Specific Loss Power of Co/Li/Zn-Mixed Ferrite Powders for Magnetic Hyperthermia

Abstract

An important research effort on the design of the magnetic particles is increasingly required to optimize the heat generation in biomedical applications, such as magnetic hyperthermia and heat-assisted drug release, considering the severe restrictions for the human body’s exposure to an alternating magnetic field. Magnetic nanoparticles, considered in a broad sense as passive sensors, show the ability to detect an alternating magnetic field and to transduce it into a localized increase of temperature. In this context, the high biocompatibility, easy synthesis procedure and easily tunable magnetic properties of ferrite powders make them ideal candidates. In particular, the tailoring of their chemical composition and cation distribution allows the control of their magnetic properties, tuning them towards the strict demands of these heat-assisted biomedical applications. In this work, Co0.76Zn0.24Fe2O4, Li0.375Zn0.25Fe2.375O4 and ZnFe2O4 mixed-structure ferrite powders were synthesized in a ‘dry gel’ form by a sol-gel auto-combustion method. Their microstructural properties and cation distribution were obtained by X-ray diffraction characterization. Static and dynamic magnetic measurements were performed revealing the connection between the cation distribution and magnetic behavior. Particular attention was focused on the effect of Co2+ and Li+ ions on the magnetic properties at a magnetic field amplitude and the frequency values according to the practical demands of heat-assisted biomedical applications. In this context, the specific loss power (SLP) values were evaluated by ac-hysteresis losses and thermometric measurements at selected values of the dynamic magnetic fields.

Monitoring Time-Progression of Structural, Magnetic Properties of Ni Nano Ferrite During Synthesis

“…in (Figure 5) (a), shows that the magnetization behaviour is governed by Yafet-Kittel three sublattice model, described in [22], confirmed by the computed canting Mr/Ms values ranging between 0.15-0.22 reveal enhanced intergrain interactions suggesting isotropic behavior of the material [23] reveal multi-domain particles with no preferential magnetization direction. Time-dependent tunable structural, magnetic properties during synthesis are valuable in achieving optimal properties of Ni ferrite for their usage in magnetic resonance imaging [5], hyperthermia [24] for cancer treatment, photocatalysis for water purification [11].…”

Magnetoimpedance Thin Film Sensor for Detecting of Stray Fields of Magnetic Particles in Blood Vessel

“…The idea of the addition of the iron oxide MPs to the blood stream is widely discussed in the literature and it is under current investigation for many purposes of theranostics [ 10 , 40 , 41 , 42 ]. There are many ways to make magnetic particles useful from magnetic imaging and drug delivery through hyperthermia toward regenerative medicine [ 39 , 43 , 44 , 45 , 46 ]. In this particular study, we just discussed one of possible directions of such applications combining a previously proposed way of the treatment of thrombosis affected vessel [ 22 ] with the help of magnetic particles delivering thrombosis drugs.…”

Synthesis Condition and Treatment Assisted Tuning of Structural, Magnetic Properties and Bandgap of Ni Nano Ferrite

“…Hyperthermia, based on magnetic nanoparticles, can meet these requirements. Magnetic nanoparticles (e. g. -spinel nano ferrites of various Ni-based, Co-Zn, Mg-Zn, Li-based compositions [7,34] in a stable colloidal solution can be delivered non-invasively to specific tissues via external magnetic fields. On delivery, may be heated with AC magnetic fields by frequencies which do not affect healthy tissues.…”

“…A specific composition, synthesis condition, and post-preparation treatments are of use used to tune structural, magnetic properties of the nano ferrites needed for their optimum performance in hyperthermia applications. Non-equilibrium cation distribution strongly influences ferrites static, dynamic magnetic [7,34], thereby affecting SAR values. Thus, present results on NiFe 2 O 4 magnetic nanoparticles are of interest for their potential usage in hyperthermia applications.…”

“…In contrast, divalent metal ions on B site are inverse spinel, and divalent metal ions on both A, B sites are mixed ferrites. Distribution of cations can be modified to tune the properties (structural, magnetic, bandgap), can be successfully done by synthesis conditions e. g. microwave-assisted synthesis [4], specific composition [5], thermal treatment [6], is valuable for their usage for magnetic resonance imaging [5], hyperthermia [7] for cancer treatment, photocatalysis for water purification [8].…”