19Keywords: diffusion MRI, probabilistic tractography, fractional anisotropy, saccade target 20 selection, visual extinction, endothelin-1, nonhuman primates 21Recently, we reported the longitudinal changes in resting-state functional connectivity 59 (rsFC) within the frontoparietal network after a unilateral caudal PFC lesion in macaque 60 monkeys (Adam et al., 2020). We showed that recovery of contralesional saccade choice 61 deficits correlated with increasing rsFC between the contralesional PFC and ipsilesional PPC. 62Since network-wide rsFC has been shown to reflect properties of the underlying structural 63 3 connections (Dijkhuizen et al., 2012;Greicius et al., 2009;Hagmann et al., 2008; Shen et al., 64 2015), here we expand on our previous study to examine the lesion-induced structural changes 65 of white matter pathways connecting the bilateral frontoparietal network, including bilateral 66 superior longitudinal fasciculus (SLF) and transcallosal fibers connecting bilateral PFC and 67 bilateral PPC. The SLF is long-range association pathway that connects frontoparietal areas 68 within hemisphere (Petrides and Pandya, 1984; Schmahmann et al., 2007; Thiebaut de 69 Schotten et al., 2012). Between hemispheres, the caudal PFC and PPC are connected to their 70 respective contralateral homologs via transcallosal fibers which cross at the genu or isthmus of 71 the corpus callosum, respectively (Barbas and Pandya, 1984;. It has not yet 72 been explored whether recovery of contralesional target selection after a focal lesion is 73 associated with changes in related white matter fibers. Moreover, the behavioural relevance of 74 structural alterations in remote fiber tracts before and after focal damage have been 75 understudied and are not well understood. 76In the present study, we examined the microstructural changes of frontoparietal white 77 matter tracts in those four macaque monkeys using high spatial and high angular resolution 78 diffusion-weighted MR imaging (DWI) acquired in vivo at 7T. DWI data were obtained at two 79 time points: before the unilateral PFC lesion and at a late post-lesion stage (week 8 or 16 post-80 lesion) when contralesional saccade choice deficits had largely recovered. Probabilistic fiber 81 tractography was used to reconstruct four fiber tracts of interest: contralesional and ipsilesional 82 SLF and transcallosal PFC and PPC tracts. Tract-specific diffusion parameters, including 83 fractional anisotropy (FA) and mean, axial, and radial diffusivity, were then calculated for each 84 tract and compared over time. We speculated that the remote fiber tracts (i.e., contralesional 85 SLF and transcallosal PPC) may have mediated the increased rsFC between contralesional 86 PFC and ipsilesional PPC that was found in our previous study (Adam et al., 2020), since those 87 tracts provide an undamaged pathway which indirectly links the cortical regions together. On the 88 other hand, ipsilesional SLF and transcallosal PFC fibers were likely damaged by 89 4 anterograde/retrograde degenerati...