A hybrid nanofibrous
mat consisting of polyurethane, dextran, and
10 wt % of biopigment (i.e., pyocyanin) was facilely fabricated using
a direct-conventional electrospinning method. The field emission scanning
electron microscopy showed the bead-free fibers with a twisted morphology
for the pyocyanin-loaded mat. The addition of pyocyanin enables the
unprecedented approach to tailor the hydrophilicity of hybrid mat,
as verified from the water contact measurement. Thermomechanical stabilities
of electrospun mats were investigated in terms of thermogravimetric
analysis, differential scanning calorimetry, and dynamic mechanical
analysis. The bacterial inhibition test revealed that the antibacterial
activity of electrospun mat containing pyocyanin was 98.54 and 90.2%
toward Escherichia coli and Staphylococcus aureus, respectively. By the combined
efforts of rapid release of pyocyanin and oxidative stress, the PU–dextran–pyocyanin
(PUDP) electrospun mat significantly declined the viable cell number
that disrupts the cell morphology. Hence, the proposed PUDP electrospun
mat must meet the requirements of efficient antimicrobial material
in various applications such as disinfectant wiping, food packaging,
and textile industries.