Specific airway resistance in preschool children: why not panting after all?

Ioan, Iulia; Demoulin‐Alexikova, Silvia; Coutier, Laurianne; Bonabel, Claude; Kirkby, Jane; Nielsen, Kim G.; Tomalak, Waldemar; Thompson, Bruce; Robinson, Paul D.; Marchal, François

doi:10.1183/13993003.01302-2016

Cited by 3 publications

(3 citation statements)

References 13 publications

(27 reference statements)

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“…Nevertheless these figures are within those reported for sRaw in non-naïve adult subjects, i.e., 10% variability and 20% between day repeatability ( Peslin et al, 1987 ). Also, the estimated short term coefficient of variation for either sRa here is well within those reported for clinical measurements of sRaw – about 10% – in healthy or asthmatic children ( Bisgaard and Klug, 1995 ; Klug and Bisgaard, 1997 ; Coutier et al, 2015 ; Ioan et al, 2016 ). The between session repeatability was within 5% for all analog parameters, an important result in the context of between laboratory equipment comparison, while the between day variability in healthy adult subjects was reported to be respectively, about 6% for thoracic gas volume and 20% for sRaw ( Peslin et al, 1987 ).…”

Section: Discussionsupporting

confidence: 83%

A Calibration Device to Compare Body Plethysmographs Among Pediatric Lung Function Laboratories

et al. 2018

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Multi-center studies in specific airway resistance have shown significant inter laboratory variability. Comparison of plethysmographic equipment using a lung model easily transportable from one site to another should be of help to international normative studies. A resistor made of parallel capillary tubes – insuring adequate linearity within 1 L/sec – was connected to a glass bottle. Thermal time constants were measured while the bottle was empty and while stuffed with steel wool. In the latter, isothermal condition was estimated to occur only at very low frequency (around 0.01 Hz) and gas compression was polytropic up to 0.6 Hz. With the empty analog, adiabatic gas compression was estimated to occur at frequencies ≥0.2 Hz, and more accurate volume estimation was obtained. The empty analog volume and specific resistance measured in a body plethysmograph on different days indicated within 5% accuracy as well as intersession repeatability. It is concluded that a physical analog built out of simple material provides accurate measurements of specific resistance. The apparatus should be of help to compare plethysmographic equipments from different laboratories.

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Section: Discussionsupporting

confidence: 83%

A Calibration Device to Compare Body Plethysmographs Among Pediatric Lung Function Laboratories

et al. 2018

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“…47 Additionally, there is currently no published consensus on the best method to define abnormal LCI in preschool children. 22,25,48 Furthermore, although whole-body plethysmography and measurement of specific airway resistance (sRAW) are feasible in preschool children and need minimal cooperation, 49,50 whole-body plethysmography is only available in tertiary care pulmonary function laboratories and not feasible in most office practices. Therefore, we used spirometry, oscillometry, and MBW in this study as potentially feasible field tools to assess PFTs in preschool children.…”

