“…May not important principles lie hidden i observations such as these? Again, it has bedn reported that when lepers are vaccinated there is a generalized activation of leprous skin lesions, and the vaccinia skin lesions themselves are particularly severe (24,55). Also, why is it that the pyrexias of smallpox, tuberculosis, primary atypical pneumonia, and brucellosis fail to activate latent herpes simplex and give cold sores (9)?…”