Spatial focusing of magnetic particle hyperthermia

Myrovali, Eirini; Maniotis, Nikos; Samaras, Theodoros; Angelakeris, M.

doi:10.1039/c9na00667b

Cited by 34 publications

(36 citation statements)

References 59 publications

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“…The size, size distribution, and shape of a particular NM have a clear impact on its magnetic properties [ 31 ]. These parameters should ideally be optimized [ 32 ] so as to exhibit the highest heating power under a selected AMF frequency [ 33 , 34 , 35 ], while displaying minimal toxicity if not subjected to an external magnetic field. This optimization also minimizes the need to revise extrinsic parameters, such as the NM concentration or the AMF power.…”

Section: Main Parameters Influencing the Outcome Of A Preclinical mentioning

confidence: 99%

Magnetic Hyperthermia for Cancer Treatment: Main Parameters Affecting the Outcome of In Vitro and In Vivo Studies

2020

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Magnetic hyperthermia (MHT) is being investigated as a cancer treatment since the 1950s. Recent advancements in the field of nanotechnology have resulted in a notable increase in the number of MHT studies. Most of these studies explore MHT as a stand-alone treatment or as an adjuvant therapy in a preclinical context. However, despite all the scientific effort, only a minority of the MHT-devoted nanomaterials and approaches made it to clinical context. The outcome of an MHT experiment is largely influenced by a number of variables that should be considered when setting up new MHT studies. This review highlights and discusses the main parameters affecting the outcome of preclinical MHT, aiming to provide adequate assistance in the design of new, more efficient MHT studies.

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Section: Main Parameters Influencing the Outcome Of A Preclinical mentioning

confidence: 99%

Magnetic Hyperthermia for Cancer Treatment: Main Parameters Affecting the Outcome of In Vitro and In Vivo Studies

2020

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“…To address this important technical challenge, several research groups have demonstrated experimentally that the MPI gradient field can localize MFH heating [21,22,[61][62][63][64]. Despite using a 300 kHz magnetic field, we and others have demonstrated localized heating to millimeter-scale resolution.…”

Section: Fundamentals Of Gradient-based Localizationmentioning

confidence: 99%

Combining magnetic particle imaging and magnetic fluid hyperthermia for localized and image-guided treatment

Rivera‐Rodriguez

Tay

et al. 2020

International Journal of Hyperthermia

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“…Encapsulin systems that biomineralize iron naturally provide an efficient means of generating magnetic nanoparticles, with promising applications in magnetic hyperthermia therapy (MHT) [87]. Clinical trials of MHT have been approved for different types of cancer using superparamagnetic iron oxide nanoparticles [126]. The EncMx system was used to generate magnetic nanoparticles, which are monodisperse, resistant to extreme pH and protease digestion, and stable when exposed to blood and serum.…”

Section: Encapsulin-based Metallic Nanoparticlesmentioning

confidence: 99%

Nanotechnological Applications Based on Bacterial Encapsulins

et al. 2021

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Encapsulins are proteinaceous nanocontainers, constructed by a single species of shell protein that self-assemble into 20–40 nm icosahedral particles. Encapsulins are structurally similar to the capsids of viruses of the HK97-like lineage, to which they are evolutionarily related. Nearly all these nanocontainers encase a single oligomeric protein that defines the physiological role of the complex, although a few encapsulate several activities within a single particle. Encapsulins are abundant in bacteria and archaea, in which they participate in regulation of oxidative stress, detoxification, and homeostasis of key chemical elements. These nanocontainers are physically robust, contain numerous pores that permit metabolite flux through the shell, and are very tolerant of genetic manipulation. There are natural mechanisms for efficient functionalization of the outer and inner shell surfaces, and for the in vivo and in vitro internalization of heterologous proteins. These characteristics render encapsulin an excellent platform for the development of biotechnological applications. Here we provide an overview of current knowledge of encapsulin systems, summarize the remarkable toolbox developed by researchers in this field, and discuss recent advances in the biomedical and bioengineering applications of encapsulins.

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Spatial focusing of magnetic particle hyperthermia

Abstract: Magnetic particle hyperthermia is a promising cancer therapy, but a typical constraint of its applicability is localizing heat solely to malignant regions sparing healthy surrounding tissues.

Cited by 34 publications

References 59 publications

Magnetic Hyperthermia for Cancer Treatment: Main Parameters Affecting the Outcome of In Vitro and In Vivo Studies

Magnetic Hyperthermia for Cancer Treatment: Main Parameters Affecting the Outcome of In Vitro and In Vivo Studies

Combining magnetic particle imaging and magnetic fluid hyperthermia for localized and image-guided treatment

Nanotechnological Applications Based on Bacterial Encapsulins

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