Hippocampal Theta in the Newborn Rat Is Revealed under Conditions That Promote REM Sleep

Karlsson, Karl; Blumberg, Mark S.

doi:10.1523/jneurosci.23-04-01114.2003

Cited by 39 publications

(34 citation statements)

References 38 publications

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“…The different cellular mechanisms underlying the generation of neonatal theta bursts versus adult theta rhythms may account for this discrepancy. Whereas adult theta activity emerges from the interplay between excitatory and inhibitory drives (Lee et al, 1994;Hasselmo, 2005), the neonatal theta bursts may be intrinsically generated (Karlsson and Blumberg, 2003) and involve subcortical triggers in the absence of "classical" GABAergic inhibition (Ben-Ari, 2002). Modification of the hippocampal activity after the diminishment of cholinergic input to the Hipp affected the prefrontal SB and NG differently as the global SAP lesion of all cholinergic nuclei.…”

Section: Selective Immunotoxic Lesion Of Cholinergic Neurons In the Mmentioning

confidence: 99%

Cholinergic Control in Developing Prefrontal–Hippocampal Networks

Janiesch¹,

Krüger²,

Poschel³

et al. 2011

J. Neurosci.

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The cholinergic drive enhances input processing in attentional and mnemonic context by interacting with the activity of prefrontalhippocampal networks. During development, acetylcholine modulates neuronal proliferation, differentiation, and synaptic plasticity, yet its contribution to the maturation of cognitive processing resulting from early entrainment of neuronal networks in oscillatory rhythms remains widely unknown. Here we show that cholinergic projections growing into the rat prefrontal cortex (PFC) toward the end of the first postnatal week boost the generation of nested gamma oscillations superimposed on discontinuous spindle bursts by acting on functional muscarinic but not nicotinic receptors. Although electrical stimulation of cholinergic nuclei increased the occurrence of nested gamma spindle bursts by 41%, diminishment of the cholinergic input by either blockade of the receptors or chronic immunotoxic lesion had the opposite effect. This activation of locally generated gamma episodes by direct cholinergic projections to the PFC was accompanied by indirect modulation of underlying spindle bursts via cholinergic control of hippocampal theta activity. With ongoing maturation and switch of network activity from discontinuous bursts to continuous theta-gamma rhythms, accumulating cholinergic projections acting on both muscarinic and nicotinic receptors mediated the transition from high-amplitude slow to low-amplitude fast rhythms in the PFC. By exerting multiple actions on the oscillatory entrainment of developing prefrontal-hippocampal networks, the cholinergic input may refine them for later gating processing in executive and mnemonic tasks.

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Section: Selective Immunotoxic Lesion Of Cholinergic Neurons In the Mmentioning

confidence: 99%

Cholinergic Control in Developing Prefrontal–Hippocampal Networks

Janiesch¹,

Krüger²,

Poschel³

et al. 2011

J. Neurosci.

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“…Prior observations of freely moving infant rats indicated that SPWs and startles typically cooccur (Karlsson and Blumberg, 2003), suggesting a causal link between the two events. Because single-ended electrodes were used in that study, it was not possible to detect a phase reversal in the SPW signal so as to confirm that the events being recorded were indeed SPWs (e.g., as opposed to events generated in the neocortex and transmitted passively to the hippocampus).…”

mentioning

confidence: 99%

On the co‐occurrence of startles and hippocampal sharp waves in newborn rats

Karlsson¹,

Mohns²,

Prisco³

et al. 2006

Hippocampus

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Hippocampal sharp waves (SPWs) are among the earliest neural population patterns observed in infant mammals. Similarly, startles are among the earliest behavioral events observed. Here we provide evidence indicating that these two events are linked mechanistically soon after birth in freely moving and head-fixed 1-4-day-old rats. EMG electrodes and intrahippocampal silicon depth electrodes were used to detect the presence of startles and SPWs, respectively. In intact pups, the majority of sharp waves were preceded by startles (average latency: 161 ms). When the hippocampal formation was surgically separated from the brainstem, however, sharp waves and startles still occurred, but now independently. In addition, unrelated to startles or SPWs, gamma oscillations were detected in several subjects, as were neocortical "spindles" that propagated passively into the hippocampus. The co-occurrence of sharp waves and startles provides the opportunity for Hebbian changes in synaptic efficacy and, thus, is poised to contribute to the assembly of neural circuits early in development.

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“…In 17 additional pups (P1-P6), two anchor bars were fixed to the skull under isoflurane anaesthesia. After recovery, the head was restrained by the skull bars and the body was surrounded by a cotton nest, mimicking the presence of littermates 28,29 . An array of eight electrodes was placed in the same cortical depth in S1 so that at least some of them recorded units.…”

mentioning

confidence: 99%

A physical map of the chicken genome

Wallis

Aerts

Groenen

et al. 2004

Nature

192

110

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the muscular system and provide metric coordinates for sensation. As the initially slow-conducting thalamo-cortical and long-range motor-sensory connections develop 3,25 , the temporal prolongation of sensory feedback by the self-generated spindle may assist in strengthening the new connections, thus contributing to the establishment of sensorimotor coordination. A MethodsNeocortical recordings were made from freely moving and anaesthetized neonatal rats (post-natal days (P) 1-8; n ¼ 45) 27

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Hippocampal Theta in the Newborn Rat Is Revealed under Conditions That Promote REM Sleep

Cited by 39 publications

References 38 publications

Cholinergic Control in Developing Prefrontal–Hippocampal Networks

Cholinergic Control in Developing Prefrontal–Hippocampal Networks

On the co‐occurrence of startles and hippocampal sharp waves in newborn rats

A physical map of the chicken genome

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