Special Issue: 3D Printing for Biomedical Engineering

Chua, Chee Kai; Yeong, Wai Yee; An, Jia

doi:10.3390/ma10030243

Cited by 20 publications

(18 citation statements)

References 27 publications

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“…Given its prevalence, 3D printing may serve pivotal roles in times of disaster. Historically, 3D printing has led to the development of models, prostheses, surgical aids, implants, and scaffolds [59] . Modern technological advancements have expanded its applications to critical care equipment.…”

Section: Applicationsmentioning

confidence: 99%

Applications of PLA in modern medicine

DeStefano

Khan

Tabada

2020

Engineered Regeneration

278

197

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Polylactic acid (PLA) is a versatile biopolymer. PLA is synthesized with ease from abundant renewable resources and is biodegradable. PLA has shown promise as a biomaterial in a plethora of healthcare applications such as tissue engineering or regenerative medicine, cardiovascular implants, dental niches, drug carriers, orthopedic interventions, cancer therapy, skin and tendon healing, and lastly medical tools / equipment. PLA has demonstrated instrumental importance as a three-dimensionally (3D) printable biopolymer, which has further been bolstered by its role during the Coronavirus Disease of 2019 (Covid-19) global pandemic. As an abundant filament, PLA has created desperately needed personal protective equipment (PPE) and ventilator modifications. As polymer chemistry continues to advance, so too will the applications and continued efficacy of PLA-based modalities.

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Section: Applicationsmentioning

confidence: 99%

Applications of PLA in modern medicine

DeStefano

Khan

Tabada

2020

Engineered Regeneration

278

197

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“…These technologies have allowed progress toward the custom 3D construction of both soft and hard tissues including skin, heart, kidney, and bone [1,2]. Bioprinting of high modulus materials (> 1 MPa range) for hard tissues, such as bone [3], has already been successfully demonstrated on a clinical scale for a wide range of polymeric materials (e.g., polyurethane, polycaprolactone, and block copolymers such as PEOT/PBT [4,5]) and printing techniques (e.g., 3D plotting [6] and fused deposition modelling [7]). However, the bioprinting of biological constructs for softer tissues with complex architecture remains limited.…”

Section: Introductionmentioning

confidence: 99%

“…Bioprinting of cell-laden hydrogels (bioinks) is attractive for the construction of complex soft tissue architectures, allowing for the creation of constructs with highly defined placement of both material composition and cells [5,11]. However, printing with live cells comes with a unique set of challenges for the hydrogel system used.…”

Section: Introductionmentioning

confidence: 99%

Viscoelastic Oxidized Alginates with Reversible Imine Type Crosslinks: Self-Healing, Injectable, and Bioprintable Hydrogels

Hafeez

Ooi

Morgan

et al. 2018

Gels

106

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Bioprinting techniques allow for the recreation of 3D tissue-like structures. By deposition of hydrogels combined with cells (bioinks) in a spatially controlled way, one can create complex and multiscale structures. Despite this promise, the ability to deposit customizable cell-laden structures for soft tissues is still limited. Traditionally, bioprinting relies on hydrogels comprised of covalent or mostly static crosslinks. Yet, soft tissues and the extracellular matrix (ECM) possess viscoelastic properties, which can be more appropriately mimicked with hydrogels containing reversible crosslinks. In this study, we have investigated aldehyde containing oxidized alginate (ox-alg), combined with different cross-linkers, to develop a small library of viscoelastic, self-healing, and bioprintable hydrogels. By using distinctly different imine-type dynamic covalent chemistries (DCvC), (oxime, semicarbazone, and hydrazone), rational tuning of rheological and mechanical properties was possible. While all materials showed biocompatibility, we observed that the nature of imine type crosslink had a marked influence on hydrogel stiffness, viscoelasticity, self-healing, cell morphology, and printability. The semicarbazone and hydrazone crosslinks were found to be viscoelastic, self-healing, and printable—without the need for additional Ca2+ crosslinking—while also promoting the adhesion and spreading of fibroblasts. In contrast, the oxime cross-linked gels were found to be mostly elastic and showed neither self-healing, suitable printability, nor fibroblast spreading. The semicarbazone and hydrazone gels hold great potential as dynamic 3D cell culture systems, for therapeutics and cell delivery, and a newer generation of smart bioinks.

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“…Additive manufacturing (AM) has received much attention for the manufacture of highly interconnected porous scaffolds with customized shapes to fit anatomical defects . Selective laser sintering (SLS) is a promising AM technique that can fabricate scaffolds using various biomaterials and their composites.…”

Section: Introductionmentioning

confidence: 99%

Akermanite reinforced PHBV scaffolds manufactured using selective laser sintering

Diermann

Dargusch

et al. 2019

J Biomed Mater Res

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Scaffold assisted tissue engineering presents a promising approach to repair diseased and fractured bone. For successful bone repair, scaffolds need to be made of biomaterials that degrade with time and promote osteogenesis. Compared to the commonly used ß‐tricalcium phosphate scaffolds, Akermanite (AKM) scaffolds were found to degrade faster and promote more osteogenesis. The objective of this study is to synthesize AKM micro and nanoparticle reinforced poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate; PHBV) composite scaffolds using selective laser sintering (SLS). The synthesized composite scaffolds had an interconnected porous microstructure (61–64% relative porosity), large specific surface areas (31.1–64.2 mm−1) and pore sizes ranging from 303 to 366 and 279 to 357 μm in the normal and lateral direction, respectively, which are suitable for bone tissue repair. The observed hydrophilic nature of the scaffolds and the swift water uptake was due to the introduction of numerous carboxylic acid groups on the scaffold surface after SLS, circumventing the need for postprocessing. For the composite scaffolds, large amounts of AKM particles were exposed on the skeleton surface, which is a requirement for cell attachment. In addition, the particles embedded inside the skeleton helped to significantly reinforce the scaffold structure. The compressive strength and modulus of the composite scaffolds were up to 7.4 and 103 MPa, respectively, which are 149 and 197% of that of the pure PHBV scaffolds. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2596–2610, 2019.

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Special Issue: 3D Printing for Biomedical Engineering

Cited by 20 publications

References 27 publications

Applications of PLA in modern medicine

Applications of PLA in modern medicine

Viscoelastic Oxidized Alginates with Reversible Imine Type Crosslinks: Self-Healing, Injectable, and Bioprintable Hydrogels

Akermanite reinforced PHBV scaffolds manufactured using selective laser sintering

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