Spatial Correlation between Hyperpigmentary Changes on Color Fundus Photography and Hyperreflective Foci on SDOCT in Intermediate AMD

METHODS. In this cross-sectional study, retinal sensitivities within the central 248 retina were obtained twice using a dark-adapted chromatic perimeter, both with 505-and 625-nm stimuli. Tests were performed after 30 minutes of dark-adaptation either with or without a preceding photobleach. Multimodal imaging was performed to grade AMD and SDD status, and other retinal changes considered being risk factors for progression to late AMD. The sensitivity difference between both stimuli was used to assess rod function. The average point wise sensitivity difference (PWSD) was compared among the study groups.RESULTS. Twenty-nine control subjects and 20 iAMD without SDD and 17 iAMD with SDD cases were recruited. The average PWSD of the SDD group was significantly reduced (more with photobleach) compared with that of the control (P < 0.001) and no-SDD groups (P < 0.001), but only within the central 88. The average PWSD of the non-SDD group was also reduced compared with the control group but only for measurements with photobleach (P ¼ 0.020). There was no difference in average PWSD between the presence and absence of hyperreflective foci and/or nascent geographic atrophy in iAMD eyes without SDD (P ¼ 0.60) or with SDD (P ¼ 0.12).CONCLUSIONS. iAMD eyes with SDD are associated with worse static rod function compared with eyes without SDD. The greatest abnormality in rods is observed within the central 88 and when tested with a preceding photobleach.

Section: Clinical Gradingmentioning

confidence: 99%

mentioning

confidence: 99%

Subretinal Drusenoid Deposits and the Loss of Rod Function in Intermediate Age-Related Macular Degeneration

Tan

Guymer

Luu

2018

“…Instead, this study considered HF located within the EZþOS to be (y ¼ 1). The original metric also considered the RNFL, RGCþIPL, and INL combined as (y ¼ 5), instead of the INL only in this study, because no HF were observed in the other layers in our previous study 28 and we sought to avoid the improper automatic identification of blood vessels as HF; all other designations for the calculation agreed. 6 In cases in which layers are missing due to pathologic changes, the location of a HF is defined as first visible layer above the HF.…”

Section: Imaging and Image Analysismentioning

confidence: 99%

Longitudinal Associations Between Microstructural Changes and Microperimetry in the Early Stages of Age-Related Macular Degeneration

Cunefare

Chiu

et al. 2016

Self Cite

PURPOSE. To determine whether longitudinal changes in mesopic visual function on microperimetry occurred independent of its associations with microstructural parameters on spectral-domain optical coherence tomography (SD-OCT) in the early stages of AMD.METHODS. Forty-one AMD eyes underwent microperimetry testing and SD-OCT scans over a 12-month period at 6-month intervals. Microstructural parameters analyzed include the retinal pigment epithelium-drusen complex (RPEDC) layer thickness, number of hyperreflective foci (HF) and their inner retinal migration (represented by a weighted axial distribution score; AxD), and the number of atrophic areas.RESULTS. Microperimetric sensitivity was 0.29 dB (95% confidence interval [CI] ¼ À0.38 to À0.20 dB, P < 0.001) and 0.13 dB (95% CI ¼ À0.22 to À0.03 dB, P ¼ 0.008) lower in each sector for every 10-lm higher RPEDC layer thickness and 1-HF present, but was not associated with the AxD score or the number of atrophic areas present (P 0.464). However, each 10-lm greater RPEDC layer thickness and 1-HF present was not independently associated with a further decline in sensitivity (À0.08 dB/year, 95% CI ¼ À0.24 to 0.07 dB/year, P ¼ 0.288 and 0.09 dB/year, 95% CI ¼ À0.06 to 0.24 dB/year, P ¼ 0.242, respectively) over time when accounting for the association between RPEDC layer thickness and number of HF with microperimetric sensitivity. CONCLUSIONS.Longitudinal changes in mesopic visual function measured on microperimetry paralleled changes in the microstructural changes over a 12-month time frame, without any changes occurring independent of the associations between structure and function alone.

“…5 It has been demonstrated that there is a highly specific spatial correlation of HRF with the apex of drusen 6 and/or subretinal drusenoid deposits (SDD) 4 and that HRF overlying drusen are associated with an increased risk of atrophy at that location. 7 The AREDS2 Ancillary SD-OCT Study reported that GA lesions detected at 2 years were significantly correlated with the presence of HRF and with a greater number of HRF at baseline.…”

mentioning

confidence: 99%

Quantity of Intraretinal Hyperreflective Foci in Patients With Intermediate Age-Related Macular Degeneration Correlates With 1-Year Progression

Nassisi

Fan

Shi

et al. 2018

METHODS. Volume optical coherence tomography (OCT) scans from 114 eyes of 114 patients were retrospectively reviewed. HRF were assessed both qualitatively and quantitatively. Five sequential en face slabs from midretina were thresholded to isolate the HRF. These five slabs were recombined, and HRF area was measured in the whole 6 3 6-mm image (HRF TOT ) and within the central 3-mm (HRF 3mm ) and 5-mm (HRF 5mm ) regions. These measurements were correlated with the development of late AMD (defined as choroidal neovascularization [CNV] and/or complete RPE and photoreceptor atrophy [cRORA]) after 1 year of follow-up.RESULTS. HRF area in all three regions showed significant correlations with progression to late AMD: R ¼ 0.610 for HRF 3mm , R ¼ 0.622 for HRF 5mm , and R ¼ 0.614 for HRF TOT (all P < 0.001). Correlations remained significant with progression to cRORA alone, though not for progression to CNV alone. While qualitative assessment of HRF (i.e., presence of HRF: yes or no) also showed a significant correlation with progression to late AMD (R ¼ 0.454, P < 0.001) and atrophy alone (R ¼ 0.445, P < 0.001), they were weaker than by HRF quantification.CONCLUSIONS. The area of HRF from en face OCT in eyes with intermediate AMD correlates with the 1-year risk of progression to late AMD, and in particular with the development of atrophy.