Gold nanoparticle-doped biocompatible silk films as a path to implantable thermo-electrically wireless powering devices

Tao, Hu; Siebert, Sean; Brenckle, Mark A.; Averitt, R. D.; Cronin‐Golomb, Mark; Kaplan, David L.; Omenetto, Fiorenzo G.

doi:10.1063/1.3486157

Cited by 26 publications

(29 citation statements)

References 35 publications

(29 reference statements)

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“…For example, gold nanoparticles were incorporated into silk fi lms to achieve an implantable and degradable heating element activated by light, which possesses potential for thermal therapy for in vivo medical applications, such as tumor removal or pain relief. [ 88 ] More recently, the fabrication of a fully dissolvable wireless heating device was reported, which consists of a serpentine resistor and a power-receiving coil, both made of Mg, on the silk substrate ( Figure 7 ). [ 36 ] The Mg heater was protected through being encapsulated in a silk "pocket", which can be used to program the lifetime of the device.…”

Section: Resorbable Substrates For Biodegradable Electronicsmentioning

confidence: 99%

Silk Fibroin for Flexible Electronic Devices

et al. 2015

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Flexible electronic devices are necessary for applications involving unconventional interfaces, such as soft and curved biological systems, in which traditional silicon-based electronics would confront a mechanical mismatch. Biological polymers offer new opportunities for flexible electronic devices by virtue of their biocompatibility, environmental benignity, and sustainability, as well as low cost. As an intriguing and abundant biomaterial, silk offers exquisite mechanical, optical, and electrical properties that are advantageous toward the development of next-generation biocompatible electronic devices. The utilization of silk fibroin is emphasized as both passive and active components in flexible electronic devices. The employment of biocompatible and biosustainable silk materials revolutionizes state-of-the-art electronic devices and systems that currently rely on conventional semiconductor technologies. Advances in silk-based electronic devices would open new avenues for employing biomaterials in the design and integration of high-performance biointegrated electronics for future applications in consumer electronics, computing technologies, and biomedical diagnosis, as well as human-machine interfaces.

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Section: Resorbable Substrates For Biodegradable Electronicsmentioning

confidence: 99%

Silk Fibroin for Flexible Electronic Devices

et al. 2015

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“…28 Doped silk protein films with gold nanoparticles can be activated by light, powering implanted devices. 93 As mentioned in a prior section, powering implantable devices, with batteries for example, will require replacement or maintenance.…”

Section: Thermal Conductive Bioelectronicsmentioning

confidence: 99%

Protein-Based Bioelectronics

Torculas

Medina

Wang

et al. 2016

ACS Biomater. Sci. Eng.

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The desire for flexible electronics is booming, and development of bioelectronics for health monitoring, internal body procedures, and other biomedical applications is heavily responsible for the growing market. Most current fabrication techniques for flexible bioelectronics, however, do not use materials that optimize both biocompatibility and mechanical properties. This review explores flexible electronic technologies, fabrication methods, and protein materials for biomedical applications. With favorable sustainability and biocompatibility, naturally-derived proteins are an exceptional alternative to synthetic materials currently used. Many proteins can take on various forms, such as fibers, films, and scaffolds. The fabrication of resistors and organic solar cells on silk has already been proven, and optoelectronics made of collagen and keratin have also been explored. The flexibility and biocompatibility of these materials along with their proven performance in electronics make them ideal materials in the advancement of biomedical devices.

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“…Simple fabrication techniques such as single step transfers of metal micro patterns to silk films under ambient conditions is very appealing because it allows the simultaneous fabrication of microstructures over large areas of flexible silk films with high precision. Others have demonstrated that functionalized silk films doped with gold nanoparticles (Au-NP) that are light-activated heating elements which when interfaced with thermo-electronic components can wirelessly power micro devices [93]. Au-NP doped silk films were interfaced to thermoelectric chips by solution casting the polymer solution onto the active area of the chip.…”

Section: Regenerative Engineering and Limb Replacementmentioning

confidence: 99%

Regenerative engineering and bionic limbs

James

Laurencin

2015

Rare Met.

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Amputations of the upper extremity are severely debilitating, current treatments support very basic limb movement, and patients undergo extensive physiotherapy and psychological counselling. There is no prosthesis that allows the amputees near-normal function. With increasing number of amputees due to injuries sustained in accidents, natural calamities and international conflicts, there is a growing requirement for novel strategies and new discoveries. Advances have been made in technological, material and in prosthesis integration where researchers are now exploring artificial prosthesis that integrate with the residual tissues and function based on signal impulses received from the residual nerves. Efforts are focused on challenging experts in different disciplines to integrate ideas and technologies to allow for the regeneration of injured tissues, recording on tissue signals and feed-back to facilitate responsive movements and gradations of muscle force. A fully functional replacement and regenerative or integrated prosthesis will rely on interface of biological process with robotic systems to allow individual control of movement such as at the elbow, forearm, digits and thumb in the upper extremity. Regenerative engineering focused on the regeneration of complex tissue and organ systems will be realized by the cross-fertilization of advances over the past thirty years in the fields of tissue engineering, nanotechnology, stem cell science, and developmental biology. The convergence of toolboxes crated within each discipline will allow interdisciplinary teams from engineering, science, and medicine to realize new strategies, mergers of disparate technologies, such as biophysics, smart bionics, and the healing power of the mind. Tackling the clinical challenges, interfacing the biological process with bionic technologies, engineering biological control of the electronic systems, and feed-back will be the important goals in regenerative engineering over the next two decades.

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Gold nanoparticle-doped biocompatible silk films as a path to implantable thermo-electrically wireless powering devices

Cited by 26 publications

References 35 publications

Silk Fibroin for Flexible Electronic Devices

Silk Fibroin for Flexible Electronic Devices

Protein-Based Bioelectronics

Regenerative engineering and bionic limbs

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