Specific Effects of Different Food Components on Intestinal Motility

Schang, J. C.; Dauchel, J; Sava, P; Angel, F.; Bouchet, Patrick; Lambert, Amaury; Grenier, J F

doi:10.1159/000128034

Cited by 41 publications

(7 citation statements)

References 14 publications

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“…The more nutrients are present in food when the longer disruption of the MMC occurs. The caloric load can thus strongly affect the interdigestive pattern, especially in such species like man (188,243) and dog (54,58,233). In ruminants, relatively low-caloric load of the typical diet, especially of the hay given alone, can retain the MMC during the digestive period (29,97,153).…”

Section: Luminal Conditions and The MMCmentioning

confidence: 99%

Importance of the enteric nervous system in the control of the migrating motility complex

Romanski

2017

Acta Physiol Hung

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The migrating motility complex (MMC), a cyclical phenomenon, represents rudimentary motility pattern in the gastrointestinal tract. The MMC is observed mostly in the stomach and gut of man and numerous animal species. It contains three or four phases, while its phase III is the most characteristic. The mechanisms controlling the pattern are unclear in part, although the neural control of the MMC seems crucial. The main goal of this article was to discuss the importance of intrinsic innervation of the gastrointestinal tract in MMC initiation, migration, and cessation to emphasize that various MMC-controlling mechanisms act through the enteric nervous system. Two main neural regions, central and peripheral, are able to initiate the MMC. However, central regulation of the MMC may require cooperation with the enteric nervous system. When central mechanisms are not active, the MMC can be initiated peripherally in any region of the small bowel. The enteric nervous system affects the MMC in response to the luminal stimuli which can contribute to the initiation and cessation of the cycle, and it may evoke irregular phasic contractions within the pattern. The hormonal regulators released from the endocrine cells may exert a modulatory effect upon the MMC mostly through the enteric nervous system. Their central action could also be considered. It can be concluded that the enteric nervous system is involved in the great majority of the MMC-controlling mechanisms.

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Section: Luminal Conditions and The MMCmentioning

confidence: 99%

Importance of the enteric nervous system in the control of the migrating motility complex

Romanski

2017

Acta Physiol Hung

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“…This was demonstrated in two canine studies in 1978 [9,10] and more recently also in man [11][12][13], Studies on the effect of the chemical composition of a meal on postpran dial motility, however, have rendered inconsistent results [9,10,12,14,15], Thus it has not been settled whether or not the fat content of a meal affects postprandial motility. The physical characteristics of a meal, however, are defi nitely important in that viscosity and fiber content regu late the duration of the postprandial interval and possibly also contractile activity during the postprandial period [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Small Bowel Motor Response to Solid and Liquid Meals in Man

et al. 1997

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Interdigestive motor activity has been studied extensively both in the human and canine small intestine. The more irregular postprandial pattern, however, has rarely been studied. In particular, physiological studies in humans are lacking. Thus it is unknown whether the physical state of a meal affects the duration of the postprandial motor activity or contractile activity during the postprandial period. 8 healthy male volunteers, aged 19-38 years, underwent a single ambulatory 24-hour manometry study. During the study, volunteers had two physiological meals. The solid meal consisted of pasta with vegetables, and the liquid meal was a vanilla milk drink. The two meals were both palatable, isocaloric (660 kcal) and had an identical fat content (32%). Recordings were analyzed visually for phase III of the migrating motor complex and a validated computer program calculated the mean frequency and amplitude of contractions as well as the mean area under the curve (AUC). The postprandial period was significantly shorter after the liquid meal compared to the solid meal (196 ± 43 vs. 298 ± 23 min; p < 0.04). During the postprandial period, the mean incidence of contractions (2.0 ± 0.5 vs. 3.7 ± 0.4 min^-1; p < 0.02) and the mean AUC (132 ± 32 vs. 236 ± 27 mm Hg × s × min^-1; p < 0.02) were significantly lower after the liquid meal. The mean amplitude of contractions during the total postprandial period, however, was not significantly different between the two test meals (19.3 ± 0.6 vs. 18.6 ± 0.8 mm Hg). We conclude that human small bowel motor activity differs markedly between solid and liquid meals. Thus the postprandial pattern persists longer after solid meals, and this may have been due to the slower gastric emptying of solids as opposed to liquids. Furthermore the small bowel contracts far more frequently after solid meals.

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“…Intestinal stimuli are particularly effective. Lipids, proteins and carbohydrates all elicit postprandial-like motility when infused directly into the duodenum (Schang, Dauchel, Sava, Angel, Bouchet, Lambert & Grenier, 1978). However, whether these effects are mediated non-specifically through osomoreceptors or via receptors specific to different components of the test meals is still to be determined.…”

Section: Introductionmentioning

confidence: 99%

The effect of intraluminal tryptophan and phenylalanine on small intestinal motility in the conscious dog.

Bull¹,

Grundy²,

Scratcherd³

1985

The Journal of Physiology

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SUMMARY1. The effect of D-and L-isomers of tryptophan and phenylalanine on fasting motor activity of canine jejunum were investigated.2. Only L-tryptophan had any effect on jejunal motility. The concentration of L-tryptophan required to elicit a motor effect in 50 % of animals was estimated at 28 mM.3. 50 mM-L-tryptophan stimulated jejunal motility after a latency of 4-5 + 0-7 min. The pattern of motility was similar to that evoked by feeding but continued for only 41+5 min and failed to disrupt the normal timing of the interdigestive migrating motor complex (m.m.c.). The duration of the subsequent phase II of the complex was, however, significantly reduced.4. Multiple infusion of L-tryptophan also failed to disrupt the timing of the m.m.c. 5. These data are consistent with the hypothesis that specific breakdown components of protein digestion are implicated in the stimulation of postprandial motor activity. The mechanisms involved in the motor response to L-tryptophan are discussed.

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Specific Effects of Different Food Components on Intestinal Motility

Cited by 41 publications

References 14 publications

Importance of the enteric nervous system in the control of the migrating motility complex

Importance of the enteric nervous system in the control of the migrating motility complex

Comparison of the Small Bowel Motor Response to Solid and Liquid Meals in Man

The effect of intraluminal tryptophan and phenylalanine on small intestinal motility in the conscious dog.

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