Specific allergen immunotherapy for the treatment of atopic eczema: a Cochrane systematic review

Abstract

We found no consistent evidence that SIT is effective for treating AE, but due to the low quality of evidence further research is needed to establish whether SIT has a role in AE treatment.

Allergen immunotherapy in people, dogs, cats and horses – differences, similarities and research needs

“…Since then, allergen immunotherapy has been evaluated in many scientific studies. According to systematic reviews and meta‐analyses, SCIT is helpful in alleviating symptoms and reducing medication in patients with allergic rhinoconjunctivitis and allergic asthma, whereas its benefits for atopic dermatitis (AD) are still unclear . However, some clinical trials and reports of AD patient experience have been highly encouraging .…”

Temperature‐controlled laminar airflow (TLA) device in the treatment of children with severe atopic eczema: Open‐label, proof‐of‐concept study

“…SCORAD was reduced from a median of 34.9 [interquartile range 28.75-45.15] at Baseline to 17.2 [12.95-32.3] at the final visit, and IGA improved significantly from 4 [3-4] to 2 [1-3]. We observed a significant improvement in .0] to 12 [8][9][10][11][12][13][14][15][16][17][18], P = .023) and DFI (P = .011), but not CDQLI or POEM. Compared to 6-month period prior to enrolment, there was a significant reduction at six months after the start of the intervention in potent topical corticosteroids (P = .033).…”

“…Compared to Visit 1, FDQLI at Visit 12 was significantly lower (16.0 [12.25-19.0] to 12 [8][9][10][11][12][13][14][15][16][17][18], P = .02), suggesting improvement, as did DFI (P = .01). Figure S3 shows data on medication use and healthcare utilization.…”

“…Sensitization rates to inhalant allergens among patients with AE are high, and there is evidence that aeroallergen exposure can trigger AE exacerbations . However, studies investigating the use of allergen avoidance and allergen‐specific immunotherapy in the treatment of AE have yielded mixed results, and these interventions are currently not recommended in the disease management . A recent meta‐analysis of seven studies of house dust mite (HDM) allergen avoidance highlighted the very low‐quality evidence currently available, with no studies to date investigating the effect of environmental control among patients with severe AE.…”

“…[8][9][10][11] However, studies investigating the use of allergen avoidance and allergen-specific immunotherapy in the treatment of AE have yielded mixed results, and these interventions are currently not recommended in the disease management. 12,13 A recent meta-analysis of seven studies of house dust mite (HDM) allergen avoidance highlighted the very low-quality evidence currently available, 12 with no studies to date investigating the effect of environmental control among patients with severe AE. We hypothesized that effective reduction in exposure to inhaled allergens and other environmental triggers remains a potentially effective intervention which may reduce disease severity amongst sensitized patients with severe AE.…”