Specific Antibodies in Heart-Disease

Ehrenfeld, E. N.; Gery, Igal; Davies, A.M.

doi:10.1016/s0140-6736(61)92066-9

Cited by 74 publications

(13 citation statements)

References 5 publications

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“…In previous experimental studies we were not able to show a relationship between the presence of circulating anti-heart antibodies and myocardial damage [10]. This has also been the case in a number of different clinical studies of other diseases [11,12]. However, the elution of anti-heart antibodies from the myocardium in cases of heart transplantation where an immune reaction existed [13], as well as the results of immunofluorescent studies where bound anti-heart antibodies were found [14] are suggestive of a relationship between the presence of these antibodies and myocardial damage.…”

Section: Discussionmentioning

confidence: 72%

Morphological and Immunological Studies in Valvular Heart Surgery

Laufer¹,

Garcés²,

N³

et al. 1970

Pathobiology

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Light and electronmicroscopical studies were performed on myocardial samples, obtained from the atrium, papillary muscle, anterior wall of left ventricle and the operated valves. Degenerative verrucous endocardiosis and bacterial endocarditis were encountered but no histological signs of rheumatic activity were found. No specific diagnostic electronmicroscopical findings were present and the ultra-structural changes present included alterations in the mitochondria, an increase in the number of fat droplets, a focal increase in glycogen and focal muscle disruption and necrosis. The detection of anti-heart antibodies by indirect immunofluorescent studies and their possible relation to myocardial damage are discussed. In addition, the importance of myocardial changes, the presence of small myocardial scars and the increase in interstitial collagen tissue are reviewed in relation to myocardial function and it is suggested that they can be used as a prognostic index of myocardial function. It is also suggested that earlier operation of diseased valves be performed in order to prevent further myocardial damage and impairment of myocardial function.

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Section: Discussionmentioning

confidence: 72%

Morphological and Immunological Studies in Valvular Heart Surgery

Laufer¹,

Garcés²,

N³

et al. 1970

Pathobiology

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“…A question arises as to whether limited sensitivity is a methodical matter, or whether it concerns a lower ability of dogs to respond immunologically to artificial necrosis. Finally, E hrenfeld et al [15] have found antibodies against myocardium in only 24 of 150 patients by means of the passive hemagglutination method. D avies and G ery [16] have studied the possibility of patients' serum reaction on antigenic heart tissue in various types of heart diseases and came to the conclusion, that only a limited number of people had ability to form circulating antibody.…”

Section: Discussionmentioning

confidence: 99%

Immunological Response to the Revascularisation of Experimental Myocardial Infarction

Jezková¹,

Bartoš²,

Pokorný³

1971

J Vasc Res

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“…Although no mention was made of clinical effects, histologic changes similar to those described above were noted. The presence of circulating autoantibodies to heart have been described in a number of cardiac disorders in man including the post myocardial infarction and post pericardiotomy syndrome [3,10,11], myocardial infarction [4] and rheumatic fever [5,8]. No abnormality as a result of these antibodies has been established.…”

Section: Discussionmentioning

confidence: 99%