Spatio-temporal dynamics in the origin of genetic information

Kim, Pan-Jun; Jeong, Hawoong

doi:10.1016/j.physd.2005.03.004

Cited by 20 publications

(23 citation statements)

References 21 publications

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“…The spatially explicit ( cellular automaton ) implementation of the hypercycle model would be resistant to such selfish parasites, but not to shortcuts [ 21 ]. Its behaviour becomes complicated if the catalytic aid that replicators supply to each other are different [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Spatial aspects of prebiotic replicator coexistence and community stability in a surface-bound RNA world model

Könnyű

Czárán

2013

BMC Evol Biol

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BackgroundThe coexistence of macromolecular replicators and thus the stability of presumed prebiotic replicator communities have been shown to critically depend on spatially constrained catalytic cooperation among RNA-like modular replicators. The necessary spatial constraints might have been supplied by mineral surfaces initially, preceding the more effective compartmentalization in membrane vesicles which must have been a later development of chemical evolution.ResultsUsing our surface-bound RNA world model – the Metabolic Replicator Model (MRM) platform – we show that the mobilities on the mineral substrate surface of both the macromolecular replicators and the small molecules of metabolites they produce catalytically are the key factors determining the stable persistence of an evolvable metabolic replicator community.ConclusionThe effects of replicator mobility and metabolite diffusion on different aspects of replicator coexistence in MRM are determined, including the maximum attainable size of the metabolic replicator system and its resistance to the invasion of parasitic replicators. We suggest a chemically plausible hypothetical scenario for the evolution of the first protocell starting from the surface-bound MRM system.

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Section: Introductionmentioning

confidence: 99%

Spatial aspects of prebiotic replicator coexistence and community stability in a surface-bound RNA world model

Könnyű

Czárán

2013

BMC Evol Biol

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“…This system is capable of maintaining its diversity, but its evolvability is very limited [15], and it is unstable in both the ecological [16] and the evolutionary [17,18] sense. The spatial version of the hypercycle [19] does not perform much better either [20][21][22].…”

Section: Prebiotic Evolution I: Self-replicating Macromoleculesmentioning

confidence: 92%

Diversity, stability, and evolvability in models of early evolution

Scheuring

Szilágyi

2019

Current Opinion in Systems Biology

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Based on the RNA world hypothesis we outline a possible evolutionary route from infrabiological systems to early protocells. To assess the scientific merits of the different models of prebiotic evolution and to suggest directions for future research we investigate the diversity maintaining ability, evolutionary/ecological stability and evolvability criteria of existing RNA world model systems for the origin of life. We conclude that neither of the studied systems satisfies all of the above criteria, although some of them are more convincing than the others. Furthermore, we found that the most conspicuous features of the proposed prebiotic evolutionary scenarios are their increasing spatial inhomogeneity along with increasing plasticity, evolvability and functional diversity. All of these characteristics change abruptly with the emergence of the protocells.

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“…Spatial arrangement and compartmentalization [ 27 ] seems to solve the problem of a fast replicating parasite. Shortcut mutants, however, still outcompete longer sequences [ 85 ]. The short cycles that cannot form spirals are at a selective disadvantage compared to ones that can form spirals and thus exclude parasites.…”

Section: Models Of Prebiotic Systemsmentioning

confidence: 99%

Ecology and Evolution in the RNA World Dynamics and Stability of Prebiotic Replicator Systems

Szilágyi

Zachar

Scheuring

et al. 2017

Life

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As of today, the most credible scientific paradigm pertaining to the origin of life on Earth is undoubtedly the RNA World scenario. It is built on the assumption that catalytically active replicators (most probably RNA-like macromolecules) may have been responsible for booting up life almost four billion years ago. The many different incarnations of nucleotide sequence (string) replicator models proposed recently are all attempts to explain on this basis how the genetic information transfer and the functional diversity of prebiotic replicator systems may have emerged, persisted and evolved into the first living cell. We have postulated three necessary conditions for an RNA World model system to be a dynamically feasible representation of prebiotic chemical evolution: (1) it must maintain and transfer a sufficient diversity of information reliably and indefinitely, (2) it must be ecologically stable and (3) it must be evolutionarily stable. In this review, we discuss the best-known prebiotic scenarios and the corresponding models of string-replicator dynamics and assess them against these criteria. We suggest that the most popular of prebiotic replicator systems, the hypercycle, is probably the worst performer in almost all of these respects, whereas a few other model concepts (parabolic replicator, open chaotic flows, stochastic corrector, metabolically coupled replicator system) are promising candidates for development into coherent models that may become experimentally accessible in the future.

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Spatio-temporal dynamics in the origin of genetic information

Cited by 20 publications

References 21 publications

Spatial aspects of prebiotic replicator coexistence and community stability in a surface-bound RNA world model

Spatial aspects of prebiotic replicator coexistence and community stability in a surface-bound RNA world model

Diversity, stability, and evolvability in models of early evolution

Ecology and Evolution in the RNA World Dynamics and Stability of Prebiotic Replicator Systems

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