Spectral analysis of induced color change on periodically nanopatterned silk films

Amsden, Jason J.; Perry, Hannah; Boriskina, Svetlana V.; Gopinath, Ashwin; Kaplan, David L.; Negro, Luca Dal; Omenetto, Fiorenzo G.

doi:10.1364/oe.17.021271

Cited by 61 publications

(50 citation statements)

References 25 publications

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“…Standard periodic grating biosensors provide a distinct change either in the intensity of diffracted light or in the frequency of optical resonances in response to changes in the refractive index of the surrounding environment (8).…”

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confidence: 99%

Spatial and spectral detection of protein monolayers with deterministic aperiodic arrays of metal nanoparticles

Lee

Amsden²,

Boriskina

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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Light scattering phenomena in periodic systems have been investigated for decades in optics and photonics. Their classical description relies on Bragg scattering, which gives rise to constructive interference at specific wavelengths along well defined propagation directions, depending on illumination conditions, structural periodicity, and the refractive index of the surrounding medium. In this paper, by engineering multifrequency colorimetric responses in deterministic aperiodic arrays of nanoparticles, we demonstrate significantly enhanced sensitivity to the presence of a single protein monolayer. These structures, which can be readily fabricated by conventional Electron Beam Lithography, sustain highly complex structural resonances that enable a unique optical sensing approach beyond the traditional Bragg scattering with periodic structures. By combining conventional dark-field scattering micro-spectroscopy and simple image correlation analysis, we experimentally demonstrate that deterministic aperiodic surfaces with engineered structural color are capable of detecting, in the visible spectral range, protein layers with thickness of a few tens of Angstroms.biosensing | colorimetric fingerprint | deterministic aperiodic system | nanophotonics

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confidence: 99%

Spatial and spectral detection of protein monolayers with deterministic aperiodic arrays of metal nanoparticles

Lee

Amsden²,

Boriskina

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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“…11 Silk fibers, extracted from the silkworm cocoons, can be processed into various forms including silk solutions, 12 gels, 13 foams, 14 and especially films. 15,16 This variety of processing options enables its use as a supporting and packaging material for implanted micromedical devices. Additionally, silk films can be patterned ͑in both two-dimensional and three-dimensional͒ to realize a number of optical elements such as diffractive gratings 17 and wave guides 18 within the IMDs.…”

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confidence: 99%

Gold nanoparticle-doped biocompatible silk films as a path to implantable thermo-electrically wireless powering devices

Tao

Siebert

Brenckle

et al. 2010

Applied Physics Letters

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In this paper, we report on gold nanoparticle (GNP) doped silk films as an implantable and degradable heating element activated by light, which can be potentially used for wireless powering of implanted microdevices. Proof-of-concept experiments have been conducted by casting a GNP doped silk film on a miniature thermal-power chip, which generates ∼20 mW when illuminated by a green laser with an output power of 450 mW/mm2 at 532 nm.

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“…Gratings are produced by pouring silk fibroin solution to a master mold, allowing it to dry, and detaching the silk layer to form a freestanding grating. A silk grating was shown to have a sensitivity in the refractive index change of n = 0.007, which corresponds to a glucose concentration of 5% [83]. In another demonstration [84], the matrix silk was mixed with hemoglobin lysed from red blood cells, and the diffraction intensity depended on the absorption induced by oxygenation.…”

Section: Diffraction Grating Reflectorsmentioning

confidence: 99%

Toward biomaterial-based implantable photonic devices

et al. 2017

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Optical technologies are essential for the rapid and efficient delivery of health care to patients. Efforts have begun to implement these technologies in miniature devices that are implantable in patients for continuous or chronic uses. In this review, we discuss guidelines for biomaterials suitable for use in vivo. Basic optical functions such as focusing, reflection, and diffraction have been realized with biopolymers. Biocompatible optical fibers can deliver sensing or therapeutic-inducing light into tissues and enable optical communications with implanted photonic devices. Wirelessly powered, light-emitting diodes (LEDs) and miniature lasers made of biocompatible materials may offer new approaches in optical sensing and therapy. Advances in biotechnologies, such as optogenetics, enable more sophisticated photonic devices with a high level of integration with neurological or physiological circuits. With further innovations and translational development, implantable photonic devices offer a pathway to improve health monitoring, diagnostics, and light-activated therapies.

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Spectral analysis of induced color change on periodically nanopatterned silk films

Cited by 61 publications

References 25 publications

Spatial and spectral detection of protein monolayers with deterministic aperiodic arrays of metal nanoparticles

Spatial and spectral detection of protein monolayers with deterministic aperiodic arrays of metal nanoparticles

Gold nanoparticle-doped biocompatible silk films as a path to implantable thermo-electrically wireless powering devices

Toward biomaterial-based implantable photonic devices

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