Specific detection of peste des petits ruminants virus antibodies in sheep and goat sera by the luciferase immunoprecipitation system

Berguido, Francisco J.; Bodjo, Sanne Charles; Loitsch, Angelika; Diallo, Adama

doi:10.1016/j.jviromet.2015.10.008

Cited by 14 publications

(14 citation statements)

References 17 publications

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“…Rare proteins can be accumulated up to 10,000-fold by IP (Dwane and Kiely, 2011). Luciferase immunoprecipitation systems (LIPS) have been developed for the rapid detection of antibodies against peste des petits ruminants virus (PPRV) (Berguido et al, 2016), varicella-zoster virus (VZV) (Cohen et al, 2014), zinc transporter (ZnT8) autoantibodies (Ustinova et al, 2014), and pancreatic and duodenal homeobox 1 autoantibodies (PAA) (Donelan et al, 2013).…”

Section: Immunoprecipitationmentioning

confidence: 99%

Antibody Engineering for Pursuing a Healthier Future

et al. 2017

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Since the development of antibody-production techniques, a number of immunoglobulins have been developed on a large scale using conventional methods. Hybridoma technology opened a new horizon in the production of antibodies against target antigens of infectious pathogens, malignant diseases including autoimmune disorders, and numerous potent toxins. However, these clinical humanized or chimeric murine antibodies have several limitations and complexities. Therefore, to overcome these difficulties, recent advances in genetic engineering techniques and phage display technique have allowed the production of highly specific recombinant antibodies. These engineered antibodies have been constructed in the hunt for novel therapeutic drugs equipped with enhanced immunoprotective abilities, such as engaging immune effector functions, effective development of fusion proteins, efficient tumor and tissue penetration, and high-affinity antibodies directed against conserved targets. Advanced antibody engineering techniques have extensive applications in the fields of immunology, biotechnology, diagnostics, and therapeutic medicines. However, there is limited knowledge regarding dynamic antibody development approaches. Therefore, this review extends beyond our understanding of conventional polyclonal and monoclonal antibodies. Furthermore, recent advances in antibody engineering techniques together with antibody fragments, display technologies, immunomodulation, and broad applications of antibodies are discussed to enhance innovative antibody production in pursuit of a healthier future for humans.

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Section: Immunoprecipitationmentioning

confidence: 99%

Antibody Engineering for Pursuing a Healthier Future

et al. 2017

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“…PPR virus (PPRV), the aetiologic agent of this devastating animal viral disease is a morbillivirus of the family Paramyxoviridae [8].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic response of West African Dwarf goats infected with Peste des Petits Ruminants whose oral lesions were treated with oxytetracycline long acting and gentian violet topical spray

Ugochukwu¹,

Ugochukwu²,

Chukwu³

2017

APJTD

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“…One of the African lineages is also found in Asia (8)(9)(10). The aetiologic virus is easily transmitted by direct contact with the aerosols, secretions and/or excretions of infected animals (2,4,11).…”

Section: Introductionmentioning

confidence: 99%

Comparative Efficacy of Different Chemotherapeutic Regimens in the Treatment of Peste des Petits Ruminants in West African Dwarf Goats

et al. 2020

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The comparative efficacy of different chemotherapeutic regimes in the treatment of natural clinical infection of Peste des petits ruminants (PPR) infection in West African Dwarf (WAD) goats were determined. Twenty WAD male goats divided into five groups, of four each were used. Group 1 was the combined therapy group treated with Acyclovir, Oxytetracycline and Ivermectin, Group 2 was treated with Acyclovir only, Group 3 was treated with Ivermectin only, Group 4 was treated with Oxytetracycline only and Group 5 was left untreated. Clinical signs such as nasal and ocular discharges, emaciation, anorexia, pyrexia, ulcerative oral lesions, respiratory distress and diarrhoea were observed in these goats during the period of their acclimatization. The prominent post-mortem lesion observed was discontinuous streaks of congestion (Zebra markings) in the mucosa of the colon and rectum. The physiologic parameters (temperature, pulse rate, heart rate, and respiratory rate) were taken daily. It was observed that there was a significant increase in the temperature above normal in the untreated group, suggesting pyrexia. It was also observed that the combined therapy group showed a smaller number of mortality and thus, had a better efficacy when compared to the other chemotherapeutic agents used singly

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Specific detection of peste des petits ruminants virus antibodies in sheep and goat sera by the luciferase immunoprecipitation system

Cited by 14 publications

References 17 publications

Antibody Engineering for Pursuing a Healthier Future

Antibody Engineering for Pursuing a Healthier Future

Therapeutic response of West African Dwarf goats infected with Peste des Petits Ruminants whose oral lesions were treated with oxytetracycline long acting and gentian violet topical spray

Comparative Efficacy of Different Chemotherapeutic Regimens in the Treatment of Peste des Petits Ruminants in West African Dwarf Goats

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