SPECT imaging of the stomach: comparison with barostat, and effects of sex, age, body mass index, and fundoplication

Bouras, Ernest P.; Delgado-Aros, Sílvia; Camilleri, Michael; Castillo, E. J.; Burton, Duane D.; Thomforde, George M.; Chial, Heather J.

doi:10.1136/gut.51.6.781

Cited by 198 publications

(201 citation statements)

References 28 publications

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“…Using the AVW 3.0 (Biomedical Imaging, Mayo Foundation, Rochester, MN, USA) image processing libraries, a three-dimensional rendering of the stomach was obtained and its volume (mL) calculated. There is high intra-observer reproducibility to measure GV with this technique (Bouras et al 2002). The inter-individual coefficient of variation (COV INTER ) for all subjects in a study from our laboratory (n = 433) was 32.6 % fasting, 16.0 % fed, and 19.0 % for the D volume fed-fasting.…”

Section: Gastric Emptying Study With Scintigraphymentioning

confidence: 97%

Association of melanocortin 4 receptor gene variation with satiation and gastric emptying in overweight and obese adults

et al. 2014

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Melanocortin 4 receptor (MC4R) has a major role in energy homeostasis. The rs17782313 polymorphism, mapped 188 kb downstream from MC4R, has been associated with satiety, higher body mass index (BMI) and total calorie intake in adults. To assess the association of rs17782313 with gastric functions, satiation, or satiety, we studied 178 predominantly Caucasian overweight and obese people: 120 females, 58 males; mean BMI 33.4 ± 5.3 kg/m 2 (SD); age 37.7 ± 11.2 years. Quantitative traits assessed were gastric emptying (GE) of solids and liquids; fasting and postprandial gastric volume; satiation by maximum tolerated volume and 4 symptoms by 100-mm visual analog scales (VAS); and satiety by ad libitum buffet meal. Associations of genotype and quantitative traits were assessed by analysis of covariance (using gender and BMI as covariates), based on a dominant [TC (n = 72) -CC (n = 12) vs. TT (n = 94)] genetic model. rs17782313(C) was associated with postprandial satiation symptoms (median D total VAS 26.5 mm, p = 0.036), reduced proportion of solid GE at 2 h (median D 6.7 %, p = 0.008) and 4 h (median D 3.2 %, p = 0.006), and longer t (median D 6 min, p = 0.034). Associations of rs17782313 with obesity may be explained by reduced satiation and GE. The role of MC4R mechanisms in satiation and gastric function deserves further study.

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Section: Gastric Emptying Study With Scintigraphymentioning

confidence: 97%

Association of melanocortin 4 receptor gene variation with satiation and gastric emptying in overweight and obese adults

et al. 2014

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“…In previous studies, magnetic resonance imaging (Ajaj et al, 2004), three-dimensional computed tomography, and single-photon emission computed tomography (SPECT) (Bouras et al, 2002) were used to assess the gastric accommodation reflex of the proximal stomach. However, no simple and useful method exists for the clinical evaluation of this phenomenon.…”

Section: Introductionmentioning

confidence: 99%

Simple and non-invasive assessment of the accommodation reflex of the proximal stomach

Kusunoki

Haruma

Hara

et al. 2010

J Smooth Muscle Res

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Background: Impaired gastric accommodation of the proximal stomach is one of the major pathophysiological mechanisms in functional dyspepsia (FD). However, no useful method exists for the clinical evaluation of this phenomenon. Aim: The aim of the present study was to establish a simple and non-invasive method for evaluating the accommodation reflex of the proximal stomach. Methods: Nine healthy subjects received up to 1,700 mL water (stepwise administration in 100-mL increments) using a nasogastric tube while they were in a supine position. To assess the meal-induced gastric accommodation reflex, we measured the cross-sectional area of the proximal stomach via ultrasonography (US) at 3-min intervals after administration of water. We also measured the pressure of the water column using the same tube. Then, we administrated up to 400 mL of water in 100-mL increments and measured the area of the proximal stomach in 44 FD patients with early satiation (the measurements were performed at intervals of 3-min), and we compared the results with those for 44 healthy subjects. Results: The incremental changes in the area of the proximal stomach corresponded well with the amount of water administered. The area of the proximal stomach increased, but the antral area and the intragastric pressure remained relatively stable. After administration of more than 100 ml water, the area of the proximal stomach in healthy subjects was significantly greater than that in FD patients.

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“…Measurement of the volume changes under isobaric circumstances provides insight in the response of the proximal stomach to different stimuli, ie, a meal. More recently, noninvasive imaging techniques have been employed to study gastric volume changes (5)(6)(7). In a previous study (8) a good correlation between barostat and magnetic resonance imaging (MRI) with respect to gastric volumes and dynamic volume changes in healthy volunteers under fasting conditions and in response to glucagon (gastric relaxation) and erythromycin (antral contractions) was shown.…”

mentioning

confidence: 98%

Gastric volume changes in response to a meal: Validation of magnetic resonance imaging versus the barostat

Haans

Zwart

Eilers

et al. 2011

Magnetic Resonance Imaging

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Purpose: To determine the accuracy of magnetic resonance imaging (MRI) volume scans: 1) to measure known meal volumes in vitro, and 2) to compare volume changes in response to a meal measured with the barostat with those measured with MRI in vivo.Materials and Methods: Polyethylene bags were filled with known volumes and MRI volume scans were performed to determine the accuracy of the volume measurements. Barostat measurements and MRI volume scans were performed simultaneously in 14 healthy subjects before and up to 90 minutes after ingestion of a liquid meal.Results: In vitro MRI-determined volumes showed an excellent linear relationship (r ¼ 0.995, P < 0.001) with actual meal volumes. Although fasting gastric volume, postprandial gastric volume, and relaxation volume measured with MRI were significantly larger compared to volumes measured with the barostat, volumes determined with both techniques showed excellent correlation.

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SPECT imaging of the stomach: comparison with barostat, and effects of sex, age, body mass index, and fundoplication

Cited by 198 publications

References 28 publications

Association of melanocortin 4 receptor gene variation with satiation and gastric emptying in overweight and obese adults

Association of melanocortin 4 receptor gene variation with satiation and gastric emptying in overweight and obese adults

Simple and non-invasive assessment of the accommodation reflex of the proximal stomach

Gastric volume changes in response to a meal: Validation of magnetic resonance imaging versus the barostat

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