Specific dermatologic features of the polycystic ovary syndrome and its association with biochemical markers of the metabolic syndrome and hyperandrogenism

Özdemir, Suna; Özdemır, Mustafa; Görkemli, Hüseyin; Kiyici, Aysel; Bodur, Sait

doi:10.3109/00016340903353284

Cited by 79 publications

(80 citation statements)

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“…Foram definidos os grupamentos ponderais de acordo com o IMC: normal (18,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)9), sobrepeso (25-30) e obesidade (>30). A pressão arterial (mmHg) foi mensurada no braço direito, com a paciente sentada, após cerca de dez minutos em repouso.…”

Section: Métodosunclassified

“…A despeito de estudos prévios abordarem o vínculo entre os elevados níveis de androgênios e as dermopatias peculiares à SOP, os conhecimentos seguem, contudo, insuficientes, nos termos em que se revelam perante a associação com os parâmetros metabólicos 18 . Ainda que vinculada à obesidade e ao diabetes tipo 2, a prevalência da AN observa certa disparidade, conforme diferentes resultados recentes.…”

Section: Métodosunclassified

“…Ainda que vinculada à obesidade e ao diabetes tipo 2, a prevalência da AN observa certa disparidade, conforme diferentes resultados recentes. Entre todas as dermatopatias relacionadas à SOP, a prevalência da AN ocupa posição ínfima (5,2%) 18 , ao contrário de estudos com porcentagens maiores, a exemplo de 64,6% 19 , particularmente focalizados nas relações com o diabetes tipo 2 20 . A discrepância envolve fatores étnicos, geográficos e, notadamente, a coexistência de múltiplas condições de risco para o diabetes.…”

Section: Métodosunclassified

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Acantose nigricante: inter-relações metabólicas inerentes à síndrome dos ovários policísticos

Ávila¹,

Borges²,

Paez³

et al. 2014

Rev. Bras. Ginecol. Obstet.

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ResumoOBJETIVO: Estabelecer a prevalência da acantose nigricante (AN) no contexto da síndrome dos ovários policísticos (SOP) e as respectivas associações com a obesidade, a resistência insulínica (RI), a insulinemia e a síndrome metabólica (SM). MÉTODOS: Em um estudo transversal e prospectivo, foram selecionadas cem pacientes acometidas pela SOP, diagnosticadas segundo o Consenso de Rotterdam (2003). O exame cutâneo incluiu, além da verificação da presença da AN, a presença do hirsutismo (escore ≥8) e da acne. Foram investigados os dados clínicos e bioquímicos, os fatores de risco cardiovascular que se fazem presentes na SM, como circunferência abdominal (CA), obesidade, hipertensão e os índices de HDL e triglicérides. O modelo de aferição da resistência insulínica foi realizado por meio do teste homeostatic model assessment of insulin resistance (HOMA-IR). RESULTADOS: A prevalência da AN (53%) mostrou correspondência significativa com o hirsutismo (p=0,02), o índice de massa corpórea (IMC) (p<0,01), a insulinemia basal (p<0,01), o HOMA-IR (p<0,01) e a SM (p<0,05). A SM alcançou a prevalência de 36% e associou-se significativamente apenas com a AN (p<0,01). Conquanto ausente o diabetes mellitus, sobressaem as conotações do HOMA-IR alterado (p=0,01) com a SM (p<5%) e a AN (p<0,01). CONCLUSÕES: A AN integra o quadro fenotípico grave da SOP como mais um signo previsível dos riscos da doença cardiovascular. Abstract PURPOSE:To establish the prevalence of acanthosis nigricans (AN) within the context of polycystic ovary syndrome (PCOS) and its associations with obesity, insulin resistance, insulinemia, and metabolic syndrome (MS). METHODS: A cross-sectional prospective study was conducted on 100 patients with PCOS diagnosed according to the Rotterdam Consensus (2003). The skin test included, in addition to the detection of the presence of AN, the presence of hirsutism (score ≥8) and acne. In addition to clinical and biochemical data, we investigated cardiovascular risk factors present in MS such as abdominal circumference, obesity, hypertension and HDL and triglyceride levels. Insulin resistance was determined by the HOMA-IR test. RESULTS: The prevalence of AN (53%) was significantly correlated with hirsutism (p=0.02), body mass index (p<0.01), basal insulinemia (p<0.01), (HOMA-IR) (p<0.01), and MS (p<0.01). The prevalence of MS reached 36% and was significantly associated only with AN (p<0.01). Although diabetes mellitus was absent, there was a significant association of altered HOMA-IR (p<0.01) with MS (p<5%) and AN (p<0.01). CONCLUSION: AN is part of the severe phenotypic profile of PCOS as an additional predictable sign of the risks of cardiovascular disease.

