Spatial Normalization of Brain Images with Focal Lesions Using Cost Function Masking

Brett, Matthew; Leff, Alexander; Rorden, Chris; Ashburner, John

doi:10.1006/nimg.2001.0845

Cited by 825 publications

(613 citation statements)

References 16 publications

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“…The DCT may be insufficient to model large focal warping to normalize enlarged ventricles from obstructive hydrocephalus associated with the tumors, and the SSD similarity measure could be biased by surgical cavities. Lesion masking improves DCT-derived spatial normalization (Brett et al, 2001); however, we have found this approach to be inadequate for the post-operative patient group.…”

Section: Introductionmentioning

confidence: 76%

Brain structural abnormalities in survivors of pediatric posterior fossa brain tumors: A voxel-based morphometry study using free-form deformation

et al. 2008

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Voxel-based morphometry was used to compare brain structure morphology of survivors of posterior fossa brain tumor (PFBT) with that of normal sibling controls to investigate disease-or cancer treatment-induced changes. Two different spatial normalization approaches that are available in public domain software (free-form deformation (FFD) and discrete cosine transform (DCT)) were compared for accuracy of normalization in the PFBT patients. Anatomical landmark matching demonstrated that spatial normalization was more accurate with FFD than with DCT. Voxel-based morphometry of the FFD-normalized magnetic resonance images from PFBT survivors and sibling controls detected reduced gray matter density in the thalamus and entorhinal cortex and reduced white matter density in the internal capsule, hypothalamus, corpus callosum, and cuneus of the occipital lobe in the PFBT survivors. Identification of these morphologic lesions may help localize the neural substrates of disease-or therapy-induced cognitive deficits in survivors of childhood cancer.

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Section: Introductionmentioning

confidence: 76%

Brain structural abnormalities in survivors of pediatric posterior fossa brain tumors: A voxel-based morphometry study using free-form deformation

et al. 2008

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“…T1 images from FIS patients and controls were segmented, and each lesion mask was used for cost-function masking for normalization to the MNI template. This procedure prevents lesions from biasing the transformations applied [61].…”

Section: (Iii) Lesion Mapping Analysismentioning

confidence: 99%

Feeling, learning from and being aware of inner states: interoceptive dimensions in neurodegeneration and stroke

García‐Cordero

Sedeño

Fuente

et al. 2016

Phil. Trans. R. Soc. B

135

259

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“…Lesions were traced onto each structural scan using MRIcro v1.34 (Rorden & Brett, 2000) to create a 3D lesion volume, and normalised to the SPM 96 (Statistical Parametric Mapping; Wellcome Department of Cognitive Neurology, London, UK) average T1 structural scan from 152 healthy subjects, using cost function masking (Brett, Leff, Rorden, & Ashburner, 2001) to exclude the lesion from the calculation of normalisation parameters. Lesion overlaps are displayed in Fig.…”

Section: Lesion Characteristicsmentioning

confidence: 99%

The role of the orbitofrontal cortex in human discrimination learning

et al. 2008

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Several lines of evidence implicate the prefrontal cortex in learning but there is little evidence from studies of human lesion patients to demonstrate the critical role of this structure. To this end, we tested patients with lesions of the frontal lobe (n = 36) and healthy controls (n = 35) on two learning tasks: the weather prediction task (WPT), and an eight-pair concurrent visual discrimination task ('Choose'). Performance of both tasks was previously shown to be disrupted in patients with Parkinson's disease; the Choose deficit was only present when patients were medicated. Patients with damage to the orbitofrontal cortex (OFC) were significantly impaired on Choose, compared to both healthy controls and non-OFC lesion patients. The OFC lesion patients showed a mild deficit on the first 50 trials of the WPT, compared to the control subjects but not non-OFC lesion patients. The selective deficit in the OFC patients on Choose performance could not be attributed to the larger lesion size in this group, and the deficit was not correlated with the volume of damage to adjacent prefrontal subregions (e.g. anterior cingulate cortex). These data support the notion that the OFC play a role in normal discrimination learning, and suggest qualitative similarities in learning performance of patients with OFC damage and medicated PD patients.

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Spatial Normalization of Brain Images with Focal Lesions Using Cost Function Masking

Cited by 825 publications

References 16 publications

Brain structural abnormalities in survivors of pediatric posterior fossa brain tumors: A voxel-based morphometry study using free-form deformation

Brain structural abnormalities in survivors of pediatric posterior fossa brain tumors: A voxel-based morphometry study using free-form deformation

Feeling, learning from and being aware of inner states: interoceptive dimensions in neurodegeneration and stroke

The role of the orbitofrontal cortex in human discrimination learning

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