A targeted approach to cancer imaging and therapy

Li, Chun

doi:10.1038/nmat3877

Cited by 251 publications

(190 citation statements)

References 67 publications

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“…By applying a vast and diverse array of nanoparticles, whose design derives from the engineering, chemistry, and medicine fields, to molecular imaging and targeted therapy, cancer nanotechnology promises solutions to several of the current obstacles facing cancer therapies [6][7][8][9][10][11][12][13].…”

Section: Cancermentioning

confidence: 99%

Nanotechnology in Cancer Diagnosis and Treatment

El-Karim¹,

El-Zahar²,

Anwar³

2015

JPP

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Nanotechnology refers to research and technology development at the atomic, molecular, and macromolecular scale, leading to the controlled manipulation and study of structures and devices with length scales in the 1-100 nanometers range. Objects at this scale, such as "nanoparticles," take on novel properties and functions that differ markedly from those seen in the bulk scale. The small size, surface tailor ability, improved solubility, and multifunctional of nanoparticles open many new research avenues for biologists. Nanoparticles are classified into inorganic nanoparticles such as gold nanoparticles and organic nanoparticles such as carbon nanotubes and dendrimers. Different types of nanoparticals such as nanocrystals, liposomes, polymeric nanoparticles, dendrimers, quantum dots and superparamagnetic nanoparticles illustrated different examples of promising nanoparticles for cancer treatment and imaging.

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Section: Cancermentioning

confidence: 99%

Nanotechnology in Cancer Diagnosis and Treatment

El-Karim¹,

El-Zahar²,

Anwar³

2015

JPP

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“…These are microsized particles coated with a lipid or polymer and filled with gas, and they cause very high reflection of sound waves compared to blood and surrounding tissue. Contrast-enhanced US with site-targeted microbubbles has been primarily used in tumor imaging [23,24]. Angiogenesis plays an important role in the development of several diseases, such as tumor growth and metastasis, coronary ischemic arterial disease, peripheral arterial disease, and ocular proliferative disease [25,26].…”

Section: Ultrasoundmentioning

confidence: 99%

Translational Imaging for Regenerative Medicine

Kelkar

Mohs

2015

Translational Regenerative Medicine

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“…Particularly, near-infrared (NIR) light-responsive nanoparticles can provide a promising strategy for the design of single theranostic nanoplatform syncretizing realtime photo-imaging with phototherapy (Huang et al 2014;Li 2014;Yuan et al 2013). Compared with other shorter-wavelength light, NIR light exhibits outstanding properties of the deeper tissue penetration and minimal tissue invasion, which make it favourable for the photoactivated theranostics (Weissleder 2001).…”

Section: Introductionmentioning

confidence: 99%

One-pot synthesis of gold nanostars using plant polyphenols for cancer photoacoustic imaging and photothermal therapy

et al. 2016

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Branched plasmonic nanostructures have been found to exhibit strong enhancement of the electromagnetic field surrounding their multibranched petals. This feature endows them with improved performance in catalysis, surface-enhanced Raman scattering, photoacoustic imaging, and photothermal therapy. Albeit several synthesis techniques have been developed, the precisely controlled growth of highly branched nanostructures with a one-pot surfactant-free procedure is still challenging. Herein, we present a simple seedless route to synthesize gold nanostars (AuNSs) using a natural plant polyphenol, gallic acid (GA), as a reducing and stabilizing agent. The size and shape of AuNSs can be tuned by simply adjusting the amount of added GA. Under the optimum condition, the as-prepared AuNSs with diameters about 100 nm exhibit strong near-infrared absorption, good photothermal efficiency, and high biocompatibility. We demonstrate that AuNSs can be utilized for simultaneous photoacoustic imaging and photothermal therapy in living cancer cells. This study highlights facile synthesized AuNSs could serve as a promising platform for cancer diagnosis and therapy.

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A targeted approach to cancer imaging and therapy

Cited by 251 publications

References 67 publications

Nanotechnology in Cancer Diagnosis and Treatment

Nanotechnology in Cancer Diagnosis and Treatment

Translational Imaging for Regenerative Medicine

One-pot synthesis of gold nanostars using plant polyphenols for cancer photoacoustic imaging and photothermal therapy

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