sensitive for hydroxychloroquine-related structural abnormalities than short-wavelength and near-infrared autofluorescence.

Cited by 5 publications

References 34 publications

Review of Retinal Imaging Modalities for Hydroxychloroquine Retinopathy

Review of Retinal Imaging Modalities for Hydroxychloroquine Retinopathy

Nahinfrarot-Autofluoreszenz: klinische Anwendung und diagnostische Relevanz

Fundus Autofluorescence and Clinical Applications

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