“Special research presentation” endothelin regulation of cyr61 in uterine leiomyomas

Wallace, Kedra; Chatman, Krystal; Spencer, Shauna‐Kay; Johnson, Venessia; LaMarca, Babbette

doi:10.1016/j.fertnstert.2014.07.365

Cited by 1 publication

(1 citation statement)

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“…The results indicated that the expression of CCNl/Cyr61 may not be regulated by the estrogen receptor in uterine fibroids. Fundamental research was conducted by Wallace et al ( 52 ) to determine if hypoxia induced CCNl/Cyr61 secretion through the Endothelin-A (ET A ) receptor in UL. However, the results identified that blockade of the ETA receptor demonstrated no significant influence on the increase of CCNl/Cyr61 expression under normoxic or hypoxic conditions and the secretion of CCNl/Cyr61 may not be regulated by the ETA receptor in UL.…”

Section: Ccn1/cyr61 and The Female Reproductive Systemmentioning

confidence: 99%

Biological functions and role of CCN1/Cyr61 in embryogenesis and tumorigenesis in the female reproductive system (Review)

Yang

Chen

2017

Mol Med Report

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Cysteine-rich angiogenic inducer 61 (CCN1/Cyr61) is a prompt response transcription product activated by growth factors. As a member of the CCN family, it mediates cell survival, proliferation, differentiation, migration, adhesion and synthesis of the extracellular matrix by binding directly to the integrins and heparin sulfate proteoglycans or activating multiple signaling transduction pathways. It has previously been demonstrated that CCN1/Cyr61 exhibits an important role in the female reproductive system during embryogenesis and tumorigenesis. However, the functions of CCN1/Cyr61 in the female reproductive system have not been systematically investigated, therefore, the primary aim of the present review is to introduce the role and function of CCN1/Cyr61 in the female reproductive system. The current review presents the molecular structure and biological function of CCN1/Cyr61 and provides detailed data on its expression pattern and contribution to the female reproductive system, including the role in embryogenesis and tumorigenesis.

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Section: Ccn1/cyr61 and The Female Reproductive Systemmentioning

confidence: 99%