Specific Cholinesterase Inhibitors: A Potential Tool to Assist in Management of Alzheimer Disease

Grieg, Nigel H.; Kamal, Mohammad Amjad; Jabir, Nasimudeen R.; Tabrez, Shams; Nasim, Faiz-ul-Hassan; Abuzenadah, Adel M.; Aliev, Gjumrakch

doi:10.1016/b978-0-12-803959-5.50006-4

Cited by 6 publications

(6 citation statements)

References 94 publications

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“…The primary therapeutic stratagem against AD till date engrosses the use of cholinesterase inhibitors (ChEIs) which increase residual cholinergic activity, improve cognition and global performance, and reduce behavioral disturbances. For the treatment of AD, some potent and quickly absorbed acetyl cholinesterase inhibitors (AChEIs), such as phenserine, tolserine, and esolerineare, are reported in the scientific literature . Several naturally derived AChEIs have also been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Cholinesterase targeting by polyphenols: A therapeutic approach for the treatment of Alzheimer’s disease

2018

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Alzheimer's disease (AD) is a progressive irreversible neurodegenerative disorder characterized by excessive deposition of β-amyloid (Aβ) oligomers, and neurofibrillary tangles (NFTs), comprising of hyperphosphorylated tau proteins. The cholinergic system has been suggested as the earliest and most affected molecular mechanism that describes AD pathophysiology. Moreover, cholinesterase inhibitors (ChEIs) are the potential class of drugs that can amplify cholinergic activity to improve cognition and global performance and reduce psychiatric and behavioral disturbances. Approximately, 60%-80% of all cases of dementia in the world are patients with AD. In view of the continuous rise of this disease especially in the aged population, there is a dire need to come up with a novel compound and/or mixture that could work against this devastating disease. In this regard, the best is to rely on natural compounds rather than synthetic ones, because natural compounds are easily available, cost-effective, and comparatively less toxic. To serve this purpose, lately, scientific community has started exploring the possibility of using different polyphenols either solitary or in combination that can serve as therapeutics against AD. In the current article, we have summarized the role of various polyphenols, namely quercetin, resveratrol, curcumin, gallocatechins, cinnamic acid, caffeine, and caffeic acid as an inhibitor of cholinesterase for the treatment of AD. We have also tried to uncover the mechanistic insight on the action of these polyphenols against AD pathogenicity.

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Section: Introductionmentioning

confidence: 99%

Cholinesterase targeting by polyphenols: A therapeutic approach for the treatment of Alzheimer’s disease

2018

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“…Acetylcholinesterase enzyme (AChE) is predominantly found in the cholinergic synapses while butyrylcholinesterase enzyme (BuChE) is a non-substrate specific enzyme that can be found throughout the body including in glial cells. Low levels of AChE and high levels of BuChE have been reported as AD progresses [ 16 ]. Acetylcholinesterase enzyme inhibitors (AChEi) including galanthamine ( 1 ) and donepezil are drugs that have been approved by the Food and Drug Agency (FDA) to manage AD.…”

Section: Cholinesterase Inhibitory Potential Of Natural-product-dementioning

confidence: 99%

Potential of Naturally Derived Alkaloids as Multi-Targeted Therapeutic Agents for Neurodegenerative Diseases

Kong

Tay

et al. 2021

Molecules

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Alkaloids are a class of secondary metabolites that can be derived from plants, fungi and marine sponges. They are widely known as a continuous source of medicine for the management of chronic disease including cancer, diabetes and neurodegenerative diseases. For example, galanthamine and huperzine A are alkaloid derivatives currently being used for the symptomatic management of neurodegenerative disease. The etiology of neurodegenerative diseases is polygenic and multifactorial including but not limited to inflammation, oxidative stress and protein aggregation. Therefore, natural-product-based alkaloids with polypharmacology modulation properties are potentially useful for further drug development or, to a lesser extent, as nutraceuticals to manage neurodegeneration. This review aims to discuss and summarise recent developments in relation to naturally derived alkaloids for neurodegenerative diseases.

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“…One such enzyme, which is a plasma choline esterase, is the pseudo-cholinesterase known as butyryl cholinesterase (BChE). There are potent AChE drugs that are readily absorbed, such as AChE inhibitors esolerineare, phenserine, and tolserine [58,59]. While inhibiting the AChE enzymes could offer insight into protective mechanisms, nothing yet found is quite perfect.…”

Section: Ad-protective Foods and The Microbiotamentioning

confidence: 99%

The Microbiota–Gut–Brain Axis–Heart Shunt Part II: Prosaic Foods and the Brain–Heart Connection in Alzheimer Disease

et al. 2020

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There is a strong cerebrovascular component to brain aging, Alzheimer disease, and vascular dementia. Foods, common drugs, and the polyphenolic compounds contained in wine modulate health both directly and through the gut microbiota. This observation and novel findings centered on nutrition, biochemistry, and metabolism, as well as the newer insights we gain into the microbiota-gut-brain axis, now lead us to propose a shunt to this classic triad, which involves the heart and cerebrovascular systems. The French paradox and prosaic foods, as they relate to the microbiota-gut-brain axis and neurodegenerative diseases, are discussed in this manuscript, which is the second part of a two-part series of concept papers addressing the notion that the microbiota and host liver metabolism all play roles in brain and heart health.

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Specific Cholinesterase Inhibitors: A Potential Tool to Assist in Management of Alzheimer Disease

Cited by 6 publications

References 94 publications

Cholinesterase targeting by polyphenols: A therapeutic approach for the treatment of Alzheimer’s disease

Cholinesterase targeting by polyphenols: A therapeutic approach for the treatment of Alzheimer’s disease

Potential of Naturally Derived Alkaloids as Multi-Targeted Therapeutic Agents for Neurodegenerative Diseases

The Microbiota–Gut–Brain Axis–Heart Shunt Part II: Prosaic Foods and the Brain–Heart Connection in Alzheimer Disease

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