Section: Discussionmentioning

confidence: 99%

Lung clearance index predicts persistence of preschool wheeze

Safavi

Dai

Breton

et al. 2021

Pediatric Allergy Immunology

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Background The lung clearance index (LCI) is a measure of pulmonary function. Variable feasibility (50‐>80%) in preschool children has been reported. There are limited studies exploring its relationship to respiratory symptoms and how it predicts persistent wheeze. We aimed to assess the association with respiratory symptoms in preschool‐aged children with LCI and determine its utility in predicting persistent wheeze. Methods LCI was measured in a subcohort of the CHILD Cohort Study at age 3 years using SF6 multiple breath washout test mass spectrometry. Respiratory symptom phenotypes at age 3 were derived from children's respiratory symptoms reported by their parents. Responses were used to categorize children into 4 symptom groups: recurrent wheeze (3RW), recurrent cough (3RC), infrequent symptoms (IS), and no current symptoms (NCS). At age 5 years, these children were seen by a specialist clinician and assessed for persistent wheeze (PW). Results At age 3 years, 69% (234/340) had feasible LCI. Excluding two children with missing data, 232 participants were categorized as follows: 33 (14%) 3RW; 28 (12%) 3RC; 17 (7%) IS; and 154 (66%) NCS. LCI z‐score at age 3 years was highest in children with 3RW compared to 3RC (mean (SD): 1.14 (1.56) vs. 0.09 (0.95), p < .01), IS (mean (SD): −0.14 (0.59), p < .01), and NCS (mean (SD): −0.08 (1.06), p < .01). LCI z‐score at age 3 was predictive of persistent wheeze at age 5 (PW) (AUROC: 0.87). Conclusions LCI at age 3 was strongly associated with recurrent wheeze at age 3, and predictive of its persistence to age 5.

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“…It has been suggested that a tidal breathing manoeuvre will increase the likelihood of a successful test in children. 26 We found that COPD patients were able to perform acceptable SR aw measurements, and volume of thoracic gas (VTG) measurements during occlusion, both in panting and tidal breathing manoeuvres. Although SR aw values were frequency dependent, lung volumes were not, as FRC was reported as the volume at the end of baseline tidal breathing, and not the volume during occlusion (ie VTG).…”

Section: Dovepressmentioning

confidence: 92%

Investigation of the Methodology of Specific Airway Resistance Measurements in COPD

Dean,

Singh

2023

COPD

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Introduction: Specific resistance (SR aw ) measurements in Chronic Obstructive Pulmonary Disease (COPD) patients may be performed by panting or tidal breathing. The aim of this study was to compare how breathing frequency affected SR aw in COPD and compare different tangent plotting methods. Methods: Fifteen COPD patients participated. Three protocols were performed: tidal 1 -spontaneous tidal breathing; tidal 2 -tidal breathing with a flow of ±1 L/sec; panting -60 breaths per min. Effective (SR eff ), total (SR tot ), ±0.5 L/s (SR 0.5 ), and mid (SR mid ) specific resistance were assessed. Results: The tidal breathing protocols provided similar results. Panting resulted in higher SR eff (p = 0.0002) and SR tot (p < 0.0001) versus tidal breathing, but not SR 0.5 or SR mid . Breathing frequency did not affect intra-test variance. SR eff and SR tot measurements were similar, and were higher than SR 0.5 , during tidal breathing (p = 0.0014 and p < 0.0001 respectively) and panting (p = 0.0179 and p < 0.0001 respectively). SR tot was higher than SR mid during tidal breathing (p < 0.0001) and panting (p < 0.0001). Intra-test variance of SR eff and SR tot were similar and showed the lowest percent coefficient of variation during both tidal breathing and panting. Conclusion: Panting and tidal breathing manoeuvres are not interchangeable in COPD patients. Panting widens the clubbing in the SR aw loop. SR 0.5 and SR mid may underestimate abnormal physiology in COPD. Plain Language Summary:The effort to breathe can be measured as specific airway resistance (SR aw ), which is a measure of the airflow that a person can achieve. SR aw is calculated from a plotted loop, but may be affected by the way that the test is performed and calculated. SR aw can be measured during panting or tidal breathing, and can be calculated using different methods of plotting the SR aw slope. In COPD patients, we found that panting SR aw is higher than during tidal breathing, and the calculation methods that use the extremities of the SR aw loop give higher values and have the lowest variability.

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Specific airway resistance in preschool children: why not panting after all?

Cited by 3 publications

References 13 publications

A Calibration Device to Compare Body Plethysmographs Among Pediatric Lung Function Laboratories

A Calibration Device to Compare Body Plethysmographs Among Pediatric Lung Function Laboratories

Lung clearance index predicts persistence of preschool wheeze

Investigation of the Methodology of Specific Airway Resistance Measurements in COPD

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