Specific Unresponsiveness of Recirculating Lymphocytes after Exposure to Histocompatibility Antigen in F1 Hybrid Rats

Ford, W. L.; Atkins, Robert C.

doi:10.1038/newbio234178a0

Cited by 101 publications

(57 citation statements)

References 13 publications

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“…With the exception of experiments using the in vitro 5-bromo-2-deoxyuridine technique (12,13). in vivo depletion of alloreactivity by "filtration" of T cells from blood to lymph in appropriate hosts (31) gives basically similar results (8)(9)(10).…”

Section: Resultssupporting

confidence: 65%

H-2 restriction as a consequence of intentional priming: T cells of fully allogeneic chimeric mice as well as of normal mice respond to foreign antigens in the context of H-2 determinants not encountered on thymic epithelial cells.

Stockinger¹,

Pfizenmaier²,

Hardt³

et al. 1980

Proc. Natl. Acad. Sci. U.S.A.

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ABSTRACIFully allogeneic chimeras were able to develop in vitro alloantigen-specific, as well as H-2-restricted, Sendai virus-specific cytotoxic T-lymphocyte (CTL) responses. Depending on the immunization regimen used, Sendai virus-specific CTL responses were restricted to the H-2 antigens of either the stem cell donor or the thymus. Similarly, unprimed splenic T cells of normal mice were found to contain CTL-precursor cells that specifically reacted against Sendai virus or trinitrophenyl derivatives in the context of allogeneic major histocompatibility complex determinants that had not been encountered during their thymic differentiation. A frequency analysis of allogeneically versus syngeneically restricted virus-specific CTL precursors present in splenic T cells showed a ratio of about 1 to 6. These results provide evidence that H-2 restriction of trinitrophenyl-or Sendai virus-specific T cells is

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Section: Resultssupporting

confidence: 65%

H-2 restriction as a consequence of intentional priming: T cells of fully allogeneic chimeric mice as well as of normal mice respond to foreign antigens in the context of H-2 determinants not encountered on thymic epithelial cells.

Stockinger¹,

Pfizenmaier²,

Hardt³

et al. 1980

Proc. Natl. Acad. Sci. U.S.A.

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“…Several studies consistent with the concept of ASRL have already been mentioned (1,2,6). This concept has also been invoked to explain recent experiments of Ford (9) and Hay, Cahill, and Trnka (10).…”

Section: Comparison Of the Unresponsive State Induced In Tdl Spleenmentioning

confidence: 57%

“…This might explain why, in earlier studies of ours (1) and others (2), where relatively lower priming doses of antigen were used in systems similar to the present, only partial states of unresponsiveness were observed. Ford and Atkins (6) reported that an almost complete depletion of specifically reactive lymphocytes resulted when parental TDL were passaged for 1-2 days through sublethally irradiated F1 rats. The high dose of antigen provided by the irradiated hosts in their system was presumably an important factor in the degree of depletion observed.…”

Section: Comparison Of the Unresponsive State Induced In Tdl Spleenmentioning

confidence: 99%

Effect of Recent Antigen Priming on Adoptive Immune Responses

Sprent

Miller

1974

The Journal of Experimental Medicine

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When thoracic duct lymphocytes (TDL) or mesenteric lymph node (MLN) cells from mice primed 1 day before with either sheep erythrocytes (SRC) or horse erythrocytes (HRC) were transferred together with both SRC and HRC to irradiated mice, antibody responses measured 7 days later could not be detected to the priming antigen but were high to the other antigen. Furthermore, this unresponsiveness of TDL and MLN to the priming antigen could not be abrogated by delaying antigen challenge of the transferred cells for 1–2 wk. Previous work had shown that short-term priming with antigen also induced specific unresponsiveness in spleen cells on adoptive transfer. Unresponsiveness in these cells, however, was only of temporary duration, full recovery in the reactivity of the cells being observed when challenge with the priming antigen on transfer was delayed for 5 or more days. Since the present work showed that such recovery from initial unresponsiveness on transfer was unique to spleen cells and did not apply to TDL or MLN, it appeared that different mechanisms were responsible for the unresponsiveness in the three populations. It is proposed that the unresponsiveness detected in TDL and MLN cells in the present study resulted from a deficiency of antigen-reactive cells, these cells having been recruited to the spleen, i.e., a region of antigen concentration. This concept of antigen-induced selective recruitment of circulating lymphocytes was supported by evidence that 51Cr-labeled heterologous erythrocytes indeed localized largely in the spleen after intravenous injection but not in MLN.

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“…If Cy-A did effect suppression of the immune response by the deletion of responsive T cell populations, it would be necessary to postu late that sufficient numbers of antigen-reac tive cells are available subsequently to mount an immune response which is not only identical to the normal primary re sponse but also occurs without an interven ing time lag. This seems unlikely in view of the known biology of the cells which react to the major histocompatibility antigens [13,14].…”

Section: Discussionmentioning

confidence: 98%

Reversible Suppression of Allo-Antibody Production by Cyclosporin A

Denham¹,

Styles²,

Barfoot³

et al. 1980

Int Arch Allergy Immunol

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Treatment of rats with 25 mg/kg/day of cyclosporin A suppressed their immune response to skin allografts. Withdrawal of cyclosporin A treatment led to complete recovery of specific immune responsiveness and the time taken for recovery was independent of the duration of treatment. Titration of the dose of cyclosporin A administered in vivo indicated that doses of 12 mg/kg/day or less were not fully immunosuppressive.

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Specific Unresponsiveness of Recirculating Lymphocytes after Exposure to Histocompatibility Antigen in F1 Hybrid Rats

Cited by 101 publications

References 13 publications

H-2 restriction as a consequence of intentional priming: T cells of fully allogeneic chimeric mice as well as of normal mice respond to foreign antigens in the context of H-2 determinants not encountered on thymic epithelial cells.

H-2 restriction as a consequence of intentional priming: T cells of fully allogeneic chimeric mice as well as of normal mice respond to foreign antigens in the context of H-2 determinants not encountered on thymic epithelial cells.

Effect of Recent Antigen Priming on Adoptive Immune Responses

Reversible Suppression of Allo-Antibody Production by Cyclosporin A

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