An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy

Mesquita, Mariana Q.; Dias, Cristina J.; Gamelas, Sara R.D.; Fardilha, Margarida; Neves, Maria G. P. M. S.; Faustino, Maria A. F.

doi:10.1590/0001-3765201720170800

Cited by 96 publications

(82 citation statements)

References 177 publications

(101 reference statements)

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“…Considering that for an efficient PDT treatment, it is essential to minimize the formation of inactive aggregates in aqueous environment, the TZ-POR derivatives 7a-f were incorporated into PVP micelles. PVP is a water soluble and non-toxic polymer, widely used to modify the compound water solubility, the pharmacokinetics and pharmacological (including antitumor) activity of various biologically active compounds [53]. PVP has been successfully applied as carrier for chlorin e6 (Ce6) and a Ce6-PVP formulation called Photolon has been already approved for PDT [54,55].…”

Section: Incorporation Of β-Substituted Triazole-porphyrins 7a-f Intomentioning

confidence: 99%

Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives

et al. 2020

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Novel triazole-porphyrin derivatives (TZ-PORs) were synthesized through the Heck reaction and then incorporated into polyvinylpyrrolidone (PVP) micelles. After verifying that this incorporation did not compromise the photophysical and chemical features of TZ-PORs as photosensitizers, the phototoxicity of the formulations towards cancer cells was screened. Biological studies show high photodynamic activity of all PVP-TZ-POR formulations against a bladder cancer cell line with a particular highlight to PVP-TZ-POR 7e and 7f that are able to significantly reduce HT-1376 cell viability, while they had no effect on control ARPE-19 cells.

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Section: Incorporation Of β-Substituted Triazole-porphyrins 7a-f Intomentioning

confidence: 99%

Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives

et al. 2020

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“…GBMs, porphyrins and related compounds (as phthalocyanines, chlorins, azide-substituted porphyrinoids) have been individually explored (through different synthetic methods and functionalization routes) for different medical cancer treatments, as extensively reviewed elsewhere. [181][182][183][184][185][186][187][188][189][190][191][192][193] However, both systems individually present some limitations, such as the low solubility of GO or the aggregation tendency of porphyrins in physiological medium, due to the presence of salts and to the nonspecific binding of proteins..…”

Section: Applications Of Go/porphyrin Hybrids In Cancer Therapiesmentioning

confidence: 99%

Functionalization of Graphene Oxide with Porphyrins: Synthetic Routes and Biological Applications

2020

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Among the available carbon nanomaterials, graphene oxide (GO) has been widely studied because of the possibility of anchoring different chemical species for a large number of applications, including those requiring water‐compatible systems. This Review summarizes the state‐of‐the‐art of synthetic routes used to functionalize GO, such as those involving multiple covalent and non‐covalent bonds to organic molecules, functionalization with nanoparticles and doping. As a recent development in this field, special focus is given to the formation of nanocomposites comprising GO and porphyrins, and their characterization through spectroscopic techniques (such as UV‐Vis, fluorescence, Raman spectroscopy), among others. The potential of such hybrid systems in targeted biological applications is also discussed, namely for cancer therapies relying on photodynamic and photothermal therapies and for the inhibition of telomerase enzyme. Lastly, some promising alternative materials to GO are presented to overcome current challenges of GO‐based research and to inspire future research directions in this field.

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“…4). [33][34][35][36][37] Nanoparticles are widely classified as metal nanoparticles and semiconductor nanoparticles. In metals, the surface characteristics become dominant and offer unique property to nanoparticles.…”

Section: Potential Of Nanophotonics In Cancer Theranosticsmentioning

confidence: 99%

Cancer Theranostics: Bridging Conventional and Nano-photodynamic Therapy

Gananathan

Chakraborty

Karunasagar

2020

Journal of Health and Allied Sciences NU

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in).Cancer is of various kinds, so are the treatment modalities. Worldwide, cancer is the second leading cause of death, accounting for a whopping 9.6 million deaths in 2018. Globally, approximately one in six deaths is attributed to cancer. Photodynamic therapy (PDT) is a therapeutic strategy for the treatment of superficial lesions, warts, Barrett's esophagus, premalignant lesions, malignant tumors, and ophthalmic diseases. The literature on PDT is approximately one-third of that in radiation therapy, yet the clinical implementation of PDT in cancer is relatively less. Despite substantial research, the clinical application of photodynamic strategy in cancer therapy is still in its infancy with only a limited number of case studies reported so far. The limitations of the photosensitizer and the shallow depth of penetration of light source are the key technical impediments. However, the use of nanomedicine in PDT can overcome these obstacles. Thus, it is necessary to gain knowledge on how nanomaterials can be merged with PDT and how it can be utilized in cancer theranostics. In this article, the focus is to understand how PDT works and how it can be utilized in improving the sensitivity of the existing diagnostic and therapeutic techniques. The article also addresses the current challenges for PDT and the future prospects of this technique, particularly in the area of diagnosis and treatment of cancer. AbstractKeywords ► cancer ► photodynamic therapy ► nanoparticles ► theranostics

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An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy

Cited by 96 publications

References 177 publications

Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives

Synthesis, Characterization and Photodynamic Activity against Bladder Cancer Cells of Novel Triazole-Porphyrin Derivatives

Functionalization of Graphene Oxide with Porphyrins: Synthetic Routes and Biological Applications

Cancer Theranostics: Bridging Conventional and Nano-photodynamic Therapy

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