Effect of Diet Control Therapy on the Dermatological Symptoms of Obese Polycystic Ovarian Syndrome Women: Repeated Measure Design

Abstract

Background: Polycystic ovarian syndrome (PCOS) is the most common endocrinal disorder in female causing metabolic, cutaneous, and reproductive disorders.Purpose: This repeated measure study was designed to investigate the effect of diet control therapy on hyperandrogen symptoms (Acne & Hirsutism) in obese PCOS women.Subjects and Methods: Thirty PCOS obese women were recruited, their age ranged from 20 to 30 years and their BMI ranged from 30 to 34.9 kg/m 2 . All of them received diet control therapy, and were evaluated before, after 12 weeks and after 24 weeks of therapy through measuring their weight, C-reactive protein, luteinizing hormone (LH) / follicular stimulating hormone (FSH) ratio, androgen excess symptoms (modified Ferryman-Gallwey (mFG) scoring system & global acne grading system (GAGS).Results: Repeated Measure MANOVA showed a statistically significant difference (P < 0.05) between the pretreatment compared to after therapy (in both 12 and 24 weeks) in LH/FSH ratio, CRP, mFG and GAGS, however no significance difference was found between 12 weeks and 24 weeks for all the dependent variables. As well as, Pearson's product-moment correlation revealed a weak positive correlation between C-reactive protein and androgen excess symptoms (Acne & Hirsutism). Conclusion:Three months following the recommended diet control therapy is an effective therapy for improving the cutaneous symptoms and fertility through the hormonal variables of PCOS patients. Diet control therapy for another consequent three months is also recommended to keeping this improvement.