Spectral analysis of neocortical and hippocampal EEG in the protein malnourished rat

Bronzino, Joseph D.; Austin, Kevin; Siok, Chester J.; Córdova, Carmen; Morgane, Peter J.

doi:10.1016/0013-4694(83)90280-8

Cited by 22 publications

(6 citation statements)

References 18 publications

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“…Some preliminary EEG studies in AN revealed theta waves patterns in frontal hemispheres of these subjects, suggesting a cortical slow wave pattern in AN [14]. This alteration could be consequent to malnutrition as suggested by previous electroencephalographic studies [15]. Nevertheless, other authors hypothesized that the detection of low values in parietooccipital delta waves and frontomedian alpha activity in AN patients compared to healthy controls may represent a specific neurobiological characteristic of this disorder and not exclusively a consequence of malnutrition [16].…”

Section: Introductionmentioning

confidence: 72%

The song of Anorexia Nervosa: a specific evoked potential response to musical stimuli in affected participants

et al. 2020

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Research applying the EEG to AN is still limited, even though in other psychiatric disorders it permitted to find out the allmarks of the disorder. The aim of the study was to explore whether EEG recorded basal activity and reactivity to musical stimulation differs in anorexia nervosa (AN) as compared to healthy subjects (HS). Methods: Twenty female subjects (respectively 10 with AN and 10 HS) were administered a battery of psychometric tests and underwent EEG under three different conditions: 1) at baseline; 2) after a generic music stimulation; and 3) after a favorite music stimulation. EEGs of AN patients showed higher absolute amplitude of cortical slow waves (theta) in the parieto-occipital and temporal derivations, as far as for a deficit in the beta band. Results: They showed a higher N100 latency and a reduced P300 latency compared to HS. While N100 and P300 latency was sensitive to the musical stimulus in HS group, the AN group showed no difference after music stimulation. Conclusion: These data suggest that AN is accompanied by a state of brain hyperarousal with abnormal reactivity to environmental which is similar to the state of control subjects after musical stimulation. If confirmed, this finding may have treatment implications.

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Section: Introductionmentioning

confidence: 72%

The song of Anorexia Nervosa: a specific evoked potential response to musical stimuli in affected participants

et al. 2020

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“…A substantial body of information on the effects of protein malnutrition on cortical and hippocampal electroencephalograms, assessed by power spectral analysis, has been obtained by Austin, Bronzino, Galler, Morgane and colleagues (Bronzino et al 1980, 1983, 1986Morgane et al 1985). Additional assessment has been made of synaptic potentiation in dentate gyrus ) and of electrographic and behavioural measures of hippocampal kindling , a state in which neuronal excitability is enhanced, facilitating an epileptic seizure.…”

Section: Protein Malnutrition and Developmental Neurophysiologymentioning

confidence: 99%

Nutrition and neurodevelopment: mechanisms of developmental dysfunction and disease in later life

Dauncey

Bicknell

1999

Nutr. Res. Rev.

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Nutrition plays a central role in linking the ®elds of developmental neurobiology and cognitive neuroscience. It has a profound impact on the development of brain structure and function and malnutrition can result in developmental dysfunction and disease in later life. A number of diseases, including schizophrenia, may be related to neurodevelopmental insults such as malnutrition, hypoxia, viruses or in utero drug exposure. Some of the most signi®cant ®ndings on nutrition and neurodevelopment during the last three decades, and especially during the last few years, are discussed in this review. Attention is focused on the underlying cellular and molecular mechanisms by which diet exerts its effects. Randomized intervention studies have revealed important effects of early nutrition on later cognitive development, and recent epidemiological ®ndings show that both genetics and environment are risk factors for schizophrenia. Particularly important is the effect of early nutrition on development of the hippocampus, a brain structure important in establishing learning and memory, and hence for cognitive performance. A major aim of future research should be to elucidate the molecular mechanisms underlying nutritionally-induced impairment of neurodevelopment and speci®cally to determine the mechanisms by which early nutritional experience affects later cognitive performance. Key research objectives should include: (1) increased understanding of mechanisms underlying the normal processes of ageing and neurodegenerative disorders; (2) assessment of the role of susceptibility genes in modulating the effects of early nutrition on neurodevelopment; and (3) development of nutritional and pharmaceutical strategies for preventing and/or ameliorating the adverse effects of early malnutrition on long-term programming.

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“…This finding does not support data of Grunwald et al (2001) who found lower theta power in the right parietal region in AN patients, interpreted as a sign of cortical dysfunction. The increased amount of slow activity could be a sign of malnutrition (Bronzino et al, 1983), although at the time of the investigation the patients were not in wasting phase and their body weight was normal. The possibility of long lasting effects of malnutrition is further supported by non-linear analysis of the same data, which revealed decreased dimensional complexity of the EEG in AN patients, independent of taste conditions (Toth et al, in press).…”

mentioning

confidence: 98%

Effects of sweet and bitter gustatory stimuli in anorexia nervosa on EEG frequency spectra

Toth

Túry

Gáti

et al. 2004

International Journal of Psychophysiology

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Spectral analysis of neocortical and hippocampal EEG in the protein malnourished rat

Cited by 22 publications

References 18 publications

The song of Anorexia Nervosa: a specific evoked potential response to musical stimuli in affected participants

The song of Anorexia Nervosa: a specific evoked potential response to musical stimuli in affected participants

Nutrition and neurodevelopment: mechanisms of developmental dysfunction and disease in later life

Effects of sweet and bitter gustatory stimuli in anorexia nervosa on EEG frequency spectra

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