Spectral analysis of the electroencephalogram in the developing rat

Bronzino, Joseph D.; Siok, Chester J.; Austin, Kevin; Austin-LaFrance, R.J.; Morgane, Peter J.

doi:10.1016/0165-3806(87)90050-2

Cited by 17 publications

(12 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results are comparable to data obtained from mammalian species. For example, Bowersox, Floyd, and Dement (1984) described an age-related decrease in lower frequency (␦ band) activity in male cats and Bronzino, Siok, Austin, Austin-Lafrance, & Morgane (1987) found similar trends in the frontal cortex of rats, although these trend effects did not reach statistical significance. A somewhat comparable finding in human work is that of the trend of decreasing relative power over time in lower frequency (␦ and ) bands shown during development (Anokhin, Birbaumer, Lutzenberger, Nikolaeva, & Vogel, 1996;Feinberg, Thode, Chugani, & March, 1990).…”

Section: Discussionmentioning

confidence: 77%

EEG as a measure of developmental changes in the chicken brain

et al. 2000

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 77%

EEG as a measure of developmental changes in the chicken brain

et al. 2000

View full text Add to dashboard Cite

“…In addition, the individual linear spectra in the windows 0.25-21 Hz during these selected intervals and the last 5 min of the control period were normalized to a value of 1.00 by dividing each measured spectral value in the plot (0.25-21 Hz) by the sum total of all the values in the plot (i.e. total power), yielding a measure of relative power (Bronzino et al 1987). These relative power spectra were averaged within the selected intervals for each animal, and then for each group (Fig.…”

Section: Methodsmentioning

confidence: 99%

Effects of L-701,324, a high-affinity antagonist at the N-methyl-D-aspartate (NMDA) receptor glycine site, on the rat electroencephalogram

Obrenovitch

Hardy

Zilkha

1997

Naunyn-Schmiedeberg's Arch Pharmacol

View full text Add to dashboard Cite

L-701,324 (7-chloro-4-hydroxy-3-(3-phenoxy) phenyl-2-(1H)-quinolone) is a novel, orally active antagonist at the N-methyl-D-aspartate (NMDA) receptor glycine site. As NMDA receptor antagonism is generally associated with anaesthetic effects, we have examined the electroencephalographic alterations produced by doses of L-701,324 that effectively reduce NMDA-evoked responses in vivo. Microdialysis probes incorporating an electrode were implanted in the striatum of rats and perfused with artificial cerebrospinal fluid (ACSF). Under light halothane anaesthesia, 12 consecutive depolarizations were elicited by switching to ACSF containing 200 microM NMDA for 2 or 3 min, every 20 min. NMDA-evoked depolarizations and EEG were recorded with the microdialysis electrode. L-701,324 (5 or 10 mg kg-1 i.v.) or vehicle were administered 5 min after the 3rd NMDA stimulus. L-701,324 dose-dependently inhibited NMDA-evoked depolarizations, with 10 mg kg-1 reducing these responses by 50% for at least 3 h. The average amplitude of the EEG in the window 0.25-6 Hz (low frequencies) and 6-21 Hz (high frequencies) did not change in the control group. At the higher dose of 10 mg kg-1 L-701,324 transiently increased the amplitude of low frequencies by around 20%. In contrast, both 5 and 10 mg kg-1 significantly reduced the high frequencies to around 70% of control, and this action was sustained with the higher dose. Analysis of the relative EEG power spectra confirmed a small, but persistent shift from high to low EEG frequencies. Our results suggest that L-701,324 slightly strengthened halothane anaesthesia at doses inhibiting effectively NMDA receptor function. Accordingly, the resulting anticonvulsant and neuroprotective actions of L-701,324 may not be associated with marked anaesthesia-like side-effects.

show abstract

“…2C, left). In addition, Fourier analysis of a subset of theta bouts revealed a power spectrum with a peak frequency (7.9 Hz) and form characteristic of similar analyses performed in older infants and adults (Bronzino et al, 1987;Jarosiewicz et al, 2002) (Fig. 2C).…”

Section: Similarity In the Dominant Frequency Of Infant And Adult Thetamentioning

confidence: 99%

Hippocampal Theta in the Newborn Rat Is Revealed under Conditions That Promote REM Sleep

Karlsson

Blumberg

2003

J. Neurosci.

View full text Add to dashboard Cite

Hippocampal theta activity, a high-amplitude, slow (4 -12 Hz) oscillation that occurs in a variety of behavioral contexts, is thought to emerge in infant rats only after 1 week of age. However, we report here that unanesthetized 2-and 4-d-old rats with electrodes implanted in the CA1 field of the hippocampus and tested in thermoneutral conditions exhibit theta activity. Moreover, this infant theta is characterized by the same neuronal bursting pattern and power spectrum that characterize theta in adults. Simultaneous measures of behavior and neck muscle tone indicated that bouts of theta occurred predominantly during periods of muscle atonia (with or without concurrent myoclonic twitching), indicative of REM sleep. In contrast, sharp waves were accompanied by startles (i.e., simultaneous and vigorous movement of all four limbs). These findings underscore the need for comprehensive in vivo investigations of the pharmacology, neural substrates, and behavioral correlates of hippocampal field activity in neonates.

show abstract

Spectral analysis of the electroencephalogram in the developing rat

Cited by 17 publications

References 41 publications

EEG as a measure of developmental changes in the chicken brain

EEG as a measure of developmental changes in the chicken brain

Effects of L-701,324, a high-affinity antagonist at the N-methyl-D-aspartate (NMDA) receptor glycine site, on the rat electroencephalogram

Hippocampal Theta in the Newborn Rat Is Revealed under Conditions That Promote REM Sleep

Contact Info

Product

Resources

About