Specific hyposensitization in atopic dermatitis

Fuenmayor, Maria C. Di Prisco De; Champion, R.H.

doi:10.1111/j.1365-2133.1979.tb05649.x

Cited by 29 publications

(3 citation statements)

References 10 publications

(6 reference statements)

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“…These results indicate an important role for 5-HT in the regulation of the cataleptic effect of molindone and suggest that the activation of the central 5-HT-ergic system has a facilitatory effect on the catalepsy induced by molindone while inhibition of the central 5-HT-ergic system decreases the cataleptic effect of molindone. Further, our results also indicate that the central 5-HT-ergic system influences molindone-induced catalepsy in the same manner as it influences haloperidol or chlorpromazineinduced catalepsy (Kostowski et a1 1972;Gumulka et a1 1973;Carter & Pycock 1977;Balsara et a1 1979) or catalepsy induced by brain-amine depleting neuroleptics (Fuenmayor & Vogt 1979) and suggest that the central 5-HT-ergic system may be exerting an inhibitory influence on the central dopaminergic system and that the cataleptic effect of neurileptics gpparently depends on the balance between the two systems. These findingsalso concur with clinical reports.…”

supporting

confidence: 55%

Effect of drugs influencing central 5-hydroxytryptaminergic mechanisms on molindone-induced catalepsy in the rat

Nandal

Gada

et al. 1981

Journal of Pharmacy and Pharmacology

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The cataleptic action of neuroleptics is reduced after Laboratories), methysergide hydrogen maleinate lesions of the 5-hydroxytryptaminergic raphe system or (Sandoz Products Ltd)' were dissolved in distilled water depletion of 5-HT stores by p-chlorophenylalanine while L-tryptophan (Sigma) was dissolved in a minimum (Kostowski et a1 1972; Gumulka et a1 1973). However, quantity of HCI and made up to volume with distilled Costal1 et a1 (1975) have reported that lesions of the water. All agents were injected intraperitoneally, 5-HT-ergic rapht system, though effective in reducing molindone, clomipramine and quipazine in a volume the cataleptic action of haloperidol, fluphenazine, of 2 ml kg-', while methysergide and L-tryptophan were oxiperomide and spiroxatrine, had no consistent effect injected in a volume of 5 ml kg-'. Except for on the cataleptic action of the dibenzazepine neuro-L-tryptophan, doses refer to the salt. For each dose, leptics, loxapine and clothiapine, while the weak 10 animals were used. Clomipramine and methysergide cataleptic action of clozapine was potentiated, were injected 30 min and quipazine and L-tryptophan suggesting thereby that the 5-HT-ergic raphe system 60 min before molindone treatment. Control groups exerts a variable influence on the cataleptic action of received the requisite volume of vehicle intraperitoneally different neuroleptics.before receiving molindone. Results were analysed by Molindone, a dihydroindolone compound, unrelated the Mann-Whitney U-test for non-parametric data. chemically to the phenothiazines or butyrophenones, is Molindone (1.25 mg kg-' i.p.) induced no catalepsy a recently introduced neuroleptic for the treatment of while higher doses (2.5-20 mg kg-l i.p.) induced a state schizophrenia (Abuzzahab 1973;Ayd 1974). It is of sedation and dose-dependent degree of catalepsy, reported to induce catalepsy (Rubin et a1 1967) by without loss of righting reflex or apparent change in blocking striatal dopamine receptors (Bunney et a1 1975).We have investigated on molindone-induced catalepsy in the rat, the effect of pretreatment with clomipramine, a selective blocker of neuronal reuptake (Fig. 1). Doses beyond 20 mg kg-' tended to produce motor incoordination and ataxia.Clomipramine (5, 10, 20 rng kg-') did not induce catalepsy. Higher doses were not tested as they tended to produce motor incoordination and ataxia. Clomipramine pretreatment potentiated the cataleptic effect of molindone (2.5, 5.0 mg kg-') dose-dependently (Fig. 2). P~az/i/~&~/@g&~&i7'//of~&&~@&fl& gonist.Male albino rats, 120-180 g, with free access to a standard diet and tap water were used once only. During the experiments the animals were individually housed in wire netting cages at 27-30 "C in a noiseless room. All observations were made between 10 and 16 h.Catalepsy was scored according to . Animals were tested for the presence of catalepsy by placing both front limbs over a horizontal bar placed 8 cm above the bench surface. Those animals maintaining the cataleptic posture from 0 to 10 s scor...

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supporting

confidence: 55%

Effect of drugs influencing central 5-hydroxytryptaminergic mechanisms on molindone-induced catalepsy in the rat

Nandal

Gada

et al. 1981

Journal of Pharmacy and Pharmacology

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“…We believe that this may be related to the physically unpleasant nature of the treatment and to the rather ritualistic procedures involved in its administration., for example, the preparation of adrenaline, checking of resuscitation equipment and the close observation for the subsequent 2 hr. This phenomenon certainly serves to cast doubt on the validity of anecdotal observations of benefit from hyposensitization [18][19][20][21].…”

Section: Discussionmentioning

confidence: 99%

“…There is some evidence that hyposensitization treatment using injections of small quantities of house dust mite antigen extracts is beneficial in house dust miteprovoked asthma, at least in children [16.17]. A number of uncontrolled studies [18][19][20][21] have demonstrated some improvement in atopic eczema following hyposensitization with house dust mite extracts. In addition benefit was noted in concurrent atopic eczema in a double blind controlled study in children with asthma [16].…”

Section: Introductionmentioning

confidence: 99%

A double‐blind controlled trial of hyposensitization to Dermatophagoides pteronyssinus in children with atopic eczema

Glover

Atherton

1992

Clin Experimental Allergy

120

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A double-blind controlled trial of hyposensitization with tyrosine-adsorbed Dermatophagoides pteronyssinus vaccine in 24 children with atopic eczema and immediate hypersensitivity to D. pteronyssinus failed to demonstrate superiority over placebo after a standard 8 month course of treatment. In a second phase, children initially administered active treatment were randomly allocated to continue with active treatment or switched to placebo for a further 6 months. The clinical scores suggest that prolonged hyposensitization may be more effective than placebo but the numbers were too small to permit confident conclusions. A dramatic placebo effect may have served to conceal any additional therapeutic effect from active treatment.

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T Cell Defects in Atopic Dermatitis: Therapeutic Consequences

Jarisch

1981

New Trends in Allergy

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Specific hyposensitization in atopic dermatitis

Cited by 29 publications

References 10 publications

Effect of drugs influencing central 5-hydroxytryptaminergic mechanisms on molindone-induced catalepsy in the rat

Effect of drugs influencing central 5-hydroxytryptaminergic mechanisms on molindone-induced catalepsy in the rat

A double‐blind controlled trial of hyposensitization to Dermatophagoides pteronyssinus in children with atopic eczema

T Cell Defects in Atopic Dermatitis: Therapeutic Consequences

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