Specific [3H]γ-aminobutyric acid binding to vestibular membranes of the chick inner ear

Meza, Graciela; ́lez-Viveros, Ma. Teresa Gonza; Ruíz, Mariano

doi:10.1016/0006-8993(85)91628-2

Cited by 18 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Binding constants, calculated from the saturation curves, compared favourably with those reported for neural-tissue membranes, results that can be interpreted as reflecting the existence of a GABA receptor of the postsynaptic type (GABA A ) in a crude membrane preparation of the chick inner ear [38].…”

Section: The Criterion Of Mimicry and Pharmacological Antagonismsupporting

confidence: 56%

“…As one important criterion of the postsynaptic element, the presence of postsynaptic GABA receptors in the vertebrate labyrinth was investigated, measuring specific 3 H-GABA binding to labyrinthine membrane in the chick that was displaced by an excess of the unlabeled GABA and by bicuculline, both interactions being Na + -independent [38].…”

Section: The Criterion Of Mimicry and Pharmacological Antagonismmentioning

confidence: 99%

See 1 more Smart Citation

Modalities of GABA and Glutamate Neurotransmission in the Vertebrate Inner Ear Vestibule

Meza

2008

Neurochem Res

Self Cite

View full text Add to dashboard Cite

GABA and glutamate have been postulated as afferent neurotransmitters at the sensory periphery inner ear vestibule in vertebrates. GABA has fulfilled the main criteria to act as afferent neurotransmitter but may also be a putative efferent neurotransmitter, mainly due to cellular localization of its synthesizing enzyme glutamate decarboxylase derived from biochemical, immunocytochemical, in situ hybridization and molecular biological techniques, whereas glutamate afferent neurotransmission role is supported mainly by pharmacological evidences. GABA and Glu could also act as afferent co-neurotransmitters based upon immunocytochemical techniques. This multiplicity was not considered earlier and postulates a peripheral modulation of afferent information being sent to higher vestibular centers. In order to make a definitive cellular assignation to these putative neurotransmitters it is necessary to have evidences derived from immunocytochemical and pharmacological experiments in which both substances are tested simultaneously.

show abstract

Section: The Criterion Of Mimicry and Pharmacological Antagonismsupporting

confidence: 56%

Section: The Criterion Of Mimicry and Pharmacological Antagonismmentioning

confidence: 99%

Modalities of GABA and Glutamate Neurotransmission in the Vertebrate Inner Ear Vestibule

Meza

2008

Neurochem Res

Self Cite

View full text Add to dashboard Cite

show abstract

Ontogeny of 3H-muscimol binding to membranes of chick forebrain

Stewart

Bourne

1987

Exp Brain Res

View full text Add to dashboard Cite

A potent GABA agonist, 3H-muscimol, was used to investigate the development of GABA receptors in left and right hemispheres of chick forebrain from day 12 in ovo to day 21 post-hatch. Total specific 3H-muscimol binding (p mol mg-1 protein) increases rapidly in ovo, reaching a peak at around day one post-hatch and then showing a slow decline to approximately 50% of the maximal level at day 21 post-hatch. Despite the considerable evidence from previous studies of lateralization of avian brain function, no significant hemispheric differences were found in 3H-muscimol binding (either of p mol hemisphere-1 or p mol mg protein-1) at any of the developmental ages examined.

show abstract

GABA immunoreactivity of calyceal nerve endings in the vestibular system of the guinea pig

1990

View full text Add to dashboard Cite

Neurotransmitters involved in the vestibular system are largely uncharacterized. On the basis of results of earlier electrophysiological and immunohistochemical experiments, glutamate and gamma-amino-butyric acid (GABA) have been proposed in both mammalian and non-mammalian species as afferent transmitters between the sensory cell and the afferent dendrite. GABA is also suspected to act as an efferent neurotransmitter in the cochlea. We describe in this study the immunocytochemical localization of GABA within the vestibular end organs in the guinea pig. GABA immunoreactivity was found in the calyceal nerve endings surrounding type I hair cells of the vestibular epithelia. The most significant labelings were obtained in the crista ampullaris. Labeling was more difficult to observe in the utricular and saccular macula. These results contribute to the recent proposal that the calyx has a secretory function, and suggest that GABA may have a modulatory influence upon the type I hair cells.

show abstract

Specific [3H]γ-aminobutyric acid binding to vestibular membranes of the chick inner ear

Cited by 18 publications

References 26 publications

Modalities of GABA and Glutamate Neurotransmission in the Vertebrate Inner Ear Vestibule

Modalities of GABA and Glutamate Neurotransmission in the Vertebrate Inner Ear Vestibule

Ontogeny of 3H-muscimol binding to membranes of chick forebrain

GABA immunoreactivity of calyceal nerve endings in the vestibular system of the guinea pig

Contact Info

Product

Resources

About