Spatial cytokine distribution following traumatic injury

Currie, Holly N.; Loos, Matthew S.; Vrana, Julie A.; Dragan, Kristen; Boyd, Jonathan

doi:10.1016/j.cyto.2014.01.001

Cited by 27 publications

(48 citation statements)

References 42 publications

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“…Measurement of cytokines has also focused the interest of researchers in traumatic injury on other organs. 7 Of particular interest to our discussion on injury to the central nervous system is the recent study by LaPar et al 13 on cytokine profiles in patients with no traumatic and traumatic head injuries. This study involved 1,022 patients over 5 years, making it one of the largest retrospective studies on cytokine profiles.…”

Section: Discussionmentioning

confidence: 99%

“…16 There also appears to be a correlation between cytokine levels and distance from the lesion. 7 Understanding this spatial and temporal relationship of cytokine levels could be beneficial in targeting cytokines in the process of tissue repair and regeneration 17 and would be of interest in investigating SCI. Because of the obvious problems in extraction of tissue samples from the spinal cord, we were only able to use venous blood as our medium.…”

Section: Discussionmentioning

confidence: 99%

“…Research has shown that temporal cytokine responses can be used as objective predictors of wound healing and aid surgeons contemplating procedure selection and timing. 7,8 This raises the question of whether cytokine levels would yield similar revelations and perhaps improve the treatment of SCI. Temporal cytokine levels after SCI have not been adequately assessed; to fill this gap, we recently measured sCD95L in nine SCI patients.…”

Section: Introductionmentioning

confidence: 99%

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A pilot study on temporal changes in IL-1β and TNF-α serum levels after spinal cord injury: the serum level of TNF-α in acute SCI patients as a possible marker for neurological remission

Biglari¹,

Swing

Child

et al. 2015

Spinal Cord

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Study design: Serum levels of interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) were measured over a 12-week period in 23 patients with spinal cord injury (SCI) with and without neurological improvement. Objectives: To determine the course of IL-1β and TNF-α in patients with SCI and observe a possible relationship between improvements in neurological functioning and cytokine levels. Setting: All patients were treated at the BG Trauma Centre, Ludwigshafen, Germany. All lab work was done at the University Hospital, Heidelberg. Methods: Spinal cord injury was classified according to the American Spinal Injury Association (ASIA) impairment scale (AIS) in 23 patients. TNF-α and IL-1β levels were measured upon arrival at the hospital, after 4 h, 9 h and 12 h, on days 1 and 3 and at the end of weeks 1, 2, 4, 8 and 12. Results: Temporal changes in TNF-α and IL-1β in SCI patients were seen. Patients with AIS improvement (Group 1) had significantly lower TNF-α levels at 9 h compared with patients without AIS improvement (Group 2; Po0.01). The course of IL-1β fluctuated greatly between 4 h and week 1 in the groups; however, between 2 and 12 weeks post trauma, there was an overall decline in both groups. Conclusion: Measuring serum levels of TNF-α and IL-1β over time could be useful in tracking the course of SCI. Our data show differences in measured cytokines over a 12-week period for SCI patients with and without neurological improvement.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A pilot study on temporal changes in IL-1β and TNF-α serum levels after spinal cord injury: the serum level of TNF-α in acute SCI patients as a possible marker for neurological remission

Biglari¹,

Swing

Child

et al. 2015

Spinal Cord

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“…54 Additionally, the IL-2 level in the muscle was higher at the fracture site than 1 cm away from it immediately following the fracture, where it could be playing a role in the initiation of healing. To further clarify the timing and location of IL-2 signaling, this group went on to perform a further study, which included not only IL-2 levels but also phosphorylation states of some downstream signaling pathways for the IL-2Rs.…”

Section: Systemic Effects Of Il-2 On Wound Healingmentioning

confidence: 99%

“…54,55 This group examined IL-2 signaling within the muscle and blood vessels at the fracture site, 1 cm away from the fracture site, and in the opposite, unbroken limb at 0, 6, 24, and 168 h after the fracture. The data comparing IL-2 levels and the phosphorylation states of downstream signaling molecules are consistent with the possibility that systemic IL-2 contributes to wound healing.…”

