Specific anion effects on the hydration and tribological properties of zwitterionic phosphorylcholine-based brushes

Yu, Yunlong; Yao, Yongchao; Lin, Simone van; Beer, Sissi de

doi:10.1016/j.eurpolymj.2019.01.013

Cited by 26 publications

(17 citation statements)

References 63 publications

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“…1 They are popular building blocks in the design of functional surface coatings due to their versatility and simplicity to manipulate. 2,3 For example, these brushes have been employed as smart sensors [4][5][6] or to manage surface lubricity [7][8][9] and adherence. 10,11 Surface wettability is also tuned straightforwardly with polymer brushes, which has resulted in the development of moisture management systems 12 and self-cleaning surfaces.…”

Section: Introductionmentioning

confidence: 99%

The role of entropy in wetting of polymer brushes

2021

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Section: Introductionmentioning

confidence: 99%

The role of entropy in wetting of polymer brushes

2021

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“…The carriers varied with structure and topology based on ILs have been designed via amphiphilic linear polymers, i.e., from vinylimidazolium [ 20 ], imidazolium [ 21 ], pyridinium [ 22 ] or guanidinium–type IL [ 23 ]. Numerous reports have been devoted to the use of phosphorylcholine IL as a co-monomer to obtain linear block copolymers [ 24 , 25 ], whereas those with graft topology and containing ionic units, i.e., imidazolium [ 26 ] or choline-type IL [ 12 , 27 ] in the side chains, have been investigated with significantly lower attention. In the case of the ionic polymer structure, drugs can be carried in ionic form as counterions, i.e., nicotinic, salicylic, ampicillin, naproxen, ibuprofenate anions [ 28 , 29 , 30 ], as well as in nonionic form as loaded guests [ 31 ], or both forms as the systems for combined therapy [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Biological In Vitro Evaluation of PIL Graft Conjugates: Cytotoxicity Characteristics

Niesyto

Łyżniak

Skonieczna

et al. 2021

IJMS

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In vitro cytotoxicity of polymer-carriers, which in the side chains contain the cholinum ionic liquid units with chloride (Cl) or pharmaceutical anions dedicated for antituberculosis therapy, i.e., p-aminosalicylate (PAS) and clavulanate (CLV), was investigated. The carriers and drug conjugates were examined, in the concentration range of 3.125–100 μg/mL, against human bronchial epithelial cells (BEAS-2B) and adenocarcinomic human alveolar basal epithelial cells (A549) as an experimental model cancer cell line possibly coexisting in tuberculosis. The cytotoxicity was evaluated by MTT test and confluency index, as well as by the cytometric analyses, including Annexin-V FITC apoptosis assay. The polymer systems showed supporting activity towards the normal cells and no tumor progress, especially at the highest concentration (100 μg/mL). The analysis of cell death did not show meaningful changes in the case of the BEAS-2B, whereas in the A549 cell line, the cytostatic activity was observed, especially for the drug-free carriers, causing death in up to 80% of cells. This can be regulated by the polymer structure, including the content of cationic units, side-chain length and density, as well as the type and content of pharmaceutical anions. The results of MTT tests, confluency, as well as cytometric analyses, distinguished the polymer systems with Cl/PAS/CLV containing 26% of grafting degree and 43% of ionic units or 46% of grafting degree and 18% of ionic units as the optimal systems.

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“…Although many kinds of research studies have been performed on the lubrication properties of PMPC brushes, the realization of superlubricity is usually obtained between two brush-modified surfaces, and it is difficult to achieve superlubricity with only one surface modified by PMPC brushes, which would benefit the surfaces that were difficult to modify by chemical graft. Besides, although the effects of types of salt on PMPC brushes have also been explored, the lubricating performance of polyzwitterionic brushes in the presence of multivalent cations has remained unclear. ,,− In this work, we performed the frictional force test with only one surface modified by PMPC brushes, finding that the frictional force was high in the initial stage for this asymmetric structure. However, the frictional force reduced gradually with an increase in the sliding, and finally, the superlubricity state was achieved after a running-in process.…”

Section: Introductionmentioning

confidence: 99%

Superlubricity Achieved with Zwitterionic Brushes in Diverse Conditions Induced by Shear Actions

Feng

Liu

et al. 2021

Macromolecules

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Polymer brushes are known to have excellent lubricity when grafted on surfaces in water. In this study, poly(2-(methacryloyloxy)-ethyl phosphorylcholine) (PMPC) has been successfully grafted on a silica wafer through a surface-initiated atom transfer radical polymerization (SI-ATRP) method. The microscale friction properties between a silica probe and PMPC brushes were studied by atomic force microscopy (AFM). The PMPC molecules are gradually transferred from the substrate to the silica probe induced by shear actions in the initial friction process, causing the frictional force to gradually reduce with increasing sliding distance. The robust superlubricity with a friction coefficient of 0.006 was finally achieved after enough PMPC molecules had transferred onto the probe, which was attributed to the formation of a uniform hydration layer after the running-in process. The effects of PMPC brush thickness and ion types on friction and normal forces were also examined. This work may help us develop various surface modifications for lubrication enhancement by shear actions.

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Specific anion effects on the hydration and tribological properties of zwitterionic phosphorylcholine-based brushes

Cited by 26 publications

References 63 publications

The role of entropy in wetting of polymer brushes

The role of entropy in wetting of polymer brushes

Biological In Vitro Evaluation of PIL Graft Conjugates: Cytotoxicity Characteristics

Superlubricity Achieved with Zwitterionic Brushes in Diverse Conditions Induced by Shear Actions

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