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Section: Métodosunclassified

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Acantose nigricante: inter-relações metabólicas inerentes à síndrome dos ovários policísticos

Ávila¹,

Borges²,

Paez³

et al. 2014

Rev. Bras. Ginecol. Obstet.

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“…Acne is a pilosebaceous unit disorder, characterized by excess amount of sebum production, abnormal follicular epithelial differentiation, desquamated epithelial cells clogging the pilosebaceous follicles and inflammation [8,9]. and though acne is not a good marker of hyperandrogenism, It was found in 53% of PCOS patients representing the second most common symptom [10]. Although the diagnostic criteria of PCOS does not include obesity, almost half of women with the condition were found to be overweight or obese [11].…”

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confidence: 99%

Effect of Diet Control Therapy on the Dermatological Symptoms of Obese Polycystic Ovarian Syndrome Women: Repeated Measure Design

Mahmoud¹

2018

IJPR

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Background: Polycystic ovarian syndrome (PCOS) is the most common endocrinal disorder in female causing metabolic, cutaneous, and reproductive disorders.Purpose: This repeated measure study was designed to investigate the effect of diet control therapy on hyperandrogen symptoms (Acne & Hirsutism) in obese PCOS women.Subjects and Methods: Thirty PCOS obese women were recruited, their age ranged from 20 to 30 years and their BMI ranged from 30 to 34.9 kg/m 2 . All of them received diet control therapy, and were evaluated before, after 12 weeks and after 24 weeks of therapy through measuring their weight, C-reactive protein, luteinizing hormone (LH) / follicular stimulating hormone (FSH) ratio, androgen excess symptoms (modified Ferryman-Gallwey (mFG) scoring system & global acne grading system (GAGS).Results: Repeated Measure MANOVA showed a statistically significant difference (P < 0.05) between the pretreatment compared to after therapy (in both 12 and 24 weeks) in LH/FSH ratio, CRP, mFG and GAGS, however no significance difference was found between 12 weeks and 24 weeks for all the dependent variables. As well as, Pearson's product-moment correlation revealed a weak positive correlation between C-reactive protein and androgen excess symptoms (Acne & Hirsutism). Conclusion:Three months following the recommended diet control therapy is an effective therapy for improving the cutaneous symptoms and fertility through the hormonal variables of PCOS patients. Diet control therapy for another consequent three months is also recommended to keeping this improvement.

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“…A higher percentage (40.1%) of prevalence occurredFurtheremore, MetS is a complex phenotype that correlates with many clinical conditions besides CVD and diabetes, including chronic low-grade inflammation, oxidative stress 7 , hyperuricemia 8 , hypertension 9 , dyslipidemia 9 , hyperandrogenism 10 , hepatic steatosis 11 , nonalcoholic fatty liver disease (NAFLD) 12 , impaired glucose tolerance 13 , hypogonadism 14 , and vascular dementia 15 .…”

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confidence: 99%

Untitled

2017

IJPSR

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Background: Metabolic syndrome (MetS) is a cluster of diseases, including hypertension, obesity, dyslipidemia, and hyperglycemia. We therefore aimed to estimate MetS prevalence and to determine risk factors for MetS. Methods: In the present study, we recruited 209 adult Tunisian MetS patients (57 males and 152 females, mean age 58.9±10.7 years) matched by gender and ethnic origin to 193 healthy individuals (31males and 162 females, mean age 50.3±10.6 years). All subjects underwent anthropometric and biochemical examinations. Results: Interestingly, the prevalence of MetS was 21.89% in males and 78.1% in females. Notable increase in the dyslipidemia (64.1%), hypertension (77%), and obesity (83.73%) in patients with MetS were seen. In addition, insulin resistance, hyperglycemia, abnormal lipid profiles, increased free fatty acids, and lower serum adiponectin concentrations were all associated with MetS. Conclusion: We suggest that the MetS is highly prevalent among patients group than healthy subjects. Modification of lifestyle factors, even later in life, has considerable potential for primary prevention of the MetS.

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Specific dermatologic features of the polycystic ovary syndrome and its association with biochemical markers of the metabolic syndrome and hyperandrogenism

Abstract: Acne and androgenic alopecia are not good markers for the hyperandrogenism in PCOS. Hirsutism appears to be strongly related with hyperandrogenism and metabolic abnormalities in PCOS women.

Cited by 79 publications

References 30 publications

Acantose nigricante: inter-relações metabólicas inerentes à síndrome dos ovários policísticos

Acantose nigricante: inter-relações metabólicas inerentes à síndrome dos ovários policísticos

Effect of Diet Control Therapy on the Dermatological Symptoms of Obese Polycystic Ovarian Syndrome Women: Repeated Measure Design

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