Section: Systemic Effects Of Il-2 On Wound Healingmentioning

confidence: 99%

The contribution of interleukin-2 to effective wound healing

Doersch

DelloStritto

Newell‐Rogers

2016

Exp Biol Med (Maywood)

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Ineffective skin wound healing is a significant source of morbidity and mortality. Roughly 6.5 million Americans experience chronically open wounds and the cost of treating these wounds numbers in the billions of dollars annually. In contrast, robust wound healing can lead to the development of either hypertrophic scarring or keloidosis, both of which can cause discomfort and can be cosmetically undesirable. Appropriate wound healing requires the interplay of a variety of factors, including the skin, the local microenvironment, the immune system, and the external environment. When these interactions are perturbed, wounds can be a nidus for infection, which can cause them to remain open an extended period of time, or can scar excessively. Interleukin-2, a cytokine that directs T-cell expansion and phenotypic development, appears to play an important role in wound healing. The beststudied role for Interleukin-2 is in influencing T-cell development. However, other cell types, including fibroblasts, the skin cells responsible for closing wounds, express the Interleukin-2 receptor, and therefore may respond to Interleukin-2. Studies have shown that treatment with Interleukin-2 can improve the strength of healed skin, which implicates Interleukin-2 in the wound healing process. Furthermore, diseases that involve impaired wound healing, such as diabetes and systemic lupus erythematosus, have been linked to deficiencies in Interleukin-2 or defects Interleukin-2-receptor signaling. The focus of this review is to summarize the current understanding of the role of Interleukin-2 in wound healing, to highlight diseases in which Interleukin-2 and its receptor may contribute to impaired wound healing, and to assess Interleukin-2-modulating approaches as potential therapies to improve wound healing.

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Immunomodulation Using BMP‐7 and IL‐10 to Enhance the Mineralization Capacity of Bone Progenitor Cells in a Fracture Hematoma‐Like Environment

Wiesli,

Huber,

Weisse

et al. 2024

Adv Healthcare Materials

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Following biomaterial implantation, a failure to resolve inflammation during the formation of a fracture hematoma can significantly limit the biomaterial's ability to facilitate bone regeneration. This study aimed to combine the immunomodulatory and osteogenic effects of BMP‐7 and IL‐10 with the regenerative capacity of collagen‐hydroxyapatite (CHA) scaffolds to enhance in vitro mineralization in a hematoma‐like environment. Incubation of CHA scaffolds with human whole blood led to rapid adsorption of fibrinogen, significant stiffening of the scaffold, and the formation of a hematoma‐like environment characterized by a limited capacity to support the infiltration of human bone progenitor cells, a significant upregulation of inflammatory cytokines and acute phase proteins, and significantly reduced osteoconductivity. CHA scaffolds functionalized with BMP‐7 and IL‐10 significantly downregulated the production of key inflammatory cytokines, including IL‐6, IL‐8, and leptin, creating a more permissive environment for mineralization, ultimately enhancing the biomaterial's osteoconductivity. In conclusion, targeting the onset of inflammation in the early phase of bone healing using BMP‐7 and IL‐10 functionalized CHA scaffolds is a promising approach to effectively downregulate inflammatory processes while fostering a more permissive environment for bone regeneration.This article is protected by copyright. All rights reserved

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Spatial cytokine distribution following traumatic injury

Cited by 27 publications

References 42 publications

A pilot study on temporal changes in IL-1β and TNF-α serum levels after spinal cord injury: the serum level of TNF-α in acute SCI patients as a possible marker for neurological remission

A pilot study on temporal changes in IL-1β and TNF-α serum levels after spinal cord injury: the serum level of TNF-α in acute SCI patients as a possible marker for neurological remission

The contribution of interleukin-2 to effective wound healing

Immunomodulation Using BMP‐7 and IL‐10 to Enhance the Mineralization Capacity of Bone Progenitor Cells in a Fracture Hematoma‐Like Environment

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