Special Issue: Anti-Inflammatory Activity of Plant Polyphenols

Sangiovanni, Enrico; Dell’Agli, Mario

doi:10.3390/biomedicines8030064

Cited by 8 publications

(5 citation statements)

References 26 publications

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“…Immuno-stimulation induced by AFB1 increases the synthesis of inflammatory markers and free radicals, which lead to chronic inflammation and cancer [ 42 , 43 ]. Anti-inflammatory activities of plant bioactive compounds have been reported in acute and chronic inflammation in animal models [ 44 , 45 ], and recent data have shown that they can be used for counteracting the toxic effect of AFB1 [ 24 , 46 , 47 ]. Our previous results have shown that GSM addition into AFB1-contaminated diet induced the amelioration of liver injuries and decreased inflammation and oxidative stress in the liver of intoxicated piglets by decreasing the MAPKs and NF-κB signaling pathways overexpressed by the AFB1 diet [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Grape Seed Waste Counteracts Aflatoxin B1 Toxicity in Piglet Mesenteric Lymph Nodes

Marin

Bulgaru

Anghel

et al. 2020

Toxins

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Aflatoxin B1 (AFB1) is a mycotoxin that frequently contaminates cereals and cereal byproducts. This study investigates the effect of AFB1 on the mesenteric lymph nodes (MLNs) of piglets and evaluates if a diet containing grape seed meal (GSM) can counteract the negative effect of AFB1 on inflammation and oxidative stress. Twenty-four weaned piglets were fed the following diets: Control, AFB1 group (320 μg AFB1/kg feed), GSM group (8% GSM), and AFB1 + GSM group (8% GSM + 320 μg AFB1/kg feed) for 30 days. AFB1 has an important antioxidative effect by decreasing the activity of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) and total antioxidant status. As a result of the exposure to AFB1, an increase of MAP kinases, metalloproteinases, and cytokines, as effectors of an inflammatory response, were observed in the MLNs of intoxicated piglets. GSM induced a reduction of AFB1-induced oxidative stress by increasing the activity of GPx and SOD and by decreasing lipid peroxidation. GSM decreased the inflammatory markers increased by AFB1. These results represent an important and promising way to valorize this waste, which is rich in bioactive compounds, for decreasing AFB1 toxic effects in mesenteric lymph nodes.

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Section: Discussionmentioning

confidence: 99%

Grape Seed Waste Counteracts Aflatoxin B1 Toxicity in Piglet Mesenteric Lymph Nodes

Marin

Bulgaru

Anghel

et al. 2020

Toxins

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“…exhibit anti-inflammatory activity through different mechanisms, including the impairment of the nuclear factor-kB pathway, inhibition of C-reactive protein, and modulation of proinflammatory mediators. [36][37] The beneficial or harmful effects of polyphenols on pregnancy are contradictory. In this regard, a recent review shows that a high concentration of polyphenols in diet may negatively affect the development of the fetus and the offspring's health.…”

Section: Discussionmentioning

confidence: 99%

Correlation between salivary biomarkers and plaque-induced gingivitis exacerbated by pregnancy

Aragón-Martínez¹,

Loredo-Escobar²,

Bravo³

et al. 2022

J Oral Res

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Objetive: To evaluate the correlation between salivary biomarkers (the salivary antioxidant ability, salivary level of polyphenols, and other antioxidants) with plaque-induced gingivitis exacerbated by pregnancy in pregnant and nonpregnant women. Material and Methods: For this observational study, medical records, dental examinations, and analyses of saliva samples were carried out in pregnant and nonpregnant women. A p-value of <0.05 was considered significant. Results: The pregnant women (n =17) exhibited a lower antioxidant capacity (p-value=0.0041), higher levels of polyphenols, gingival index, bleeding on probing, and subjects consuming mineral-enriched products (p-value from <0.0001 to 0.0466), and unchanged levels of phosphotungstic acid reactive substances, proteins, oral hygienic habits, plaque index and probing depth (p-value from 0.0683 to 0.8358), in comparison with the nonpregnant women (n=9). Also, a positive correlation between the gingival index and salivary polyphenol content was observed (r-value = 0.4087, p-value = 0.0202). Conclusion: The salivary polyphenols correlate with plaque-induced gingivitis exacerbated by pregnancy, suggesting a deficiency of salivary antioxidant protection.

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“…As well as featuring oil-rich fish, healthy dietary patterns such as Mediterranean-style diets and a dietary pattern that corresponds to the Eatwell Guide in the UK tend to be plant-based, consisting of high amounts of fibre-rich foods providing a variety of fibre types (such as wholegrains and pulses), which are important for gut health (Lockyer & Stanner 2019;Lockyer & Spiro 2020). Healthy dietary patterns additionally contain plenty of fruit and vegetables, which also provide fibre alongside a range of micronutrients and plant-specific compounds such as polyphenols, which have been suggested to have immune regulatory and anti-inflammatory effects (Sangiovanni & Dell'Agli 2020). Though several mechanisms have been suggested for polyphenols, a key mechanism proposed is that these compounds interfere with the nuclear factor jB (NF-jB) pathway, which ordinarily promotes the expression of adhesion molecules, cytokines and other pro-inflammatory mediators (Yahfoufi et al 2018).…”

Section: Healthy Dietary Patternsmentioning

confidence: 99%

Effects of diets, foods and nutrients on immunity: Implications for COVID‐19?

Lockyer

2020

Nutrition Bulletin

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The COVID‐19 pandemic has sparked an increase in claims that particular food and drink products and nutritional supplements are able to ‘boost’ immunity. The immune system is highly complex, consisting of many different cell types and processes, and nutritional adequacy is undoubtedly required to support its function. Specific roles have been established for several micronutrients including vitamins A, B6, B12, C and D, copper, folate, iron, selenium and zinc, with documented impacts on particular aspects of immune function as a result of clinical deficiencies. Increased susceptibility to infections and poorer outcomes have been commonly observed in cases of undernutrition. However, high bodyweight, diabetes and ageing are also associated with immune dysfunction. The gut microbiota is intimately linked with the immune system and there is some evidence to suggest that food components that favourably modify its composition, such as pre‐ and probiotics, may be advantageous in immune modulation. Studies also indicate some benefits of specific supplements; for example, zinc and vitamin C supplements have been shown to reduce the duration of the common cold; probiotics have been suggested to reduce the duration and severity of acute infectious diarrhoea and prevent antibiotic‐associated diarrhoea; and anti‐inflammatory effects of long‐chain omega‐3 fatty acids have also been demonstrated. However, at present there are no authorised EU health claims for any of these effects. In the light of the recent media interest in the role of diet and lifestyle on the immune system following the COVID‐19 outbreak, this article will summarise why a healthy, balanced diet is key to supporting immune function with consideration given to the latest thinking in relation to COVID‐19.

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Special Issue: Anti-Inflammatory Activity of Plant Polyphenols

Abstract: Inflammation is considered the first physiological response of the human body to infection or injury, playing a critical role in both innate and adaptive immunity [...]

Cited by 8 publications

References 26 publications

Grape Seed Waste Counteracts Aflatoxin B1 Toxicity in Piglet Mesenteric Lymph Nodes

Grape Seed Waste Counteracts Aflatoxin B1 Toxicity in Piglet Mesenteric Lymph Nodes

Correlation between salivary biomarkers and plaque-induced gingivitis exacerbated by pregnancy

Effects of diets, foods and nutrients on immunity: Implications for COVID‐19?

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