Comparative Assessment for the Ability of Cirrus, RTVue, and 3D-OCT to Diagnose Glaucoma

Abstract

PURPOSE. We compared the ability of circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular parameters obtained by three spectral-domain optical coherence tomography (SD-OCT) instruments to detect glaucoma. METHODS.We enrolled 87 normal eyes and 145 glaucomatous eyes (75 early glaucomatous eyes (EGs), mean deviation > À6 dB). Each participant was imaged using Cirrus, RTVue, and 3D-OCT to evaluate the average and quadrant cpRNFL thicknesses. The macular retinal nerve fiber layer (mRNFL), ganglion cell layer plus inner plexiform layer (GCL/IPL), and mRNFL þ GCL/IPL (ganglion cell complex [GCC]) thicknesses were analyzed. The areas under the receiver operating characteristic curves (AUCs) were compared among the instruments.RESULTS. These instruments revealed similar AUCs for the average cpRNFL and GCC thicknesses in EGs, and total all-stage glaucomatous eyes (TGs). RTVue showed better performance in the nasal cpRNFL thickness than Cirrus and 3D-OCT, and better performance in the temporal cpRNFL thickness than 3D-OCT in TGs. RTVue had a higher AUC for the superior GCC thickness compared to Cirrus and 3D-OCT in EGs, and TGs. Cirrus had higher AUCs for GCL/IPL parameters in TGs, and lower AUCs for the mRNFL parameters in EGs and TGs compared to 3D-OCT.CONCLUSIONS. The average cpRNFL and GCC thicknesses measured using these OCT instruments exhibited similar abilities in the diagnosis of glaucoma, and RTVue exhibited better diagnostic abilities than Cirrus and 3D-OCT for nasal cpRNFL, and superior GCC thicknesses. The diagnostic performance of Cirrus and 3D-OCT was different for GCL/IPL and mRNFL parameters.

Color Reflectivity Discretization Analysis of OCT Images in the Detection of Glaucomatous Nerve Fiber Layer Defects

“…Cirrus RNFL thickness measurements detected significant differences between healthy and glaucomatous eyes, which confirm previous reports using SD-OCT [31][32][33] but also using TD-OCT. [34][35][36] Most Cirrus measurements also detected significant differences between healthy and glaucoma suspect eyes, except in the temporal and nasal regions of RNFL thickness measurements.…”

Combining optical coherence tomography with visual field data to rapidly detect disease progression in glaucoma: a diagnostic accuracy study

“…[14][15][16] The optic nerve and neural rim can be examined with imaging technology to quantify the degree of structural damage; the association between image-based measurements of neural rim and RNFL loss and VF damage is well recognised [17][18][19][20][21] and the spatial relationship between the structural damage and VF loss has been established. 13,22 Imaging-based quantitative measurements have diagnostic utility [23][24][25][26][27][28][29] and numerous publications support the ability of imaging-based measurements to identify glaucoma deterioration. [30][31][32][33][34][35][36][37][38][39][40] Progressive structural change has been shown to be useful as a predictor of subsequent VF loss.…”

Diagnostic Value of Ganglion Cell-Inner Plexiform Layer Thickness in Glaucoma With Superior or Inferior Visual Hemifield Defects

“…2 Recent studies showed that the ability of the macular GCIPL parameters to diagnose glaucoma is comparable with that of the peripapillaryretinal nerve fiber layer (pRNFL) and optic nerve head parameters. [3][4][5][6][7][8] Because of the characteristic distribution of the retinal nerve fiber axons in the retina, asymmetric visual field defects often occur between the superior and inferior hemifields. Mikelberg and Drance 9 found that 70% of eyes had initial damage limited to a single hemifield and 57% still had only a single hemifield defect at the completion of follow-up.…”