Spectral-domain optical coherence tomography for early glaucoma assessment: analysis of macular ganglion cell complex versus peripapillary retinal nerve fiber layer

Moreno, Pilar A.; Konno, Bruno; Lima, Verônica Castro; Castro, Dinorah Piacentini Engel; Castro, L. C.; Leite, Mauro T.; Pacheco, M. A.; Lee, Jae Min; Prata, Tiago S.

doi:10.1016/j.jcjo.2011.09.006

Cited by 59 publications

(42 citation statements)

References 30 publications

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“…18 Evidence is accumulating that measurements of the inner retinal layers in the macular region may be additional parameters for glaucoma detection. [4][5][6]19,20 Previous studies have shown that GCC and cpRNFL thickness exhibit similar diagnostic performance for the detection of early glaucoma. 5,21 The first report by Schulze et al using RTVue (mean MD in the glaucomatous eyes ¼À1.76 dB) demonstrated that the AUCs of the average cpRNFL and GCC thickness were 0.828 and 0.789, respectively.…”

Section: Discussionmentioning

confidence: 99%

Comparative Assessment for the Ability of Cirrus, RTVue, and 3D-OCT to Diagnose Glaucoma

Akashi¹,

Kanamori²,

Nakamura³

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. We compared the ability of circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular parameters obtained by three spectral-domain optical coherence tomography (SD-OCT) instruments to detect glaucoma. METHODS.We enrolled 87 normal eyes and 145 glaucomatous eyes (75 early glaucomatous eyes (EGs), mean deviation > À6 dB). Each participant was imaged using Cirrus, RTVue, and 3D-OCT to evaluate the average and quadrant cpRNFL thicknesses. The macular retinal nerve fiber layer (mRNFL), ganglion cell layer plus inner plexiform layer (GCL/IPL), and mRNFL þ GCL/IPL (ganglion cell complex [GCC]) thicknesses were analyzed. The areas under the receiver operating characteristic curves (AUCs) were compared among the instruments.RESULTS. These instruments revealed similar AUCs for the average cpRNFL and GCC thicknesses in EGs, and total all-stage glaucomatous eyes (TGs). RTVue showed better performance in the nasal cpRNFL thickness than Cirrus and 3D-OCT, and better performance in the temporal cpRNFL thickness than 3D-OCT in TGs. RTVue had a higher AUC for the superior GCC thickness compared to Cirrus and 3D-OCT in EGs, and TGs. Cirrus had higher AUCs for GCL/IPL parameters in TGs, and lower AUCs for the mRNFL parameters in EGs and TGs compared to 3D-OCT.CONCLUSIONS. The average cpRNFL and GCC thicknesses measured using these OCT instruments exhibited similar abilities in the diagnosis of glaucoma, and RTVue exhibited better diagnostic abilities than Cirrus and 3D-OCT for nasal cpRNFL, and superior GCC thicknesses. The diagnostic performance of Cirrus and 3D-OCT was different for GCL/IPL and mRNFL parameters.

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Section: Discussionmentioning

confidence: 99%

Comparative Assessment for the Ability of Cirrus, RTVue, and 3D-OCT to Diagnose Glaucoma

Akashi¹,

Kanamori²,

Nakamura³

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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“…In addition, the likely false positive rate of such a diagnostic test (i.e., macular full-thickness analysis) might be high. The measurement of perifoveal GCC thickness has emerged as a new early diagnostic parameter of glaucoma in recent years [14]. It has been reported that glaucoma preferentially affects GCC rather than all macular layers [15].…”

Section: Discussionmentioning

confidence: 99%

Posterior pole asymmetry analysis and retinal thickness measurements in young relatives of glaucoma patients

Pekel

Acer

Yağcı

et al. 2015

The Kaohsiung J of Med Scie

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The presence of a family history of glaucoma is a known risk factor for primary open-angle glaucoma (POAG) in middle-aged and older individuals. In this study, our aim was to demonstrate possible early glaucomatous alterations in young first- and second-degree relatives of POAG patients by spectral-domain optical coherence tomography. A total of 104 participants (52 relatives of POAG patients and 52 healthy individuals) were recruited in this cross-sectional study. All the participants were between 17 years and 45 years of age. All eyes underwent testing with spectral-domain optical coherence tomography. Peripapillary retinal nerve fiber layer thickness, hemifield macular thickness, macular ganglion cell complex thickness, posterior pole asymmetry analysis, and retinal arteriolar caliber measurements were taken for comparison between the study and control groups. The mean peripapillary retinal nerve fiber layer thickness was 104.9 ± 8.8 μm in the study group and 105.6 ± 7.4 μm in the control group (p = 0.68). Although whole macular thickness measurements were higher in the control group when compared with the study group (p = 0.008), the macular ganglion cell complex thickness was similar in both groups (p = 0.87). The posterior pole asymmetry analysis revealed no statistically significant difference between the groups in the aspect of consecutive black squares (p = 0.79). The mean retinal arteriolar caliber was 85.9 ± 4.8 μm in the study group and 86.0 ± 5.0 μm in the control group (p = 0.90). In conclusion, young relatives of POAG patients do not show characteristic glaucomatous damage when compared with the controls.

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“…10 Segmented measurements of the macular region have been suggested as a useful tool for structural assessment of glaucomatous patients. [11][12][13] For example, Rao and colleagues have compared RNFL and macular thickness measurements for glaucoma detection. They included 140 eyes of 106 glaucoma patients and 74 eyes of 40 healthy subjects and showed that both parameters have a good ability to detect eyes with glaucomatous VF loss with sensitivities at 80% specificity of 80.0% for RNFL thickness and 80.7% for ganglion cell complex (GCC), respectively.…”

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confidence: 99%

“…The sensitivities at 80% specificity for average GCC and pRNFL thickness were 66.7% (cutoff, 89.9 mm) and 62.9% (cutoff, 111.8 mm), respectively. 11 The RTVue-100 (Optovue Inc., Fremont, CA), one of the commercially available SDOCT devices, has a scan rate of 26,000 A-scans per second and an axial resolution of 5 mm. 14,15 The high scanning speed of the RTVue enables the acquisition of a greater number of scans in a single imaging session compared with time-domain OCT, reducing the need for data interpolation and motion artifacts.…”

mentioning

confidence: 99%

“…[16][17][18] For example, one can cite a greater prevalence of focal neuroretinal rim loss and central VF involvement in LTG eyes. [16][17][18] Although previous studies from our group and from others research have shown that both the RNFL and macular GCC scans have reasonable ability to detect eyes with glaucoma as reported before, 11,14 the comparison of such protocols in eyes with HTG and LTG has not yet been established.…”

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confidence: 99%

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Identification of the Most Accurate Spectral-domain Optical Coherence Tomography Parameters in Eyes With Early High-Tension and Low-Tension Glaucoma

Gracitelli

Moreno

Leite

et al. 2016

Journal of Glaucoma

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Spectral-domain optical coherence tomography for early glaucoma assessment: analysis of macular ganglion cell complex versus peripapillary retinal nerve fiber layer

Cited by 59 publications

References 30 publications

Comparative Assessment for the Ability of Cirrus, RTVue, and 3D-OCT to Diagnose Glaucoma

Comparative Assessment for the Ability of Cirrus, RTVue, and 3D-OCT to Diagnose Glaucoma

Posterior pole asymmetry analysis and retinal thickness measurements in young relatives of glaucoma patients

Identification of the Most Accurate Spectral-domain Optical Coherence Tomography Parameters in Eyes With Early High-Tension and Low-Tension Glaucoma

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