Specific Inactivation of Herpes Simplex Virus by Silver Nitrate at Low Concentrations and Biological Activities of the Inactivated Virus

Shimizu, Fumio; Shimizu, Yasutomo; Kumagai, Katsuo

doi:10.1128/aac.10.1.57

Cited by 18 publications

(16 citation statements)

References 11 publications

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“…46 Similarly, silver nitrate inactivation of herpes simplex virus types 1 and 2 at concentrations 30 mmol/L was reported. 47 Another mechanism of heavy metals including silver is believed to be mediated by their ability to bind sulfhydryl groups of capsid proteins of viruses. 47 In this study, coupons from the respirator containing silver-copper based antimicrobial technology failed to show a statistically significant decontamination of MS2 compared with the controls.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the survivability of MS2 viral aerosols deposited on filtering face piece respirator samples incorporating antimicrobial technologies

Rengasamy

Fisher

Shaffer

2010

American Journal of Infection Control

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Section: Discussionmentioning

confidence: 99%

Evaluation of the survivability of MS2 viral aerosols deposited on filtering face piece respirator samples incorporating antimicrobial technologies

Rengasamy

Fisher

Shaffer

2010

American Journal of Infection Control

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“…Virus. The F strain of HSV-1 was propagated in green monkey kidney (GMK) cells as previously described (Shimizu et al, 1976). Briefly, GMK cells were infected with HSV-1 at an m.o.i, of 0.1 p.f.u./cell and incubated in Eagle's MEM containing 2~ heat-inactivated calf serum at 37 °C for 3 days.…”

Section: Methodsmentioning

confidence: 99%

Inhibition by Indomethacin of in vitro Reactivation of Latent Herpes Simplex Virus Type 1 in Murine Trigeminal Ganglia

Kurane

Tsuchiya

Sekizawa

et al. 1984

Journal of General Virology

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SUMMARYInfectious virus could no longer be detected in the trigeminal ganglia removed from mice 25 days after infection with herpes simplex virus type 1 (HSV-1) by the lip route. When the ganglia were cultured in vitro for 1 or 2 days, infectious HSV-1 was again detected in the ganglia, indicating the reactivation of latent HSV-1. The effect of indomethacin on this reactivation was examined. When the ganglia were cultivated in the presence of 5 × 10 -4 M-indomethacin, the appearance of infectious virus in the ganglia was almost completely inhibited. After removal of indomethacin, infectious virus appeared and the virus titre reached levels found in the ganglia cultured in indomethacin-free medium, indicating that the inhibition of the reactivation may not be due to the cytotoxic effect of indomethacin on the ganglionic cells. The inhibitory effect of indomethacin was only seen when it was added shortly after explantation. These results suggest that indomethacin affects some early processes of viral reactivation in the explanted ganglia. The synthesis of prostaglandins (PGE and PGB) found in the explanted ganglia was strongly suppressed by indomethacin, as was the viral reactivation. Other inhibitors of prostaglandin synthesis, i.e. tetracaine, mepacrine and mefenamic acid, also inhibited viral reactivation in the explanted ganglia. These results suggest that the inhibitory effect of indomethacin on the reactivation of latent HSV-1 may be due to the inhibition of prostaglandin synthesis, although it is possible that other cellular changes which could be caused by indomethacin contributed to the suppression of reactivation.

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“…Herpes simplex virus types I and II was reported to be inactivated by silver nitrate at concentrations of 30 μ mol l −1 or less (Shimizu et al . ). AgNPs of approximately 10 nm were demonstrated to inhibit monkeypox virus in vitro , supporting their potential use as an antiviral therapeutic agent (Rogers et al .…”

Section: Antimicrobial Activitymentioning

confidence: 97%

The silver lining: towards the responsible and limited usage of silver

Naik

Kowshik

2017

J Appl Microbiol

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SummarySilver has attracted a lot of attention as a powerful, broad spectrum and natural antimicrobial agent since the ancient times because of its nontoxic nature to the human body at low concentrations. It has been used in treatment of various infections and ulcers, storage of water and prevention of bacterial growth on the surfaces and within materials. However, there are numerous medical and health benefits of colloidal or nanosilver apart from its microbicidal ability which as yet has not been fully embraced by the medical community. These include antiplatelet activity, antioxidant effect, anticancer activity, wound healing and bone regeneration, enhancement of immunity, and increase in antibiotic efficiency. Additionally silver also provides protection against alcohol toxicity, upper respiratory tract infections and stomach ailments. Although nanosilver has been proposed for various topical applications, its usage by ingestion and inhalation remains controversial due to the lack of detailed and precise toxicity information. These beneficial properties of silver can be utilized by using silver at very low concentrations which are not harmful to the human body and environment. The following review discusses the diverse medical applications of silver and further recommends human clinical studies for its in vivo usage.

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Specific Inactivation of Herpes Simplex Virus by Silver Nitrate at Low Concentrations and Biological Activities of the Inactivated Virus

Cited by 18 publications

References 11 publications

Evaluation of the survivability of MS2 viral aerosols deposited on filtering face piece respirator samples incorporating antimicrobial technologies

Evaluation of the survivability of MS2 viral aerosols deposited on filtering face piece respirator samples incorporating antimicrobial technologies

Inhibition by Indomethacin of in vitro Reactivation of Latent Herpes Simplex Virus Type 1 in Murine Trigeminal Ganglia

The silver lining: towards the responsible and limited usage of silver

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