Specific features of the reactions of quinazoline and its 4-hydroxy and 4-chloro substituted derivatives with C-nucleophiles

Reactions of 4-methylidene-bis(1-phenyl-3-methylpyrazol-5-one) with trimethylaluminum: Synthesis, structure and catalysis for the ring-opening polymerization of ε-caprolactone

“…In particular, monovalent ligand 4-methylidene-bis(1-phenyl-3-methylpyrazol-5-one) (MBP-H) attracts our attention because of ease of preparation via a one-step reaction using commercially available quinazoline and 1-phenyl-3-methylpyrazol-5-one as starting materials [10]. In terms of coordination chemistry, the MBP − group provides O,O-bidentate chelation to stabilize main-group metal complexes, especially of sterically bulky substituents at the N-position of the pyrazole ring.…”

Synthesis of α,ω-bis(pyrazol-3-yl)alkanes: I. 1,4-bis(1-methyl- and 1-benzyl-5-chloro-1H-pyrazol-3-yl)-butanes from 1,1,10,10-Tetrachlorodeca-1,9-diene-3,8-dione and 1,1-dimethyl- or benzylhydrazine

“…1,4-Bis(1-methyl-and 1-benzyl-5-chloro-1H-pyrazol-3-yl)-butanes from 1,1,10,10-Tetrachlorodeca-1,9-diene-3,8-dione and 1,1-Dimethyl-or Benzylhydrazine Abstract-First representatives of bis-2-chloro-and 2,2-dichlorovinyl ketones, 1,10-dichlorodeca-1,9-diene-3,8-dione and 1,1,10,10-tetrachlorodeca-1,9-diene-3,8-dione, were synthesized by reaction of hexanedioyl dichloride with acetylene and 1,1-dichloroethene, respectively, in the presence of AlCl 3 . 1,1,10,10-Tetrachlorodeca-1,9-diene-3,8-dione reacted with benzylhydrazine and 1,1-dimethylhydrazine to give 1,4-bis(1-benzyl-5-chloro-1H-pyrazol-3-yl)butane and 1,4-bis(5-chloro-1-methyl-1H-pyrazol-3-yl)butane, respectively.Organic compounds containing two and more pyrazole fragments attract considerable interest from both theoretical and practical viewpoints primarily due to the possibility of using them as ligands for the preparation of polynuclear complexes and coordination polymers possessing valuable properties [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. Multitopic pyrazole-containing ligands are also used as sorbents and intermediate products for the synthesis of compounds exhibiting biological and catalytic activity, and they can be involved in self-assembly of supramolecular ensembles, etc.…”

“…Organic compounds containing two and more pyrazole fragments attract considerable interest from both theoretical and practical viewpoints primarily due to the possibility of using them as ligands for the preparation of polynuclear complexes and coordination polymers possessing valuable properties [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. Multitopic pyrazole-containing ligands are also used as sorbents and intermediate products for the synthesis of compounds exhibiting biological and catalytic activity, and they can be involved in self-assembly of supramolecular ensembles, etc.…”

“…4,4′-Bis-pyrazole systems are fairly accessible; they are synthesized by reactions of polyelectrophiles with pyrazoles, aldehydes, and ketones [13][14][15]. A number of 3(5)-methyl(ethyl)-substituted bis-pyrazoles bridged at the 5,5′(3,3′)-positions by alkanediyl, 1,4-methylenephenyl, and 1,4′-diphenyleneoxy(disulfido) spacers were obtained by reaction of the corresponding bis-β-diketones with hydrazine hydrate [16,17].…”

“…Multitopic pyrazole-containing ligands are also used as sorbents and intermediate products for the synthesis of compounds exhibiting biological and catalytic activity, and they can be involved in self-assembly of supramolecular ensembles, etc. On the other hand, organic polypyrazole ligands were studied insufficiently because of their low accessibility; therefore, search for new synthetic approaches to such compounds remains an important problem [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17].…”