A statistically significant incidence of antibodies against antigen from normal arteries and blood vessels changed by an atherosclerotic process was found in patients in the acute phase of thromboangiitis obliterans. No such incidence was found in a control group of healthy blood donors and in patients with other diseases. These findings of antibodies can significantly help in the differential diagnosis of the acute phase of thromboangiitis obliterans. It is possible that estimations of antibodies may also be of some value in patients with atherosclerosis obliterans where especially the neutralization test could be important for differential diagnosis of atherosclerosis.
Although lyophilization reduces the bacterial population in plasma, some species survive for several months. Sensitivity or resistance to lyophilization in plasma is a characteristic of each morphological type, with gram-negative species being more sensitive to destruction than cocci or sporulating gram-positive species. Reconstituted preparations of lyophilized plasma must be incubated for 24 hr to prevent false-negative sterility tests. The killing process in lyophilized plasma continues with time if the preparations are stored at room temperature. Strict asepsis must be realized during processing of plasma because lyophilization alone does not destroy the microorganisms present.
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