Spectral analysis of heart rate variability in the assessment of autonomic diabetic neuropathy

Pagani, Massimo; Malfatto, Gabriella; Pierini, Simona; Casati, Rodolfo; Masu, A; Poli, M.; Guzzetti, Stefano; Lombardi, Federico; Cerutti, S.; Malliani, Alberto

doi:10.1016/0165-1838(88)90078-1

Cited by 352 publications

(194 citation statements)

References 15 publications

Supporting

Mentioning

158

Contrasting

Unclassified

Order By: Relevance

“…In addition, heart-rate variability (HRV) and, more recently, the sensitivity of spontaneous baroreflex control of the heart rate (baroreflex sensitivity, BRS), have been used to assess autonomic dysfunction as well. It has been proposed that these measures might be even more sensitive than the Ewing battery [4,5,6,7].…”

mentioning

confidence: 99%

Measures of cardiovascular autonomic nervous function: agreement, reproducibility, and reference values in middle age and elderly subjects

et al. 2003

View full text Add to dashboard Cite

Aims/hypothesis. Currently, three categories of cardiovascular autonomic nervous function measures are used: classic Ewing-test measures, measures of heartrate variability (HRV), and measures of baroreflex sensitivity (BRS). Little is known about the agreement between these measures, and reference and reproducibility values for these measures have not been reported within the same group. Methods. As part of the Hoorn Study, 631 subjects aged 50 to 75 participated in a study of autonomic nervous function. Cardiac cycle duration (RR interval) and continuous finger arterial pressure were measured under three conditions: during spontaneous breathing, during six deep breaths over 1 min, and during an active change in position from lying to standing. From these readings, ten measures of autonomic function were assessed (mean heart rate, three Ewing test measures, five HRV measures and one BRS measure). Results. Regression analysis in a healthy subgroup (n=191) showed sex differences for two of the ten measures and seven measures decreased with age. Therefore, appropriate age-specific and sex-specific reference values were calculated. Reproducibility (n=39) of most measures was moderate, with a reliability coefficient of around 50%. Agreement between the measures of autonomic nervous function varied greatly, between 0% and 87%. The HRV-power ratio measure and the blood pressure changes in the lyingto-standing test showed the lowest agreement with all other measures. Conclusion/Interpretation. This study provides agespecific and sex-specific reference values for a wide range of different autonomic function measures in an elderly population. Agreement among the different measures varied widely and reproducibility was only moderate. [Diabetologia (2003) 46:330-338] Keywords Aging, agreement, baroreflex, diabetes mellitus, heart-rate variability, nervous system, autonomic, reference values, reproducibility.

show abstract

mentioning

confidence: 99%

Measures of cardiovascular autonomic nervous function: agreement, reproducibility, and reference values in middle age and elderly subjects

et al. 2003

View full text Add to dashboard Cite

show abstract

“…[11][12][13][14][15] These methods are able to detect early abnormalities in the autonomic modulation of the cardiovascular system. [16][17][18][19] When evaluated in the time domain, the heart rate variability was reduced in chronic STZ-diabetic rats. 12,20 In another study, Fazan et al 19 observed reduction in the arterial pressure (AP) and heart rate (HR) variability, measured either as the standard deviation or by spectral analysis in chronic STZ-diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

“…In humans with DM, spectral analysis of HR disclosed significant changes in the cardiovascular variability in the frequency domain, which were apparent even before changes in all other standard cardiovascular parameters. 17 Administration of STZ is a well-established method to induce diabetes in rodents, 21 producing a number of cardiovascular changes such as hypotension, bradycardia, decreased AP variability, and impairment of the reflex control of circulation. 4,19,22,23 Since the administration of STZ to Wistar rats induces a diabetic state that is not accompanied by hypertension, 11 its use in spontaneously hypertensive rats (SHR) can produce an animal model more closely related to human diabetes.…”

Section: Introductionmentioning

confidence: 99%

Autonomic Modulation of Arterial Pressure and Heart Rate Variability in Hypertensive Diabetic Rats

Farah

Angelis

Joaquim

et al. 2007

Clinics

View full text Add to dashboard Cite

modulation of arterial pressure and heart rate variability in hypertensive diabetic rats. Clinics. 2007;62(4):477-82. OBJECTIVE:The aim of the present study was to evaluate the autonomic modulation of the cardiovascular system in streptozotocin (STZ)-induced diabetic spontaneously hypertensive rats (SHR), evaluating baroreflex sensitivity and arterial pressure and heart rate variability. METHODS: Male SHR were divided in control (SHR) and diabetic (SHR+DM, 5 days after STZ) groups. Arterial pressure (AP) and baroreflex sensitivity (evaluated by tachycardic and bradycardic responses to changes in AP) were monitored. Autoregressive spectral estimation was performed for systolic AP (SAP) and pulse interval (PI) with oscillatory components quantified as low (LF:0.2-0.6Hz) and high (HF:0.6-3.0Hz) frequency ranges. RESULTS: Mean AP and heart rate in SHR+DM (131±3 mmHg and 276±6 bpm) were lower than in SHR (160±7 mmHg and 330±8 bpm). Baroreflex bradycardia was lower in SHR+DM as compared to SHR (0.55±0.1 vs. 0.97±0.1 bpm/mmHg). Overall SAP variability in the time domain (standard deviation of beat-by-beat time series of SAP) was lower in SHR+DM (3.1±0.2 mmHg) than in SHR (5.7±0.6 mmHg). The standard deviation of the PI was similar between groups. Diabetes reduced the LF of SAP (3.3±0.8 vs. 28.7±7.6 mmHg2 in SHR), while HF of SAP were unchanged. The power of oscillatory components of PI did not differ between groups. CONCLUSIONS: These results show that the association of hypertension and diabetes causes an impairment of the peripheral cardiovascular sympathetic modulation that could be, at least in part, responsible for the reduction in AP levels. Moreover, this study demonstrates that diabetes might actually impair the reduced buffer function of the baroreceptors while reducing blood pressure.

show abstract

“…HRV is usually studied from the RR time series, either by time-domain methods (Kleiger et al 1993), nonlinear dynamics (Wada et al 1993), or spectral analysis (Pagani et al 1986). HRV analysis has been applied, for example, to study the risk of cardiac electrical instability after myocardial infarction (Bigger et al 1991), to diagnose diabetic neuropathy (Pagani et al 1988), to assess re-innervation after cardiac transplantation (Sands et al 1989) and to evaluate exercise training (Arai et al 1989).…”

Section: Introductionmentioning

confidence: 99%

Variations in breathing patterns increase low frequency contents in HRV spectra

2000

View full text Add to dashboard Cite

Abstract. This paper shows that variations in breathing patterns broaden heart rate variability (HRV) spectral bands and increase the power amplitude of low-frequency bands. Because of these influences, spectral markers for HRV signals, such as the quotient between spectral power at different frequency bands, should be compared only under controlled breathing conditions or after considering the effect of variations in breathing patterns.

show abstract

Spectral analysis of heart rate variability in the assessment of autonomic diabetic neuropathy

Cited by 352 publications

References 15 publications

Measures of cardiovascular autonomic nervous function: agreement, reproducibility, and reference values in middle age and elderly subjects

Measures of cardiovascular autonomic nervous function: agreement, reproducibility, and reference values in middle age and elderly subjects

Autonomic Modulation of Arterial Pressure and Heart Rate Variability in Hypertensive Diabetic Rats

Variations in breathing patterns increase low frequency contents in HRV spectra

Contact Info

Product

Resources

About