Specific lipase-responsive polymer-coated gadolinium nanoparticles for MR imaging of early acute pancreatitis

Zhang, Hongwu; Wang, Liqin; Xiang, Qingfeng; Zhong, Qian; Chen, Luming; Xu, Caixia; Xiang, Xianhong; Xu, Bo; Meng, Fei; Wan, Yiqian; Deng, David Y.B.

doi:10.1016/j.biomaterials.2013.09.046

Cited by 41 publications

(41 citation statements)

References 44 publications

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“…Gadolinium-impregnated PLGA microparticles have been successfully imaged as both a standard and modified polymer, which is consistent with our demonstration that gadolinium-PLGA microcylinders could be evaluated post-implantation using MRI [49][50][51]. Additionally, non-PLGA-based microparticles combined with gadolinium have been created and also appear to be suitable for use with MRI [52].…”

Section: Discussionsupporting

confidence: 66%

Clinical, Imaging and Pathological Characteristics of Brain Implanted Polylactic Co-Glycolic Acid Polymers Conjugated with Temozolomide

Hicks¹,

R²

2015

J Veterinar Sci Technol

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Definitive treatments for primary brain tumours are still sought. Slow-release local chemotherapy may provide a good effect and poly (lactide-co-glycolide) (PLGA) microcylinders could allow this. We evaluated the neurological and histopathological consequences, and MRI visibility, of PLGA microcylinders conjugated with temozolomide and gadolinium implanted in normal canine brains. Eight purpose-bred beagles had cerebral implantation of microcylinders combined with temozolomide and gadolinium. MRI was performed following implantation and 28d later prior to necropsy and brain histopathology. All adverse events were associated with implantation and resolved. Dogs with six microcylinders at 0 and 6.25% gadolinium had mild inflammation and all other dogs had greater brain inflammation, which increased with higher gadolinium concentrations and microcylinder number. Microcylinders with gadolinium were identifiable on MRI. Brain implantation of PLGA microcylinders conjugated with gadolinium and temozolomide is tolerated in healthy beagles. The lowest gadolinium percentage and microcylinder number should be used if this therapy is pursued.

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Section: Discussionsupporting

confidence: 66%

Clinical, Imaging and Pathological Characteristics of Brain Implanted Polylactic Co-Glycolic Acid Polymers Conjugated with Temozolomide

Hicks¹,

R²

2015

J Veterinar Sci Technol

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“…After activation by lipase cleavage, the insoluble chelate becomes soluble and generates an increase in relaxivity, r1 . In a rat model of acute pancreatitis, the lipase-activatable probe was successfully used for detection of early acute pancreatitis 40 . Another exciting development in highsensitivity detection is the design of hyperpolarized silica nanoparticles, which have been shown to be feasible for in vivo MRI 41 .…”

Section: Molecular Imagingmentioning

confidence: 99%

A targeted approach to cancer imaging and therapy

2014

Nature Mater

252

190

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“…The experimental AP models were induced by three IP injections of l-arginine (300 mg/100 g of body weight) as a 20% solution in 0.9% physiological saline, at an interval of 1 h, as previously described. 32 After the third injection, the animals were given food and water again. The control rats received an equal volume of 0.9% physiological saline (control group).…”

Section: Rat Ap Model and Experimental Protocolmentioning

confidence: 99%

Mannose-coated gadolinium liposomes for improved magnetic resonance imaging in acute pancreatitis

Tian¹,

Liu²,

Chen³

et al. 2017

IJN

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Background Acute pancreatitis (AP) is an acute inflammatory condition of the pancreas. The symptoms, treatment, and prognosis of mild and severe AP are different, and severe AP is a potentially life-threatening disease with a high incidence of complications and high mortality rate. Thus, it is urgent to develop an effective approach to reliably discriminate between mild and severe AP. Methods We have developed novel gadolinium-diethylenetriaminepentaacetic (Gd-DTPA)-loaded mannosylated liposomes (named thereafter M-Gd-NL) that preferably target macrophages in AP. The targeting ability of M-Gd-NL toward macrophages in AP and its ability to discriminate between mild and severe AP were evaluated. Results The liposomes were of desired particle size (~100 nm), Gd-DTPA encapsulation efficiency (~85%), and stability. M-Gd-NL and non-targeted Gd-DTPA-loaded liposomes (Gd-NL) exhibited increased relaxivity compared with Gd-DTPA. Compared with Gd-NL and Gd-DTPA, M-Gd-NL showed increased uptake in macrophages, resulting in increased T 1 imaging ability both in vitro (macrophage cell line) and in vivo (severe AP model). Importantly, M-Gd-NL had the ability to discriminate between mild and severe AP, as reflected by a significantly higher T 1 magnetic resonance imaging signal in severe AP than in mild AP. M-Gd-NL did not show severe organ toxicity in rats. Conclusion Our data suggest that M-Gd-NL had enhanced magnetic resonance imaging ability by targeting macrophages in AP and good ability to discriminate between mild and severe AP. We believe that M-Gd-NL could shed new light on the diagnosis of AP in the near future.

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Specific lipase-responsive polymer-coated gadolinium nanoparticles for MR imaging of early acute pancreatitis

Cited by 41 publications

References 44 publications

Clinical, Imaging and Pathological Characteristics of Brain Implanted Polylactic Co-Glycolic Acid Polymers Conjugated with Temozolomide

Clinical, Imaging and Pathological Characteristics of Brain Implanted Polylactic Co-Glycolic Acid Polymers Conjugated with Temozolomide

A targeted approach to cancer imaging and therapy

Mannose-coated gadolinium liposomes for improved magnetic resonance imaging in acute pancreatitis

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