Spectral-Domain Optical Coherence Tomography: A Comparison of Modern High-Resolution Retinal Imaging Systems

Kiernan, Daniel F.; Mieler, William F.; Hariprasad, Seenu M.

doi:10.1016/j.ajo.2009.08.037

Cited by 221 publications

(155 citation statements)

References 50 publications

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“…Increased amounts of data allow image registration, which aids in improved visit-to-visit measurement reproducibility. Commercially available SD OCT systems possess image acquisition speeds between 18,000 and 53,000 A-scans/sec [16].…”

Section: Spectral-domain Optical Coherence Tomographymentioning

confidence: 99%

Optical coherence tomography imaging in uveitis

et al. 2013

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Section: Spectral-domain Optical Coherence Tomographymentioning

confidence: 99%

Optical coherence tomography imaging in uveitis

et al. 2013

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“…Optik koherans tomografi (OKT) ortalama retinal sinir lifi tabakası (RSLT) kalınlığını ölçmede kullanılan noninvaziv bir optik görüntüleme yöntemidir (8). Retinaya gönderilen lazer ışınların yansımaları interferometre ile ölçülerek eş zamanlı nonkontakt kesitsel görüntüleri alınır ve makula, optik disk, retina pigment epiteli ve retina sinir lifi tabakası hakkında kantitatif bilgi verir (9).…”

Section: Introductionunclassified

Assesment of the Retinal Nerve Fiber Layer Thickness with Optical Coherence Tomography in Patients with Psoriasis

Rifaioğlu¹,

Tuzcu²,

Şen³

et al. 2014

tdd

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Amaç: Psoriasis başta deri ve eklemleri ilgilendiren ancak komorbiditeleri ile hastaların yaşam kalitesini negatif yönde etkileyen otoinflamatuvar bir hastalıktır. Göz tutulumu başlıca blefarit, konjonktivit ve keratit olmak üzere %10 oranında görülmektedir. Optik nörit ve görme alanı patolojileri ise nadiren bildirilmiştir. Çalışmamızda psoriasis hastalarında optik koherans tomografi (OKT) yöntemi ile ortalama retinal sinir lifi tabakası (RSLT) kalınlığını değerlendirmeyi amaçladık. Yöntemler: Çalışmamıza 40 psoriasis hastası ile 35 kontrol dahil edildi. Ortalama RSLT kalınlığı Cirrus SD-OCT (Carl Zeiss Meditec, Dublin, CA) cihazı ile optic disc (Optic Disc Cube 200x200 protocol) protokolü kullanılarak ölçüldü. İstatistik analizler SPSS v. 19 istatistik programı kullanılarak yapıldı. Bulgular: Hastaların ortalama psoriasis alan şiddet indeksi (PAŞİ) değeri 8,04, ortalama hastalık süreleri 8,9 idi. Ortalama RSLT kalınlıkları hasta ve kontrol grubunda farklı değildi. Ortalama RSLT kalınlıkları hastalık şiddeti ve süresi ile ilişkili değildi. Sonuç: Bu çalışma bizim bildiğimiz kadarıyla psoriasis hastalarında ortalama RSLT kalınlığının değerlendirildiği ilk çalışmadır. Psoriasis hastalarında muhtemel retinal değişiklikleri araştıracak daha geniş hasta serileri ile yapılacak çalışmalara ihtiyaç vardır. Objective: Psoriasis is an auto inflammatory disorder that affects the skin and joints. Psoriasis-related conditions that involve the eye are mainly blepharitis, conjunctivitis and keratitis and these conditions are seen in about 10% of psoriasis patients. However optic neuritis and pathologies of visual fields are rarely seen. Our study aims to investigate the mean retinal nerve fibres layer (RNFL) thickness using OCT in patient psoriasis. Methods: A total of 40 patients with psoriasis and 35 controls were included in our study. The average retinal nerve fibre layer thickness was measured using the optic disc cube protocol (200x200) and the Cirrus SD-OCT (Carl Zeiss Meditec, Dublin, CA) device. The statistical analyses were performed using the SPSS v 19 software programme. Results: The mean psoriasis area and severity index (PASI) was 8.04 and the mean disease duration was 8.9 years. The average RNFL thickness was not statistically different between the patients and the controls, and there was no correlation between the mean RNFL thickness and the severity and duration of the disease. Conclusion: To our knowledge this study is the first assessment of RNFL thickness in patient with psoriasis. However, of greater scope are needed to investigate possible retinal changes in such patients.

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“…A laser diode with 840±10 nm wavelength captures 26 000 A-scans/second, with a frame rate of 256-4096 A-scans/frame and 5 mm axial and 15 mm transverse resolution, and, similar to other SDOCT technologies, uses fast Fourier transformation of collected frequencies to improve the signal-to-noise ratio. [14][15][16][17] The ONH protocol was used to obtain both the ONH and RNFL measurements. RNFL thickness measurements were taken along 13 circular B-scans with diameters of 1.3-4.9 mm manually positioned on the optic disc to create a peripapillary RNFL thickness map.…”

Section: Sdoct Imaging and Analysismentioning

confidence: 99%

The comparison of manual vs automated disc margin delineation using spectral-domain optical coherence tomography

Iverson

Sehi

2013

Eye

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Aims To examine the impact of manual vs automated disc margin delineation on optic nerve head (ONH) and retinal nerve fiber layer (RNFL) parameters using spectraldomain optical coherence tomography (SDOCT). Methods A prospective cohort study consisting of normal, glaucoma suspect (GS) and glaucoma patients who underwent ONH and RNFL measurements using SDOCT technology (RTVue; Optovue Inc.). The retinal pigment epithelium/Bruch's membrane (RPE/BM) complex end points were automatically determined first, and were manually redefined subsequently. Analysis of variance, coefficient of variation (COV), concordance correlation coefficient (CCC), and Bland-Altman plots were used for the analyses. Results Ninety-nine eyes of 50 subjects (age 68±10 years) consisting of 36 glaucoma, 56 GS, and 7 normal eyes were included. The RNFL thickness measurements were similar (P40.05) between the two methods of demarcation, except for the inferior-nasal sector (P ¼ 0.04). For the ONH measurements, the cup-to-disc (C/D) ratio and rim area showed significant differences between the two methods (Po0.001). COV/CCC values for the ONH parameters were as follows: cup area 17.6%/0.88; cup volume 7.4%/0.91; average C/D ratio 18.1%/0.78; rim area 25.3%/ 0.69; and rim volume 42.6%/0.71, respectively. CCC/COV values for the RNFL parameters were as follows: average 2.1%/0.98; inferiortemporal quadrant 8.1%/0.79; inferior-nasal quadrant INQ quadrant 12.6%/0.67; SNQ quadrant 7.8%/0.83; and STQ quadrant 7.8%/0.88, respectively. Conclusion An overall high agreement and moderate-substantial concordance was observed between the demarcation methods. Automated disc margin delineation of SDOCT can be used reliably in clinical practice.

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Spectral-Domain Optical Coherence Tomography: A Comparison of Modern High-Resolution Retinal Imaging Systems

Cited by 221 publications

References 50 publications

Optical coherence tomography imaging in uveitis

Optical coherence tomography imaging in uveitis

Assesment of the Retinal Nerve Fiber Layer Thickness with Optical Coherence Tomography in Patients with Psoriasis

The comparison of manual vs automated disc margin delineation using spectral-domain optical coherence tomography

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