“…CL PO data for rats ( CL PO,rat ; range, 0.300–27778 mL/min/kg), dogs ( CL PO,dog ; range, 0.150–1598 mL/min/kg), and humans ( CL PO,man ; range, 0.150–3767 mL/min/kg) after oral administration of 87 drugs were obtained from the literature 6–128. The CL PO data for other species (mice, rabbits, monkeys, baboons, or guinea pigs) were also obtained to apply allometric approaches.…”