Special section: Focus on anti-microbial photodynamic therapy (PDT)

Winckler, K.

doi:10.1016/j.jphotobiol.2006.09.005

Cited by 39 publications

(30 citation statements)

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“…The interaction between the PS excited states and the endogenous oxygen in the proximity of the target cells provides the cytotoxic effects through the production of in situ reactive oxygen species (ROS) (3). The main advantages of APDT are high target specificity (provided that the PS is localized in the microorganisms without major involvement of the surrounding tissues or cells and by the selection of a suitable illumination protocol [17]), with few undesired side effects (the drug is inactive in the dark and becomes active only when exposed to light) (21). A standard APDT protocol, in fact, includes incubation of the target cells or diseased tissue in the dark with the PS (which is intrinsically nontoxic), followed by a short illumination to generate ROS, which are responsible for irreversible oxidative damage to essential cellular constituents of the microorganisms to which the PS is bound.…”

mentioning

confidence: 99%

In Vitro Resistance Selection Studies of RLP068/Cl, a New Zn(II) Phthalocyanine Suitable for Antimicrobial Photodynamic Therapy

Giuliani

Martinelli

Cocchi

et al. 2010

Antimicrob Agents Chemother

185

136

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Resistance to antimicrobial agents is emerging in a wide variety of nosocomial and community-acquired pathogens. The development of alternative therapies against nosocomial infections caused by clinically relevant pathogens represents a major public health concern. RLP068/Cl is a novel Zn(II) phthalocyanine proposed as a photosensitizer suitable for antimicrobial photodynamic therapy (APDT) for localized infections. Its ability, following activation by light, to induce resistance in three major human pathogens after 20 daily passages was studied. Simultaneously for the same strains, the ability of daily sequential subcultures in subinhibitory concentrations of RLP068/Cl to develop resistant mutants without illumination was evaluated. We demonstrate that 20 consecutive APDT treatments with RLP068/Cl did not result in any resistant mutants and that, in dark conditions, only Staphylococcus aureus strains had increased MICs of RLP068/Cl. However, even in this case, the susceptibility of the mutated bacteria to APDT was not affected by their MIC increase.

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mentioning

confidence: 99%

In Vitro Resistance Selection Studies of RLP068/Cl, a New Zn(II) Phthalocyanine Suitable for Antimicrobial Photodynamic Therapy

Giuliani

Martinelli

Cocchi

et al. 2010

Antimicrob Agents Chemother

185

136

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“…The need for alternative efficient and affordable treatment of infections and illness has been imperative due to the widespread and increasing resistance of fungal, bacterial and viral pathogens to common antibiotics and therapies [19] . Photodynamic therapy has been used in recent decades and has been found useful in various diseases.…”

Section: Discussionmentioning

confidence: 99%

Effect of photo activated disinfection on osseointegration of immediate implants placed in infected sockets

Alghandour¹,

Elsharkawy²,

Elshalkamy³

et al. 2017

Int J Dentistry Res

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The technique of immediate implant placement was first described by Lazzara in 1989. This one-step surgical procedure reduces treatment time, improves esthetic out-comes, increases comfort during healing, and has proven to be a predictable strategy with a high success rate in absence of periapical lesions. The presence of active infection in the extraction site is considered one of the main contraindications to immediate implant insertion in the socket because of the increased possibility of infection spreading to peri-implant tissues during the healing period. Photodynamic therapy is based on the idea that nontoxic photosensitive agent, called photosensitizer activated by light with susceptible wavelength and produces singlet oxygen and free radicals, which are cytotoxic for the target cells. This technique has proven to reduce periapical infection and so provide more success rate for immediate implant in infected sockets.

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“…Besides the oncological field, this methodology can also be applied in the inactivation of pathogenic microorganisms (Almeida et al 2014, Alves et al 2011, Bonnett et al 2006, Carvalho et al 2007, Costa et al 2010, Mesquita et al 2014. One of the main benefits of the photodynamic approach on the inactivation of microorganisms is that it is improbable that mechanisms of resistance can be developed, due to the multi-target character of the photodynamic process (Costa et al 2011, Mesquita et al 2014, Tavares et al 2010, Winckler 2007.…”

Section: Introductionmentioning

confidence: 99%

An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy

Mesquita

Dias

Gamelas

et al. 2018

An. Acad. Bras. Ciênc.

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Photodynamic therapy (PDT) is a modality of cancer treatment in which tumor cells are destroyed by reactive oxygen species (ROS) produced by photosensitizers following its activation with visible or near infrared light. The PDT success is dependent on different factors namely on the efficiency of the photosensitizer deliver and targeting ability. In this review a special attention will be given to the role of some drug delivery systems to improve the efficiency of tetrapyrrolic photosensitizers to this type of treatment.

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Special section: Focus on anti-microbial photodynamic therapy (PDT)

Cited by 39 publications

References 0 publications

In Vitro Resistance Selection Studies of RLP068/Cl, a New Zn(II) Phthalocyanine Suitable for Antimicrobial Photodynamic Therapy

In Vitro Resistance Selection Studies of RLP068/Cl, a New Zn(II) Phthalocyanine Suitable for Antimicrobial Photodynamic Therapy

Effect of photo activated disinfection on osseointegration of immediate implants placed in infected sockets

An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy

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