Specific metabolic syndrome components predict cognition and social functioning in people with type 2 diabetes mellitus and severe mental disorders

Sánchez-Ortí, Joan Vicent; Balanzá‐Martínez, Vicent; Correa‐Ghisays, Patricia; Selva-Vera, Gabriel; Vila‐Francés, Joan; Magdalena‐Benedito, Rafael; Valenzuela, Constanza San Martín; Víctor, Víctor M.; Escribano-López, Irene; Hernández‐Mijares, Antonio; Vivas-Lalinde, Juliana; Crespo‐Facorro, Benedicto; Tabarés‐Seisdedos, Rafael

doi:10.1111/acps.13433

Cited by 10 publications

(6 citation statements)

References 57 publications

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“…The course of 0–6 months of HC (5.26%) and SC (7.61%) was very close to the above range. However, some researchers believed that SC had metabolic abnormalities first, and then obesity ( 16 ). When we focused on SC patients with a longer course of disease (over 6 months), we found that the incidence of obesity was higher than the abovementioned data of the healthy population of the national epidemiological survey.…”

Section: Discussionmentioning

confidence: 99%

Does Schizophrenia Itself Cause Obesity?

et al. 2022

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BackgroundSchizophrenia (SC) is considered the most serious of all mental disorders. Some antipsychotics are associated with weight gain and metabolic abnormalities. Whether SC itself causes obesity remains uncertain.MethodsWe collected 185 first-episode drug-naive SC and 59 healthy controls (HCs) from the Third People’s Hospital of Foshan, Guangdong, China, and distinguished their course of disease in order to understand the body mass index (BMI) and body fat metabolism of SC.ResultsWe found that excluding the drug factors, the longer the course of SC, the more obvious the increase of BMI and the higher the proportion of obesity. BMI was positively correlated with age, course of disease, fasting blood glucose (FBG), low-density lipoprotein (LDL), triglyceride (TG), and total cholesterol (TC), and negatively correlated with high-density lipoprotein (HDL). The results of regression analysis were further proof that age (B = 0.094, p < 0.001), duration (B = 0.081, p = 0.002), FBG (B = 0.987, p = 0.004), and TG (B = 0.918, p = 0.002) were the risk factors for the increase of BMI. HDL (B = –2.875, p < 0.001) was the protective factor.ConclusionSC itself can increase BMI and easily lead to obesity. We should pay more attention to the monitoring of blood metabolism indicators, so as to reduce the risk of obesity and improve the quality of life of patients.

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Section: Discussionmentioning

confidence: 99%

Does Schizophrenia Itself Cause Obesity?

et al. 2022

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“…Triglycerides were much higher in drug-naïve BD patients and BD patients taking medications than in healthy controls, and triglycerides were found to be associated with cognitive dysfunction and worse cognitive flexibility in BD ( 47 ). Triglycerides were the most accurate factor to identify individuals with greater cognitive impairment from among patients with severe mental disorders ( 48 ). In the general population, triglycerides are an independent risk factor for cardiovascular disease ( 49 ), and could serve as an independent marker for an increased risk of cardiovascular diseases in patients with type 2 diabetes mellitus ( 50 ).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and associated factors of obesity and overweight in Chinese patients with bipolar disorder

et al. 2022

Front. Psychiatry

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ObjectDespite abundant literature demonstrating a high prevalence of obesity and overweight in people with bipolar disorder (BD), little is known about this topic in China. Therefore, we assessed the prevalence and associated factors of obesity and overweight among inpatients with BD in our hospital, one of the largest public psychiatric hospitals in China.MethodsIn this retrospective, cross-sectional study, 1,169 inpatients ≥18 years with BD during 2019 were included. Obesity was defined as having a BMI ≥25 kg/m2, and overweight was defined as having a BMI from 23 kg/m2 to <25 kg/m2. Binary logistic regression analysis was performed to identify factors associated with obesity and overweight.ResultsThe prevalence of obesity and overweight was 21.0% and 32.2% in patients with BD, respectively. Compared to patients with overweight and normal weight, patients with obesity were older, had a longer duration of BD and a longer length of hospital stay, had a higher prevalence of diabetes and hypertension, and had a higher level of all metabolic indices, except for HDL cholesterol. Binary logistic regression analysis showed that duration of BD, uric acid, alanine aminotransferase (ALT), triglyceride, and LDL cholesterol were significantly associated with obesity, and male sex and uric acid level were significantly associated with overweight (p < 0.05).ConclusionsObesity and overweight were fairly prevalent in Chinese BD patients, and several factors were related to obesity and overweight. The results of the present study call for the need to implement early screening, prevention and interventions for obesity and overweight in patients with BD in China.

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“…The considerable, and recent, advances in our knowledge of the causes and regulation of the altered-metabolism-based diseases constituting the core of MS have provided consid-erable insight into their nature and the additive/complementary effects within MS [21][22][23][24][25][26]. Despite the considerable number of 'syndromic' traits involved in MS, a careful and systematic analysis of the pathogeny of most of these disorders running together has shown that they share a fairly common number of global mechanisms provoking their surge: inflammation [18,27,28].…”

Section: The Complexity Of Msmentioning

confidence: 99%

The Metabolic Syndrome, a Human Disease

Alemany

2024

IJMS

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This review focuses on the question of metabolic syndrome (MS) being a complex, but essentially monophyletic, galaxy of associated diseases/disorders, or just a syndrome of related but rather independent pathologies. The human nature of MS (its exceptionality in Nature and its close interdependence with human action and evolution) is presented and discussed. The text also describes the close interdependence of its components, with special emphasis on the description of their interrelations (including their syndromic development and recruitment), as well as their consequences upon energy handling and partition. The main theories on MS’s origin and development are presented in relation to hepatic steatosis, type 2 diabetes, and obesity, but encompass most of the MS components described so far. The differential effects of sex and its biological consequences are considered under the light of human social needs and evolution, which are also directly related to MS epidemiology, severity, and relations with senescence. The triggering and maintenance factors of MS are discussed, with especial emphasis on inflammation, a complex process affecting different levels of organization and which is a critical element for MS development. Inflammation is also related to the operation of connective tissue (including the adipose organ) and the widely studied and acknowledged influence of diet. The role of diet composition, including the transcendence of the anaplerotic maintenance of the Krebs cycle from dietary amino acid supply (and its timing), is developed in the context of testosterone and β-estradiol control of the insulin-glycaemia hepatic core system of carbohydrate-triacylglycerol energy handling. The high probability of MS acting as a unique complex biological control system (essentially monophyletic) is presented, together with additional perspectives/considerations on the treatment of this ‘very’ human disease.

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Specific metabolic syndrome components predict cognition and social functioning in people with type 2 diabetes mellitus and severe mental disorders

Cited by 10 publications

References 57 publications

Does Schizophrenia Itself Cause Obesity?

Does Schizophrenia Itself Cause Obesity?

Prevalence and associated factors of obesity and overweight in Chinese patients with bipolar disorder

The Metabolic Syndrome, a Human Disease

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