Spatial Tuning in Nociceptive Processing Is Driven by Attention

Adamczyk, Wacław M.; Katra, Michal; Szikszay, Tibor M.; Peugh, James; King, Christopher D.; Luedtke, Kerstin; Rc, Coghill

doi:10.1016/j.jpain.2023.03.005

Cited by 3 publications

(1 citation statement)

References 45 publications

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“… 17 In this line, an alternative mechanism explaining the relationship between expanded pain distribution and the increased risk of long-term sick leave may be the spatial summation of pain. This summation involves the heightened perception of pain intensity when the source of nociception affects a larger body area 1 , 51 or there are more body sites affected by nociception. 2 This central mechanism would explain that the increased risk of long-term sick leave in workers with, for example, 2 nearby nonserious musculoskeletal disorders and an expanded area of pain, is primarily because of pain intensity rather than the extent or the number of painful areas.…”

Section: Discussionmentioning

confidence: 99%

Does the distribution of musculoskeletal pain shape the fate of long-term sick leave? A prospective cohort study with register follow-up

Doménech-García,

Skovlund,

Bellosta-López

et al. 2024

Pain

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Although multisite pain can markedly reduce work ability, the relevance of the bodily pain distribution as a predictor of long-term sick leave is still unknown. This study aimed to investigate the association between musculoskeletal pain distributions and long-term sick leave in the general working population of Denmark and included 66,177 currently employed wage earners without long-term sick leave during the prior 52 weeks. Participants reported whether they had pain in the lower extremity (hips/knees), upper extremity (neck/shoulders), or the low back. The analysis controlled for age, sex, year of survey reply, educational level, occupational group, psychosocial work factors, body max index, smoking, leisure-time physical activity, and mental health confounders. The results demonstrated that the risk of long-term sick leave increased with the number of pain sites. Compared with no pain, localized pain in any body region increased the risk/hazard by 25% to 29% (HR [95% CI]: 1.29 [1.07-1.54] for pain only in the low back), whereas pain in 2 regions increased the risk by 39% to 44% (HR [95% CI]: 1.41 [1.18-1.69] for pain in the low back + hips/knees). Workers reporting pain in all 3 regions experienced a 72% increased risk (HR [95% CI]: 1.72 [1.55-1.91]). Thus, the number of pain regions seems to matter more than the exact pain location. The spatial extension of musculoskeletal pain in workers functions as a gradient system, where pain spread throughout the body is an independent indicator of the high risk of long-term sick leave.

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Section: Discussionmentioning

confidence: 99%

Does the distribution of musculoskeletal pain shape the fate of long-term sick leave? A prospective cohort study with register follow-up

Doménech-García,

Skovlund,

Bellosta-López

et al. 2024

Pain

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Spatial summation of pain is associated with pain expectations: Results from a home-based paradigm

Nastaj

Skalski

Budzisz

et al. 2022

Preprint

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The ongoing COVID-19 pandemic has led to many restrictions affecting the research conduct. The purpose of this study was to reproduce the previously observed spatial summation of pain effect (SSp) using non-laboratory procedures and commercial equipment. An additional aim was to measure the association between expectation and SSp for the first time. The Cold Pressor Task (CPT) was used to induce SSp. Healthy participants (N=68) immersed their non-dominant hands (divided into 5 segments) into cold water (Cold Pressor Task). Two conditions were used 1) gradual hand immersion (ascending condition) and 2) gradual hand withdrawal (descending condition). Pain intensity was measured on a Visual Analogue Scale (VAS). The influence of psychological factors, such as the volunteer's expectation of pain intensity, on the actual perception of pain were also measured on a VAS. Results showed significant SSp (p < 0.001), reproduced with non-laboratory equipment in a home-based set-up. Furthermore, two novel findings were observed: i) spatial summation increased with the increase in exposure to the noxious stimulus (p < 0.001), ii) there was a significant correlation between expectation and perceived pain, indicating that pain expectations can contribute to SSp. Results showed that SSp is shaped by a mixture of excitatory and inhibitory mechanisms and is influenced by the sensitization of the nociceptive system. Moreover, spatial summation is influenced by expectation. This study proposes a new feasible way to induce SSp using a home-based set-up using the CPT during COVID-19.

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Pain From a Distance: Can Third-Person Self-Talk Mitigate Pain Sensitivity and Pain Related Distress During Experimentally Induced Pain?

Gunnarsson,

Agerström

2024

Psychol Rep

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Pain is self-immersive, leading to a narrow, egocentric focus on the self in the here and now. Preliminary evidence suggests that distancing oneself from the pain can reduce experimentally induced pain. The primary aim of this experimental study was to examine whether a hitherto unexplored, simple self-distancing strategy – “third-person self-talk” – has an analgesic effect on physiological and psychological pain variables. Participants ( N = 292) were randomly assigned to one of four conditions (third-person self-talk, first-person self-talk, and two control conditions). Pain was induced with a cold pressor apparatus and pain tolerance, pain intensity, negative affect and blood pressure were measured for each group. While in pain, participants engaged in strategic self-talk aided by cue-cards. Data were analyzed with univariate planned comparisons. Few significant differences emerged for the third-person self-talk versus the other conditions. It is concluded that third-person self-talk does not seem to have a meaningful effect on physiological and psychological pain variables, although a small effect size could not be ruled out. Practical implications are discussed. The study was registered at ClinicalTrials.gov with the ClinicalTrials.gov ID NCT05511857.

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Spatial Tuning in Nociceptive Processing Is Driven by Attention

Cited by 3 publications

References 45 publications

Does the distribution of musculoskeletal pain shape the fate of long-term sick leave? A prospective cohort study with register follow-up

Does the distribution of musculoskeletal pain shape the fate of long-term sick leave? A prospective cohort study with register follow-up

Spatial summation of pain is associated with pain expectations: Results from a home-based paradigm

Pain From a Distance: Can Third-Person Self-Talk Mitigate Pain Sensitivity and Pain Related Distress During Experimentally Induced Pain?

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