“…Filter performance was evaluated using established speckle-reduction performance metrics [6,9,12,13], including SNR, contrast-tonoise ratio (CNR), and equivalent number of looks (ENL), which is a measure of the smoothness of a homogeneous region of interest. The following definitions for these image quality metrics were used [6,9,12,13]: (1) where F lin is the linear magnitude image, is the variance of F lin in a background noise region, μ b and are the mean and variance of the same background noise region, μ h and are the mean and variance of all the homogeneous regions of interest (H), and finally μ r and are the mean and variance of all the regions of interests (R), including the homogeneous regions (H). Following earlier work [12], except for the SNR calculations, all the other parameters were computed from the logarithmic OCT images.…”