Combining magnetic particle imaging and magnetic fluid hyperthermia for localized and image-guided treatment

Lu, Yao; Rivera‐Rodriguez, Angelie; Tay, Zhi Wei; Hensley, Daniel; Fung, K. L. Barry; Colson, Caylin; Saayujya, Chinmoy; Huynh, Quincy; Kabuli, Leyla; Fellows, Benjamin D.; Chandrasekharan, Prashant; Rinaldi, Carlos; Conolly, Steven M.

doi:10.1080/02656736.2020.1853252

Cited by 49 publications

(56 citation statements)

References 105 publications

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“…Magnetic Particle Imaging provides key benefits for MHT such as image-guidance ( Figure 1 f), quantitation of magnetic material on-site, which is essential for MHT thermal dose planning, and also the ability to select which magnetic nanoparticles to heat with pinpoint precision as low as a few millimeters [ 15 , 108 , 109 , 110 ]. This precision capability is a novel benefit in the field of MHT for cancer therapy.…”

Section: Magnetic Methods For Cancer Therapy In Context Of Magnetic Particle Imagingmentioning

confidence: 99%

Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Tay

Chandrasekharan

Fellows

et al. 2021

Cancers

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Background: Magnetic Particle Imaging (MPI) is an emerging imaging modality for quantitative direct imaging of superparamagnetic iron oxide nanoparticles (SPION or SPIO). With different physics from MRI, MPI benefits from ideal image contrast with zero background tissue signal. This enables clear visualization of cancer with image characteristics similar to PET or SPECT, but using radiation-free magnetic nanoparticles instead, with infinite-duration reporter persistence in vivo. MPI for cancer imaging: demonstrated months of quantitative imaging of the cancer-related immune response with in situ SPION-labelling of immune cells (e.g., neutrophils, CAR T-cells). Because MPI suffers absolutely no susceptibility artifacts in the lung, immuno-MPI could soon provide completely noninvasive early-stage diagnosis and treatment monitoring of lung cancers. MPI for magnetic steering: MPI gradients are ~150 × stronger than MRI, enabling remote magnetic steering of magneto-aerosol, nanoparticles, and catheter tips, enhancing therapeutic delivery by magnetic means. MPI for precision therapy: gradients enable focusing of magnetic hyperthermia and magnetic-actuated drug release with up to 2 mm precision. The extent of drug release from the magnetic nanocarrier can be quantitatively monitored by MPI of SPION’s MPS spectral changes within the nanocarrier. Conclusion: MPI is a promising new magnetic modality spanning cancer imaging to guided-therapy.

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Section: Magnetic Methods For Cancer Therapy In Context Of Magnetic Particle Imagingmentioning

confidence: 99%

Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Tay

Chandrasekharan

Fellows

et al. 2021

Cancers

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“…MPI present several advantages: ideal penetration and signal-noise ratio, no view limitations, highly sensitive, linear and quantitative signal, high contrast, zero ionizing radiation, and safer and persistent. All this makes this technique an excellent non-invasive 3D tomographic imaging method to be combined with MHT for a real-time therapy image guided [ 15 , 87 ].…”

Section: Physical Concepts Of Magnetic Hyperthermia (Mh)mentioning

confidence: 99%

“…Nevertheless, it would be desirable to have a single equipment where in vivo location and MHT could be performed simultaneously. However, limitations intrinsic to the technique (as different magnetic field requirements between MRI and MHT) do not allow a real-time guidance [ 15 ].…”

Section: Introduction: From Cancer To Magnetic Hyperthermia Therapy Via Nanomedicinementioning

confidence: 99%

Understanding MNPs Behaviour in Response to AMF in Biological Milieus and the Effects at the Cellular Level: Implications for a Rational Design That Drives Magnetic Hyperthermia Therapy toward Clinical Implementation

Egea-Benavente

Ovejero

Morales

et al. 2021

Cancers

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Hyperthermia has emerged as a promising alternative to conventional cancer therapies and in fact, traditional hyperthermia is now commonly used in combination with chemotherapy or surgery during cancer treatment. Nevertheless, non-specific application of hyperthermia generates various undesirable side-effects, such that nano-magnetic hyperthermia has arisen a possible solution to this problem. This technique to induce hyperthermia is based on the intrinsic capacity of magnetic nanoparticles to accumulate in a given target area and to respond to alternating magnetic fields (AMFs) by releasing heat, based on different principles of physics. Unfortunately, the clinical implementation of nano-magnetic hyperthermia has not been fluid and few clinical trials have been carried out. In this review, we want to demonstrate the need for more systematic and basic research in this area, as many of the sub-cellular and molecular mechanisms associated with this approach remain unclear. As such, we shall consider here the biological effects that occur and why this theoretically well-designed nano-system fails in physiological conditions. Moreover, we will offer some guidelines that may help establish successful strategies through the rational design of magnetic nanoparticles for magnetic hyperthermia.

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“…143,320 Interest as a therapeutic treatment can be attributed to multiple key advantages, including: no fundamental depth limitation, synergy with many other therapies (e.g., chemotherapies), and internalisation of the 'fluidic' heat source. 321 The most frequently used MFH application paradigms are whole-body MFH (Fig. 21a), where homogeneous AMF-generating alternating current (AC) coils scan the whole-body for sites of accumulation, and local MFH (Fig.…”

Section: Magnetic Fluid Hyperthermiamentioning

confidence: 99%

Magnetic particle imaging: tracer development and the biomedical applications of a radiation-free, sensitive, and quantitative imaging modality

2022

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Combining magnetic particle imaging and magnetic fluid hyperthermia for localized and image-guided treatment

Cited by 49 publications

References 105 publications

Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Magnetic Particle Imaging: An Emerging Modality with Prospects in Diagnosis, Targeting and Therapy of Cancer

Understanding MNPs Behaviour in Response to AMF in Biological Milieus and the Effects at the Cellular Level: Implications for a Rational Design That Drives Magnetic Hyperthermia Therapy toward Clinical Implementation

Magnetic particle imaging: tracer development and the biomedical applications of a radiation-free, sensitive, and quantitative imaging modality

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