Spectral and Thermal Characterization of Mn(II), Ni(II) and Zn(II) Complexes Containing Schiff Base Ligands Towards Potential Biological Application

Dalia, M Abdel Basset; Afsan, Farhana; Hossain, Saddam; Mannan,; Haque, Md. Fazlul; Kudrat-E-Zahan,

doi:10.9734/ajocs/2018/42355

Cited by 12 publications

(11 citation statements)

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“…The second stage is the rate-limiting step of the reaction mechanism. The carbinolamine intermediate loses water through the acid or base catalysed pathways [2,19]. The water removal is important because the reaction is reversible.…”

Section: Resultsmentioning

confidence: 99%

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Simple and Efficient Green Methods Involving Microwaves and Mechanochemistry for Synthesis of a Schiff Ligand, 3, 3′-([1,1′-Biphenyl]-4,4′- Diylbis(azanylylidene))bis(indolin-2-One) With Antimicrobial Activity

BRĂTULESCU¹

2023

FARMACIA

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An azomethine organic ligand was obtained. The synthesis of 3'-([1,1'-biphenyl]-4,4'-diylbis(azanylylidene))bis(indolin-2-one) was accomplished by conventional and green protocols. Three methods have been implemented to obtain the compound. The ligand structure was established by NMR spectra, IR spectrum, UV-vis spectrum and elemental analysis. The comparative study of the experimental protocols was performed. The compound has antibacterial and antifungal activity. RezumatUn ligand organic azometinic a fost obținut. Sinteza 3,3'-([1,1'-bifenill]-4,4'-diilbis(azaniliden))bis(indolin-2-onă) a fost realizată prin protocoale experimentale convenționale și ecologice. Trei metode au fost implementate pentru obținerea compusului. Structura ligandului a fost stabilită prin spectroscopie RMN, IR, UV-vis și analiză elementală. S-a efectuat un studiul comparativ al protocoalelor implementate. Compusul prezintă activitate antibacteriană și antifungică.

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Section: Resultsmentioning

confidence: 99%

“…The conventional synthesis of Schiff bases is achieved by condensation of carbonyl compounds, aldehydes or ketones, with primary amines. The reaction is reversible, takes place in an organic solvent medium under acidic or basic catalysis during heating [19,20].…”

Section: Introductionmentioning

confidence: 99%

Simple and Efficient Green Methods Involving Microwaves and Mechanochemistry for Synthesis of a Schiff Ligand, 3, 3′-([1,1′-Biphenyl]-4,4′- Diylbis(azanylylidene))bis(indolin-2-One) With Antimicrobial Activity

BRĂTULESCU¹

2023

FARMACIA

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“…A good deal of research was carried out on synthesis, spectral, thermal studies and antimicrobial evaluation of metal complexes with these ligands. The stability and biological activities of these complexes were due to chelating property of the ligand [1][2][3][4][5][6][7] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral, Thermal Studies and Antimicrobial Evaluation of Transition Metal Complexes with Novel Schiff Base Ligand

Adhao,

Wagh

2024

Orient. J. Chem

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A novel coumarin Schiff base “(E)-7-hydroxy-4-methyl-8-(1-(1-(naphthalen-2-yl) ethylimino) ethyl)-2H-chromen-2-one” [HOMNEIEC] ligand was synthesized by the condensation of “8-acetyl-7-hydroxy-4-methyl-2H-chromen-2-one” [AHMC] with “1-(naphthalen-1-yl) ethylamine” [NEA]. The transition metal (II) ions complexes with this ligand were synthesized by a common method. The synthesized ligand and metal (II) complexes were studied using spectral (1H NMR, FTIR, Mass Spectrometry) and thermal (TGA) techniques for their structures. The 1H NMR and FTIR spectra of ligand confirm the formation of azomethine bond. The FTIR spectral data validated the formation of coordinate bond through phenolic oxygen on coumarin ring and nitrogen of azomethine with the metal ions. The m/z values in mass spectrum of ligand and its metal complexes were in agreement with their theoretical values of molecular/formula weights. The TGA thermograms suggested there are of two coordinated/lattice H2O molecules in each of the complex. The ligand and metal complexes were evaluated for their in vitro antimicrobial activities using broth microdilution method using DMSO solvent/diluent against Escherichia coli and Pseudomonas aeruginosa a gram-negative bacterial strain, Staphylococcus aureus and Streptococcus pyogenes a gram-positive bacterial strain, and Candida albicans, Aspergillus clavatus and Aspergillus niger a fungal strain. The metal complexes were found to have enhanced antimicrobial activities compare to the Schiff base ligand.

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“…They have a wide variety of pharmacological effects in addition to chemosensory, electroluminescence, optical, fluorescence, non-linear, cosmetic, material science, agricultural, and polymer industries, as well as being employed as O 2 detectors . According to the literature, the hydrogen bonding between the active centres of cell components and the imino group of Schiff bases is related to therapeutic efficacy (Dalia et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

A review on microwave-assisted synthesis and biomedical applications of Schiff bases

Kumar¹,

Sekar²,

Raju³

2023

Adv Pharma J

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Schiff bases are versatile organic compounds widely used and synthesized by the condensation reaction of a different amino compound with aldehydes or ketones known as imine (-C=N-). Schiff base ligands are considered preferential ligands as they are simply synthesized by condensation. The Schiff base facilitates coordination with transition metal ions due to the presence of an azomethine group. These compounds have a wide range of applications in the chemical and pharmaceutical industries. Schiff bases form a new class of drugs that can strengthen the immune system and also be used in the treatment of various ailments. The electrophilic carbon and nucleophilic nitrogen of the C=N imine bond provide excellent binding opportunities with a variety of nucleophiles and electrophiles, which can be exploited to inhibit particular diseases, enzymes, or DNA replication. These compounds exhibit various biological activities including antifungal, antibacterial, antitubercular, antiviral, antimalarial, antidiabetic, anticancer, antioxidant, antidiuretic, anti-inflammatory, antipyretic and anti-HIV agents. In this review, synthesis and biological applications of Schiff bases synthesised using microwave irradiation are discussed.

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Spectral and Thermal Characterization of Mn(II), Ni(II) and Zn(II) Complexes Containing Schiff Base Ligands Towards Potential Biological Application

Cited by 12 publications

References 0 publications

Simple and Efficient Green Methods Involving Microwaves and Mechanochemistry for Synthesis of a Schiff Ligand, 3, 3′-([1,1′-Biphenyl]-4,4′- Diylbis(azanylylidene))bis(indolin-2-One) With Antimicrobial Activity

Simple and Efficient Green Methods Involving Microwaves and Mechanochemistry for Synthesis of a Schiff Ligand, 3, 3′-([1,1′-Biphenyl]-4,4′- Diylbis(azanylylidene))bis(indolin-2-One) With Antimicrobial Activity

Synthesis, Spectral, Thermal Studies and Antimicrobial Evaluation of Transition Metal Complexes with Novel Schiff Base Ligand

A review on microwave-assisted synthesis and biomedical applications of Schiff bases

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